Current Indian Science - Current Issue

Cancer is a complex disorder characterized by the unregulated proliferation of cells that have the potential to invade other regions of the body. It stems from genetic alterations in various cell types, resulting in tumor formation. These growths are classified as benign (noncancerous) or malignant (cancerous). Unlike benign tumors, which typically remain localized, malignant tumors can spread, infiltrate nearby tissues, a Read More

Background To overcome the drugs’ low bioavailability and/ or solubility, the development of novel oral delivery approaches using lipid-based formulations has been of growing interest. Curcumin being a Class IV drug, has poor solubility and poor permeability. One of the biggest obstacles to its use in therapeutic treatment is this. Objective In order to increase drug bioavailability, this research aimed to create Solid Dispersi Read More

Background The presence of synthetic dyes like Congo Red in wastewater poses serious and persistent environmental health hazards as a result of their toxicity and stability. Therefore, developing an efficient and reusable adsorbents for the elimination of dye is quite important in order to address water pollution challenges. Objective The study aims to classify the efficacy of sodium borohydride-reduced Bent/Fe NPs and cr Read More

Floating drug delivery systems are significant for gastric retention characteristics and improving the absorption and bioavailability of drugs. Several polymers have been used in such systems as drug carriers. Biopolymers, including alginate, chitosan, guar gum, and gelatin obtained from plant or animal sources have also been applied in such systems. Such biopolymers are biocompatible and biodegradable and provide suitable ch Read More

Heavy metal contamination in soil and water poses a severe global environmental challenge, particularly in rapidly industrialized regions. While conventional remediation methods exist, their widespread implementation is hindered by high costs, time-intensive processes, and complex technical requirements. This review aimed to explore an innovative approach combining phytoremediation with green-synthesized selen Read More

Dermatophytes typically cause onychomycosis, which accounts for 50% of all nail diseases. Although formerly thought to be a cosmetic issue, it has recently gained attention because of its chronic nature and challenging treatment with relapses. Due to the lengthy treatment period and high expense associated with treating onychomycosis, numerous attempts have been made to overcome the hard nail barrier. Oral and topic Read More

Introduction Asparaginase, an enzyme that changes L-asparagine into L-aspartic acid, has attracted a lot of interest recently due to its potential to prevent the development of cancer. Methods In the present study, the endophytic fungi isolated from wild mushrooms were tested for their ability to produce extracellular L-asparaginase. Results The isolated organism was identified as Rhizomucor variabilis strain CBS 103.93 by mor Read More

Genus Citrus, with a handful of the most extensively grown fruit crops in the world, is home to an unknown number of plant species. Since they are very perishable, many neglected citrus varietals are yet unexplored. Citrus pseudolimon Tan., sometimes known as Hill Lemon, is a lesser-known citrus species with relatively little research available on it when compared to other prominent citrus cultivars. To the best of our knowled Read More

Traumatic Brain Injury (TBI) is a complex type of brain damage caused by external factors. Depression is one of the major comorbidities that follow, making things more difficult for patients and caregivers. Post-traumatic depression is a serious condition that can increase rates of death and morbidity, especially as it gets worse. Though constant discussion exists about the best ways to treat the condition, a conclusive answer Read More

Atopic dermatitis (AD), a disorder that is on the rise, affects about 20% of people globally, including children. It is believed that immunological inadequacies, pathogenic microorganisms, the environment, and anomalies in the function of the epidermal barrier interact intricately with the pathophysiology of AD. Studies on the impact of oxidative stress on many skin conditions have been carried out, but there aren’t many Read More

Background Natural essential oil comprises a galaxy of low-molecular-weight (usually less than 500 daltons) and volatile phytoconstituents that exhibit a handful of biological and pharmaceutical properties; they exhibit several applications chiefly in agriculture, cosmetic, perfumeries, and food industries. Methods The extraction of essential oil from fresh flowers of C. sophera was performed by hydrodistillation, and the det Read More

Cognition is the interdisciplinary scientific study of the brain and its processes, which include the intelligence and behaviour of living beings. Humans are generally equipped with a capacity for cognitive function at birth, but some conditions, such as infection and oxidative stress, lead to impaired cognition. Herbal drugs/phytochemicals are utilized in order to get better cognitive functions and alleviate symptoms associated with im Read More

Mitapivat (AG-348) is a novel, first-in-class oral small-molecule allosteric activator of the pyruvate kinase enzyme. Mitapivat has been shown to significantly upregulate both wild-type and numerous mutant forms of erythrocyte pyruvate kinase (PKR), increasing adenosine triphosphate (ATP) production and reducing levels of 2,3-diphosphoglycerate. Given this mechanism, mitapivat has been evaluated in clinical trials in a wide Read More

Introduction Poor solubility is a common challenge in pharmaceuticals, hindering oral bioavailability. High throughput screening has led to an increase in poorly soluble drug candidates. Enhancing solubility and dissolution rates is crucial for drug development. Various methods, including solid dispersion, aim to improve solubility. A solid dispersion formulation process involves dispersing one or more active chemicals in a s Read More