Anti-Infective Agents - Volume 23, Issue 4, 2025

The Marburg virus (MARV), which belongs to the family Filoviridae, is the cause of Marburg virus disease (MVD), a disease that can be fatal. Laboratories employees of Marburg and Frankfurt cities of Germany, and Belgrade city of Yugoslavia (now Serbia), contracted an infection caused by a hitherto unidentified infectious pathogen in August 1967. According to the World Health Organization (WHO), MARV is one of the m Read More

DNA gyrase is a type II topoisomerase enzyme that can cause negative supercoiling in DNA by using the energy produced by ATP hydrolysis. There are two main types of topoisomerases: type I and type II. Type I enzymes cut a single strand of DNA and are further classified as type IA if they connect to a 5′ phosphate of DNA, or type IB if they link to a 3′ phosphate. Type II topoisomerases break both strands, creating a stagge Read More

Staphylococcus aureus is amongst those microorganisms that have the ability to cause broad-spectrum infections. The bacteria can be both hospital and community-acquired due to the resistance mechanism developed against the available antibiotics. As the bacteria is resistant to almost all β-lactam antibiotic family, its treatment is becoming increasingly difficult. Therefore, new strategies should be implemented t Read More

BackgroundSulphamethoxazole-based Schiff-base compounds display potential antibacterial and antifungal activity. Sulphamethoxazole is considered to be a versatile pharmacophore that can be utilized for designing and developing numerous bioactive lead compounds. In this work, some new sulphamethoxazole-based Schiff base compounds were synthesized, which are expected to possess antimicrobial activity, ma Read More

BackgroundConcerns about infections resulting from bacterial biofilm formation in invasive devices such as catheters and prostheses are becoming widespread in the public health domain. Staphylococcus haemolyticus, a coagulase-negative bacterium, and Candida albicans, a yeast, have become recurrent pathogens of these diseases because their presence in these devices enhances the likelihood of infection. It is believe Read More

BackgroundPlants contain a large number of molecules with various potentials, including antifungal impact. Cryptococcus neoformans (C. neoformans) is a yeast that causes Cryptococcosis infection in both immunocompromised and normal individuals worldwide.ObjectiveThis study aimed to investigate the inhibitory impact of plant extracts on C. neoformans and perform purification of the most bioactive product for Read More

BackgroundMicrobes are a rich source of antibacterial and anti-insect molecules. Due to rising antibiotic and anti-insect resistance in various sectors of the society, it is important to identify new compounds that may address these issues.Aims and ObjectiveThis study aimed to explore the bacteria isolated from soil to identify new molecules with antibacterial and anti-insect activity. Further, the current study is aimed at testi Read More

BackgroundThis study explores the antimicrobial, antifungal, and insecticidal properties of Scolymus grandiflorus essential oil, examining its potential uses in the fields of pharmacology and agriculture.Materials and MethodsThe essential oil obtained by hydrodistillation was studied by GC and GC/MS. The antibacterial capacity of the essential oil was determined against two Gram-positive and three Gram-negative bacterial Read More

Malaria is caused by protozoan parasites and is a significant contributor to global mortality and morbidity. The main reasons for the resurgence of malaria are the emergence of drug-resistant strains of the parasite and the ineffectiveness of current treatment. Pyrazole-based drugs play a crucial role in medicinal chemistry due to their diverse pharmacological properties. The pyrazole structure, a five-membered ring with t Read More

BackgroundHuman papillomavirus infection, a prevalent global sexually transmitted disease, is linked to various malignancies like cervical cancer, head-and-neck squamous cell carcinoma, and anal cancer. Researchers are actively exploring phytoconstituents from medicinal plants.ObjectiveThis in silico study aims to assess the anti-human papillomavirus capabilities of phytochemical compounds sourced from Read More

IntroductionCancer, diabetes, and infection of bacteria and fungi are serious issues in the world. Synthesis of the potential drugs against them is a major challenge to the researcher. Hence, coordination chemistry has attracted researchers as it has various applications in medicinal and biological fields.MethodsSynthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and VO(II) m Read More

BackgroundThe urgent need for new antimicrobial compounds arises from the growing threat of multidrug-resistant human pathogens responsible for infectious diseases. The indole moiety, a prevalent heterocyclic ring system found in nature, is a key structural element in many pharmaceutical agents due to its wide range of biological activities. Bis(indolyl)methanes, in particular, have emerged as promising candidates for antib Read More

Nipah virus (NiV), a bat-borne infection, was first identified in Malaysia 20 years ago and has since caused outbreaks in South and Southeast Asia. NiV leads to severe respiratory and neurological conditions, is often fatal, and is highly contagious, spreading through close contact with infected individuals or animals. The virus exhibits varied clinical and epidemiological traits, necessitating rapid infection control measures to prev Read More

The traditional use of antiseptics, chemotherapeutic, expectorant, mucolytic drugs, and oxygen gas by artificial ventilation does not effectively eliminate hypoxemia in sputum, mucus, pus, and blood asphyxia in COVID-19. The emergency conversion of sputum, mucus, pus, and blood into oxygenated foam inside the airways utilizing the enzyme catalase and warm alkaline hydrogen solutions (WAHPSs) is proposed as a pro Read More