Recent Advances in Drug Delivery and Formulation - Online First

Introduction Onychomycosis is a frequently occurring fungal infection that affects the nails of the fingers and toes. Infection is caused by yeasts, dermatophytes, and nondermatophyte molds. Onychomycosis should be confirmed by mycology. Diagnosis can be made by various techniques, such as microscopy, fungal culture, potassium hydroxide, polymerase chain reaction, and histopathology. This review was undertaken to Read More

Pharmaceutical excipients play a critical role in drug formulation, ensuring stability, bioavailability, manufacturability, and patient safety. While India has made progress in aligning with international excipient regulations, significant regulatory gaps persist, including inconsistent enforcement, lack of mandatory GMP compliance, and inadequate impurity testing standards. These challenges create quality inconsistencies and potentia Read More

Phytoconstituents, derived from plants, possess significant therapeutic potential but often face challenges such as poor solubility and low bioavailability, limiting their efficacy. Solid dispersion (SD) is a promising approach to improve the solubility and bioavailability of these poorly water-soluble phytoconstituents. By dispersing the active drug in a hydrophilic carrier, solid dispersion enhances the surface area of the drug, i Read More

This study explores the emerging potential of non-aqueous gels for topical therapy, examining their unique properties, diverse applications, and the challenges involved in their formulation and clinical use. By highlighting these aspects, the article aims to shed light on the future of localized drug delivery and inspire further research and innovation in this promising field. Additionally, the article addresses the critical need for regula Read More

Introduction The extrusion-spheronization process continues to be utilized in pharmaceutical manufacturing, as evidenced by several recent patents and articles. The primary challenge in pelletization via extrusion spheronization is optimizing the production process to achieve high yields of spherical pellets while keeping production costs low. Therefore, this study aimed to identify the ideal parameters for maximizing prod Read More

Advanced drug delivery methods have emerged mainly because of the limitations of traditional drug delivery systems like oral and intravenous routes, along with fluctuating concentrations of drugs that have compromised therapeutic outcomes. An implantable drug delivery system (IDDS) presents an attractive alternative: long-term, continuous drug release improves therapeutic efficacy while minimizing toxicity and side e Read More

Introduction Type 2 Diabetes Mellitus (T2DM) is a prevalent metabolic disease significantly impacting healthcare, characterized by increased blood glucose levels from the average level due to insulin resistance or a lack of insulin production. Canagliflozin Hemihydrate (CGN) is one of the drugs of choice in the treatment of the disease. However, CGN belongs to BCS class IV making it difficult to formulate into suitable dosage for Read More

Introduction Azadirachta indica is also referred to as margosa or neem. It is found throughout the Indian subcontinent. Aegle marmelos L. (family: Rutaceae), sometimes referred to as Bael in Hindi, is a crucial food plant in India. The fruit has traditionally been used for the treatment of inflammation, diabetes, respiratory disorders, diarrhea, and dysentery. Aegle marmelos fruits are abundant in coumarins, carotenoids, t Read More