Current Indian Science - Online First

The excessive exploitation of antibiotics for the treatment of bacterial illnesses has resulted in the emergence of several strains that are resistant to different drugs. Due to the widespread occurrence of antibiotic resistance and the emergence of bacterial strains that are resistant to various drugs, significant efforts are being made to identify appropriate alternative medicines to combat harmful microorganisms. Given the observed link between biofilm formation and antibiotic resistance, recent efforts have been directed towards a promising strategy that aims to control and prevent biofilm formation. This strategy involves targeting and inhibiting the quorum sensing system, which has been extensively shown to play a central role in biofilm formation. The conventional approach to controlling infectious disorders involves the use of substances that are designed to either kill or inhibit the growth of bacteria. Bacterial resistance to antibiotics poses a significant challenge to public health. This therapeutic target has been extensively explored globally. However, the scientific data on it are not up-to-date, and only recent studies have begun to explore its potential as a target for combating infectious diseases. An important issue with this strategy is the commonly observed emergence of resistance to antimicrobial agents. This paper aimed to present a comprehensive overview of the quorum sensing system in bacteria, focusing on its role in biofilm formation and the development of antibiotic resistance. Additionally, it provides an update on the significance of targeting this system with natural substances for therapeutic purposes.