Letters in Organic Chemistry - Online First

The Bacillus cereus group includes eight well-characterized and established species, whose classification and identification have been arduous and intense tasks. The similarity between Bacillus cereus group species and the discovery of new strains have complicated their classification and identification. The chemical profile can be complementary, along with molecular methodologies, to classify Bacillus species. With this iss Read More

This study aimed to carry out highly efficient and simple cross-coupling reactions of arylboronic acid with methyl dithiocarbamates for the synthesis of thioamide derivatives using Ni(acac)2(5 mol%)/TFP(5 mol%) as a catalyst. Under the optimized reaction conditions, the coupling reaction between arylboronic acid with methyl dithiocarbamates was carried out smoothly, and thioamides were obtained with 27-85% isolated y Read More

Novel simple approach was elaborated for the preparation of fentanyl and sufentanil starting from commercially available, cheap 1-methyl-4-piperidone. Compared to existing syntheses new route is shorter, easily scalable, and does not require the use of expensive palladium catalysts, high-pressure equipment, and chromatographic separations. Moreover, it allows for to avoidance of working with the unstable norsufent Read More

Understanding the rotational barriers (RBs) and bond dissociation enthalpies (BDEt) of substituted aromatic compounds is crucial for predicting their chemical reactivity and stability. The RBs for 26 varying para-substituted anilines, benzaldehydes, and toluenes around the respective phenyl-NH2, -CHO, and -CH3 bonds, as well as around the corresponding radical phenyl-NH, -CO, and -CH2 bonds, were computed, based on th Read More

Herein, we disclose an eco-friendly route for the synthesis of 2,4,5-triaryl-1H-imidazole derivatives. One-pot, three-component synthesis involving benzil, substituted aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of trihexyltetradecyl-phosphonium bis(2,4,4-trimethylpentyl)phosphinate (PBIL) ionic liquid in ethanol at room temperature yields corresponding 2,4,5-triaryl-1H-imidazole derivative Read More

A novel arylalkanone, 1-(2’,6’-dihydroxyphenyl)-4-hydroxy-9-(3”,4”-dihydroxyphenyl)-nonan-1-one (1), along with five known arylalkanones, malbaricone A (2), malbaricone B (3), malbaricone C (4), malbaricone D (5) and 1-(2’, 6’-dihydroxyphenyl) tetradecan-1-one (6), and a dimeric acylphenol, giganteone A (7), which is newly reported for this plant, were isolated and characterized from seed mace of Myristica ceylanica.

The present article describes a theoretical study of the reaction mechanism involved in the conversion of cholest-4-en-3-one to 5α-cholest-3-eno-[3,4-b] quinoxaline. In this study, the reaction proceeded via condensation, cyclization, and oxidation. The reaction pathway was characterized using Frontier Molecular Orbital analysis and a comparison of relative energies, which were computed using the theoretical approach of Read More

A new method has been developed for the synthesis of pyrano[3,2-c] and pyrano[2,3-a]carbazole derivatives via a three-component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, aromatic aldehydes, and arylenaminones. This transformation presumably occurs via Knoevenagel condensation, Michael addition, o-cyclization, elimination, and isomerization sequence of reactions. Noteworthy features of this protocol Read More

Leea indica (Burm.f.) Merr. is a Vietnamese traditional medicinal plant used for the treatment of many different diseases. However, there has been no investigation of chemical constituents and biological activities of it. Isolated compounds from L. indica consist of two phenolics, gallic acid (1) and 3,4,3′-tri-O-methylellagic acid (2), two flavonoids, quercitrin (3) and myricitrin (4), three triterpenoids, ursolic acid (5), maslinic acid (6), a Read More

In this study, the synthesis of (2S,6R,10R) and (2R,6R,10R) diastereomers of pristanic acid is described. The key step in this synthesis is the dehomologation of (3RS,7R,11R)-dihydrophytol to one-carbon shorter (2RS,6R,10R)-pristanic acid using o-iodoxybenzoic acid. The diastereomeric mixture of pristanic acid is easily separated by silica gel column chromatography after conversion to the corresponding amides, which c Read More