Letters in Organic Chemistry - Current Issue
Volume 22, Issue 7, 2025
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DABCO-Based Ionic Liquids: A Non-Conventional Catalyst for the Synthesis of N-Substituted 2-Nitrophenylamines
Authors: Ambika and Pradeep Pratap SinghIsoalloxazines are the essential cofactors of flavoproteins, which are responsible for the different redox reactions in various biological processes. They can be efficiently synthesized using N-substituted 2-nitrophenylamines as a precursor. In the present communication, we report a simple and efficient method for the synthesis of N-substituted 2-nitrophenylamines in DABCO-based ionic liquids. The method offers the use of DAB Read More
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- Chemistry, Organic Chemistry
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Synthesis, Reactions and Biological Activities of Pyrimido[4,5-c] Isoquinolines (Part III)
Isoquinoline and pyrimidine are valuable heterocyclic compounds that play a crucial role in the development of new drug molecules. The combination of isoquinoline and pyrimidine moieties in hybrid structures has provided exciting possibilities for various applications, leading to the discovery of pyrimidoisoquinoline (PyIsoQ) compounds, such as pyrimido[4,5-c]isoquinolines and pyrimido[5,4-c]isoquinolines, w Read More
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Computational Screening of Phytochemicals in Eupatorium adenophorum Extracts for Modulating Blood Coagulation: A Pharmacoinformatics Study
Authors: Sushmita Dwivedi and Mamta BaunthiyalWound healing is a natural phenomenon that allows tissue to repair itself after any injury. To minimize any complexity associated with wounds, they are managed with medications. Nowadays, there is growing interest in alternative sources of medication. Scientists are contemplating finding more potential in plant compounds that are promising drug targets in blood coagulation, inflammation, and wound healing research. Although Read More
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An Improved and Practical Approach to the Synthesis of Terbinafine as an Anti-Fungal Agent
Authors: V. Satteyyanaidu, P.N. Reddy, S. Gajula, U. Poojitha, G. Nalla and B.V.S. ReddyAn improved strategy for the synthesis of terbinafine has been developed through the cross-coupling of (E)-aminovinyl chloride with tert-butyl acetylene using 1 mol% of 5% Pd/C as a recyclable heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.
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Synthesis of Epilepsy Drug Brivaracetam through Solvent-free Lactamization
Authors: Saurabh Kumar Singh, Partha Ghosh and Rajendra PrasadBrivaracetam is a relatively new racetam drug for the treatment of epilepsy, synthesis of which with proper stereocontrol remains challenging. Herein we describe a solvent-free lactamization method for the development of two efficient synthetic routes to brivaracetam. The key method is a one-step condensation of amines with chiral α-carboxyethyl-β-propyl butyrolactone under neat conditions that proceed through tandem Read More
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A Novel Enantioselective Synthesis of Cryptophycins Unit A from Rocher’s Ester
Authors: Abdelmoumin Mezrai, Lahouari Mrah and Zoulikha KhiatiA novel synthesis of cryptophycin unit A in its enantiomerically pure form was achieved. In five steps, an enantiomeric mixture of unit A was initially prepared from trans-cinnamaldehyde. Subsequently, in its enantiomerically pure forms, unit A was prepared from Rocher’s ester in six steps, involving an essential aldehyde (2R,3E)-2-methyl-4-phenylbut-3-enal. The final step of this process involved two different approaches: a Read More
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Synthesis and Anticancer Activity Evaluation of N-(3,4,5-Trimethoxycinnamoyl)anthranilic Acid Derivatives
There is an urgent need to search for more efficient, better-tolerated anticancer drugs. Tranilast, a synthetic analog of tryptophan metabolite, has been shown to inhibit the growth of various cancer cells. In our previous study, the tranilast analog TRA01 [N-(3,4,5-trimethoxycinnamoyl) anthranilic acid] was identified as a promising agent against the proliferation of MCF-7 and HepG2 cell lines along with good binding affin Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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