Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Current Issue

Introduction Haemophilus influenzae, a gram-negative, facultative anaerobic coccobacillus, is a member of the Pasteurellaceae family. It causes a variety of invasive and non-invasive bacterial infections known as H. influenzae infections. The increasing prevalence of antibiotic resistance highlights the need to identify novel therapeutic targets for treating H. influenzae infections. The emerging trends in the field of Pharma Read More

AimsTo investigate the pharmacological implications of the ligand cis-4-Benzyl-2,6-diphenyltetrahydropyran, focusing on its pathways, potential disease associations, and therapeutic applications in Type 2 Diabetes Mellitus (T2DM).Background/IntroductionCis-4-Benzyl-2,6-diphenyltetrahydropyran has been previously identified for its heightened binding affinity to T2DM targets. Understanding its diverse pat Read More

Background/IntroductionThe research highlights the effect of phytochemical compounds on the correlation of cellular pathways of cytokines and antioxidant enzymes at the molecular levels.ObjectiveThis work examines the effects of phytochemical substances on the expression of (IL1β and IL6, IL10) genes present in different amounts in garlic, grape seed, and pomegranate extracts in various amounts. Within the same fram Read More

Background/IntroductionLung cancer (LC) is a lethal malignancy with a late diagnosis and poor prognosis. During the last decade, the identification of oncogenic driver alterations has noticeably changed the therapeutic landscape and contributed to the emergence of the “oncogene addiction” concept and precision medicine in oncology. Among these alterations, the spotlight has turned to driver mutations in the KRAS and BRAF Read More

IntroductionNeurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of benign tumors due to mutations in the NF1 gene, which encodes the tumor suppressor neurofibromin. This study aimed to identify novel inhibitors of neurofibromin through drug repurposing of clinical trial compounds from the Zinc15 database.MethodsUtilizing advanced in silico techniques, we conducted molecular docking vi Read More

Type 2 diabetes mellitus is one of the leading causes of morbidity and mortality in the world. The two main components of the mechanism underlying T2DM are insulin resistance and impaired insulin secretion. The current algorithmic approach to the treatment of the disease does not take the individual genetic makeup of patients into consideration. However, multiple gene variants affect the efficacy and metabolism of Read More

Background/IntroductionThe Calcitonin receptor (CALCR) gene encodes a protein essential for bone metabolism, playing a key role in inhibiting bone resorption and promoting renal calcium excretion. Polymorphisms in CALCR have been associated with differences in bone mineral density, osteoporosis, and an increased risk of calcium stone urolithiasis.AimThis study aimed to investigate the non-synonymous SNPs of human Read More

Background/IntroductionDental caries is a biofilm-mediated disease driven by dietary sugars that reduce pH and promote cariogenic microorganisms. Caries result from a complex interplay of behaviour, environmental, genetic, and physiological factors, with the immune response and bacterial activity contributing to enamel demineralization and cavity formation. Genetic factors, such as SNPs, also influence caries Read More

AimsTo examine whether novel lead hypertension molecules can be used in the personalized treatment of hypertension.Background/IntroductionHypertension is a modifiable condition that affects over 1 billion adults worldwide. Maintaining a healthy blood pressure is vital for overall health, especially given that hypertension is a primary risk factor for developing cardiovascular conditions. H Read More

Background/IntroductionDental caries result from the demineralization of enamel or dentin caused by acids produced by cariogenic oral bacteria. The Glutathione S-transferase P1 (GSTP1) is a prominent member of the GST family, and it exhibits several genetic polymorphisms, with rs1695 being the most common variant.AimOur study is to investigate the relationship between GSTP1 rs1695 polymorphism and the susceptibi Read More

Background/IntroductionCancer is one of the serious health issues and the leading cause of mortality worldwide. Several studies have demonstrated that the overexpression of growth factors and receptors, the triggering of oncogenes, and the deactivation of tumor suppressor genes are the main causes of aggressive and resistant forms of cancer. The epidermal growth factor receptor (EGFR) is a receptor that Read More