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2000
Volume 22, Issue 12
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

By employing a catalytic proportion of Co-AlO-SOH in a three-component Biginelli-type condensation, combining various aromatic aldehydes, 1,3-cyclohexadione, and urea, practical one-pot synthesis of hexahydroquinazolinone was accomplished. This method yielded hexahydroquinazolinones in good yields, which were further enhanced under reflux conditions. This approach offers several significant advantages, including high efficiency, straightforward reaction conditions, simple workup, reusable catalysts, superior yields, and shorter reaction times. The structure of the produced heterogeneous catalyst Co-AlO-SOH was analyzed using Brunauer-Emmett-Teller (BET) analysis, X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM).

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2025-07-02
2025-12-14

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One-pot Synthesis of Hexahydroquinazolinone using Co-Al2O3-SO3H as an Efficient Catalyst
Lett. Org. Chem. 22, 905 (2025); https://doi.org/10.2174/0115701786380443250530044225
/content/journals/loc/10.2174/0115701786380443250530044225
/content/journals/loc/10.2174/0115701786380443250530044225
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  • Article Type:     Letter
Keyword(s): aromatic aldehydes; Biginelli type reaction; condensation; heterogeneous catalyst; hexahydroquinazolinone; one-pot synthesis

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