Current Drug Research Reviews - Online First
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21 - 24 of 24 results
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Plant Endophytes and their Secondary Metabolites: A Source of Bioactive Compounds
Authors: Smita Narwal, Gurvirender Singh, Neha Yadav, Preeti Garg, Nisha Grewal and Ashwani K. DhingraAvailable online: 23 April 2025More LessPlant endophytes are microorganisms in plant tissues that help generate many secondary metabolites that are responsible for biological activity. These naturally occurring chemicals have lured the attention of researchers due to their applications in the fields of healthcare, agriculture, and cosmetics. Endophytic metabolites in the pharmaceutical field play an imperative role in the treatment of anticancer, anti-inflammatory, and antioxidant agents. These features provide opportunities for new medication development, especially for conditions where present treatments are inadequate. Similarly, in the field of cosmetics, these metabolites provide advantages such as anti-aging properties and the ability to preserve the skin, thereby creating opportunities for the development of natural and efficient skincare solutions. Apart from this, they enhance productivity in agriculture and promote plant growth, especially by providing resistance against diseases, pests, and environmental stresses. Although such secondary metabolites have potential, there are still difficulties in extraction, purification, and standardization. Additional research and technology improvements will play a vital role in fully realizing their capabilities, ultimately leading to progress in the fields of agriculture, medicine, and cosmetics. The study explores the wide range of secondary metabolites synthesized by plant endophytes and emphasizes their biological effects against different diseases. In addition, the authors also highlighted the efficacy of these metabolites in combating infections that affect plants, humans, and animals.
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Microwave-assisted Green Extraction of Flavonoids: An Approach for the Development of Antiepileptic Agents
Available online: 21 April 2025More LessHerbal medicine has been used since ancient times for the treatment of various diseases and the improvement of human health. In research, the extraction process serves as a critical initial step for isolating and purifying key bioactive components from crude plant extracts. Despite its importance, the extraction stage often receives less attention and remains underexplored. In India, traditional techniques, such as maceration, Soxhlet extraction, steam distillation, and cold pressing, are still widely used for processing medicinal plants. However, these conventional methods suffer from limitations, including low selectivity, reduced yields, prolonged processing times, and significant environmental and safety concerns due to the extensive use of organic solvents. To address these challenges, innovative extraction techniques have emerged in recent years, offering greater efficiency, selectivity, and environmental sustainability. Notable advancements include Microwave-Assisted Extraction (MAE), Supercritical Fluid Extraction (SCFE), Accelerated Solvent Extraction (ASE), Subcritical Water Extraction (SWE), and Ultrasound-Assisted Extraction (USE). Among these, MAE has garnered significant attention for its potential to optimize extraction efficiency while minimizing resource consumption. This review provides a comprehensive comparison of different extraction methods, with a particular focus on the benefits of MAE. Furthermore, it explores the application of MAE-extracted flavonoids in the treatment of epilepsy, leveraging their proven ability to eliminate free radicals effectively. It also aims to highlight the advantages of adopting MAE in therapeutic contexts, offering novel insights into its role in enhancing the efficacy of flavonoid-based interventions. This work underscores the critical need for advancing extraction technologies to meet modern safety, environmental, and therapeutic demands.
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Repositioning Drugs: A Computational Approach
Authors: Bhawna Sharma, Iti Chauhan, Rohit Pandey, Raj Kumar Tiwari, Gaurav Kumar and Gaurav Pratap SinghAvailable online: 21 April 2025More LessComputational drug repositioning has emerged as an efficient approach to discovering new indications for existing drugs, offering lower risk and cost compared to traditional drug discovery methods. Various computational approaches have been developed, including target-based, gene-expression-based, phenome-based, and multi-omics-based methods. Recent advancements leverage diverse data sources, such as biomedical databases and online health-related information. Techniques incorporating drug structure and target information have shown promising results in predicting new drug indications. Despite significant progress, challenges remain, including data noise reduction, method ensemble, negative sample selection, and data sparseness. Overall, computational drug repositioning continues to be a valuable tool in drug discovery and development.
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Phytochemical and Phytopharmacological Insights into Argemonemexicana: Integrative Approaches in Eastern Indian Region as Folk Medicine
Authors: Omsatyam, Dharmendra Kumar, Laliteshwar Pratap Singh and Sandip ChatterjeeAvailable online: 04 April 2025More LessIntroductionArgemone mexicana, commonly known as the Mexican poppy, has earned significant recognition in the traditional healing systems of the Eastern Indian region, where it has been used for centuries as a folk remedy for a variety of diseases. The study was based on search or identified through Pubmed, Google Scholar, Science Direct, etc.
Meta-analysisPhytochemical analysis has demonstrated that the alkaloids present in A. mexicana exhibit potent antimicrobial properties, making the plant an effective natural remedy for treating infections caused by bacteria, fungi, and viruses. In addition, the plant’s flavonoids and phenolic compounds are recognized for their strong anti-inflammatory and antioxidant activities, which play a crucial role in alleviating pain, reducing inflammation, and promoting tissue repair. Furthermore, A. mexicana has shown significant analgesic effects, which support its traditional use as a pain reliever. The integration of ethnobotanical knowledge with modern pharmacological research is essential for fully unlocking the therapeutic potential of A. mexicana.
Future ScopeFuture studies must focus on comprehensive clinical trials, toxicological evaluations, and in-depth mechanistic investigations to validate the efficacy and safety of A. mexicana in human populations.
ConclusionThis review highlights the urgent need for further research to bridge the gap between traditional knowledge and contemporary scientific understanding. By advancing the study of A. mexicana, there is a significant opportunity to develop novel, cost-effective, and sustainable therapeutic agents that could serve as alternatives to synthetic drugs, particularly in regions where access to modern healthcare is limited.
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