Access to β-Hydroxy Ketones Using Reconstructed Hydrotalcite (Mg-Al LDH) as a Heterogeneous Catalyst

In this study, we aimed to describe a reconstructed hydrotalcite (Mg-Al LDH) catalyzed synthesis of β-hydroxy ketones from aldol condensation between acetone and aromatic aldehydes under room temperature. The performance of the catalyst, including catalytic activity, reaction selectivity, and reusability, as well as the general applicability of the catalytic method, was thoroughly evaluated. The reconstructed magnesium-aluminum hydrotalcite catalyst described in this study featured easy preparation, low cost, and high safety and efficiency, representing an excellent approach for catalyzing aldol condensation reactions under heterogeneous conditions.