Current Drug Research Reviews - Current Issue

BackgroundRadiation therapy is the most common modality to treat various types of cancers. The use of radiosensitizers as an adjuvant therapy to increase the sensitivity of tumors against radiation and to improve the efficiency of radiotherapy has risen over the past years. Metformin, the first-line drug in type two diabetes has attracted the researcher’s attention because of its anti-cancer and anti-proliferative properties and m Read More

BackgroundRheumatoid Arthritis (RA) is a systemic inflammatory auto-immune disorder chiefly described by synovitis followed by extra-articular manifestations of organ association such as pneumonia in addition to the clinical symptoms that cause long-term joint damage starting from the small joints and gradually progressing to the larger ones. Early diagnosis is considered a major improvement for the most desirable outc Read More

Osteoarthritis (OA) is a disease characterized by degeneration of cartilage or wear and tear. OA is a cause of disability and health issues. It is a disease that affects more than 500 million adults annually worldwide, of which India accounts for about 22 to 39% of OA patients. The most common type of osteoarthritis is knee OA. Pathogenesis of OA requires evolution in basic science and clinical research to enhance our u Read More

Adolescence is an immature but adventurous time period of exploration. Due to rapid developments of the brain with unbalanced release of neurotransmitters, adolescents are prone to impulsivity that may carry out potentially dangerous behaviors. According to the Centers for Disease Control and Prevention, more than one-third of high school students have reported the use of cannabis or marijuana in 2019, and the tr Read More

Pharmaceutical excipients play a crucial role in determining the outcome of delivered therapeutic cargo density. By far, polymers have captured the biggest share in the excipients market. This surge in demand motivated researchers to look for newer and novel polymeric platforms. Interpenetrating polymeric networks (IPN) are a class of polymer in the same polymer blend league, where two different polymer chains Read More

The global health of individuals is severely threatened by drug-resistant microorganisms. Existing antibiotics available in the market, such as penicillin, cephalosporins, new β-lactams, aminoglycosides, macrolides, lincomycin, and quinolones, are losing their effectiveness due to overuse and inappropriate prescribing, among other factors. This situation underscores the urgent need to develop new antimicrobial agents. In Read More

Pulmonary fibrosis is a disease affecting the lungs and the respiratory system that carries along a high fatality rate with no specific therapeutic approaches, making it a disorder sometimes termed as incurable. There have been various researches elaborating on the potential treatment and formulation approaches. Therapeutically effective drugs, new molecules, potential drug targets and novel delivery approaches have bee Read More

Emulgel is considered an advanced leading form of topical drug delivery system. It possesses the quality of a dual control drug mechanism for drug release as it holds the properties of both gel as well as emulsion. Emulgel is capable of overcoming the problems of the conventional route of topical drug delivery, like low spreadability and stickiness with the delivery of hydrophobic drugs, enhanced bioavailability at the local sit Read More

Chalcone derivatives continue to captivate medicinal chemists due to their modest chemistry, facile synthetic method, and promising biological activities. They have become well-known in the therapeutic and pharmaceutical industries due to their diverse biological actions. These complexes offer different features and applications in a human biological system due to the flexibility of the reactions, including antimicrobial, antin Read More

Iatrogenic diseases, also referred to as drug-induced diseases (DIDs), represent a recognized yet inadequately investigated phenomenon that may result in enduring afflictions, hospital admissions, pharmacological interventions, protracted pharmaceutical reliance, and health complications. In the contemporary era of personalized medicine, it is imperative for prescribers to remain abreast of the dynamic advancements in the f Read More

It is a known fact that Alzheimer's disease causes degeneration of the central nervous system, which progresses and causes memory loss as well as loss of cognition. For many years, extensive research has been undertaken to find out newer possibilities to fight this disease at a molecular level along with many long-standing and expensive clinical trials. Many scientific research programs have either been discarded or unsuccess Read More

BackgroundSickle cell disease is a severe genetic disorder, and searching for therapeutic strategies is indispensable for prolonged and improved life for people affected by this condition.ObjectivesThis qualitative systematic review aimed to highlight the therapeutic potential of omega-3 (n-3) in people with sickle cell disease.MethodsThe search was performed by combining sickle cell disease and n-3 descriptors in DeCS/MeSH Read More

BackgroundRalstonia mannitolilytica is an emerging opportunistic pathogen that has been increasingly reported in clinical settings. Despite its low pathogenicity in immunocompetent individuals, it poses a significant threat to immunocompromised patients, particularly those with underlying medical conditions or invasive medical interventions.ObjectivesThis study aimed to evaluate the clinical impact and management strate Read More

BackgroundAfter allogeneic organ transplantation, in order to reduce the risk of rejection, tacrolimus is given. In fact, infection is reported as one of the most common side effects of tacrolimus that might be associated with graft failure.ObjectivesThis study aims to review the association between the occurrence of infections due to toxicity following the administration of tacrolimus in organ transplant recipients.MethodsScientific lit Read More

BackgroundPancreatic neoplasm is one of the types of cancer with a high incidence and case-fatality rate.ObjectivesThis study was designed to investigate the relationship between statin intake and the risk of pancreatic cancer with a systematic review and meta-analysis approach.MethodsThis study was a systematic review and meta-analysis of studies published before 2023 in Cochrane Library, Web of S Read More

AimThe aim of this study is to evaluate radioprotective effects of Cerebrolysin (CBL) in rats' brain tissues after local irradiation.BackgroundCBL has demonstrated antioxidant, anti-inflammatory, and tissue repair properties. In this study, the radioprotective effects of CBL in the brain tissues of rats after Irradiation (IR) (50 mg/ kg) were evaluated.ObjectiveThe levels of different oxidative stress markers, including malondialdehyd Read More