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2000
Volume 22, Issue 10
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

(Burm.f.) Merr. is a Vietnamese traditional medicinal plant used for the treatment of many different diseases. However, there has been no investigation of chemical constituents and biological activities of it. Isolated compounds from consist of two phenolics, gallic acid () and 3,4,3′-tri--methylellagic acid (), two flavonoids, quercitrin () and myricitrin (), three triterpenoids, ursolic acid (), maslinic acid (), and hederagenin (), one alkaloid, tetrandrine () and three steroids, -sitosterol (), stigmasterol (), and daucosterol (). Among them, compounds , , , , and were isolated from for the first time. Moreover, the ethyl acetate extract of leaves (LILE), ethyl acetate extract of stem barks (LISBE), methanol extract of leaves (LILM) from , and the mixture of -sitosterol () and stigmasterol () significantly inhibited nitric oxide (NO) production, with IC values of 10.01 ± 0.35, 15.51 ± 0.61, 11.38 ± 1.01, and 59.36±10.23 µg/mL, respectively. The percentage of inhibition of edema reached 26.53% after treatment with daucosterol () at a dose of 100 mg/kg b.wt. The LILE was also found to exhibit the greatest cytotoxic effect against all four cell lines tested with IC values ranging from 7.22 to 10.65 µg/mL. These results confirmed that the extracts of leaf and stem bark, as well as compounds / and exhibit very potential anti-inflammatory and cytotoxic effects.

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Chemical Constituents and Biological Activities of Vietnamese Leea indica (Burm. f.) Merr.
Lett. Org. Chem. 22, 764 (2025); https://doi.org/10.2174/0115701786361790250318171101
/content/journals/loc/10.2174/0115701786361790250318171101
/content/journals/loc/10.2174/0115701786361790250318171101
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  • Article Type:     Research Article
Keyword(s): anti-inflammation; chemical constituents; cytotoxicity; isolation; Leea indica; secondary metabolites

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