Skip to content
2000
Volume 23, Issue 4
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Background

Concerns about infections resulting from bacterial biofilm formation in invasive devices such as catheters and prostheses are becoming widespread in the public health domain. , a coagulase-negative bacterium, and , a yeast, have become recurrent pathogens of these diseases because their presence in these devices enhances the likelihood of infection. It is believed that these microorganisms produce biofilms, which complicate treatment and slow the patient´s recuperation. Dalbavancin is a semisynthetic, lipoglycopeptide-class antibiotic utilized as an anti-infective agent to break down gram-positive bacteria biofilms. Anidulafungin is an echinocandin class antifungal medication that works very well against resistant yeast strains and removes biofilms.

Objective

This study aims to examine the anti-infective agents´ tolerance to the biofilms of and

Methods

Polymicrobial biofilms were grown in a CDC Biofilm Reactor (CBR) for use in experiments.

Results

When dalbavancin maintained its antibiotic activities against in comparison with their activity against the sessile forms, the antifungal anidulafungin lost efficacy in eliminating .

Conclusion

The planktonic forms of microbes are examined in relation to the tolerance to these anti-infective drugs.

Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/aia/10.2174/0122113525326372240828105906
2024-09-10
2025-08-13
The full text of this item is not currently available.

References

  1. DanielB. SaleemM. NaseerG. FidaA. Significance of Staphylococcus haemolyticus in hospital acquired infections.J. Pioneer. Med. Sci.201443119125
    [Google Scholar]
  2. BakthavatchalamY.D. SudarsanamT.D. BabuP. MunuswamyE. Muthuirulandi SethuvelD.P. Devanga RagupathiN.K. VeeraraghavanB. Methicillin-susceptible teicoplanin-resistant Staphylococcus haemolyticus isolate from a bloodstream infection with novel mutations in the tcaRAB teicoplanin resistance operon.Jpn. J. Infect. Dis.201770445846010.7883/yoken.JJID.2016.482 28250264
    [Google Scholar]
  3. SadanandanB. VijayalakshmiV. AshritP. BabuU.V. Sharath KumarL.M. SampathV. ShettyK. JoglekarA.P. AwaknavarR. Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans.PLoS One2023186e028103510.1371/journal.pone.0281035 37315001
    [Google Scholar]
  4. Salmanton-GarcíaJ. CornelyO.A. StemlerJ. BaraćA. SteinmannJ. SivákováA. AkalinE.H. Arikan-AkdagliS. LoughlinL. ToscanoC. NarayananM. RogersB. WillingerB. AkyolD. RoilidesE. LagrouK. MikulskaM. DenisB. PonscarmeD. ScharmannU. AzapA. LockhartD. BicanicT. KronF. ErbenN. Rautemaa-RichardsonR. GoodmanA.L. Garcia-VidalC. Lass-FlörlC. GangneuxJ.P. TaramassoL. RuizM. SchickY. Van WijngaerdenE. MilacekC. GiacobbeD.R. LoganC. RooneyE. GoriA. AkovaM. BassettiM. HoeniglM. KoehlerP. Attributable mortality of candidemia – Results from the ECMM Candida III multinational European observational cohort study.J. Infect.202489310622910.1016/j.jinf.2024.106229 39025408
    [Google Scholar]
  5. KongE.F. TsuiC. KucharíkováS. AndesD. Van DijckP. Jabra-RizkM.A. Commensal protection of Staphylococcus aureus against antimicrobials by Candida albicans biofilm matrix.MBio201675e01365e1610.1128/mBio.01365‑16
    [Google Scholar]
  6. ŽiemytėM. Rodríguez-DíazJ.C. VenteroM.P. MiraA. FerrerM.D. Effect of dalbavancin on staphylococcal biofilms when administered alone or in combination with biofilm-detaching compounds.Front. Microbiol.20201155310.3389/fmicb.2020.00553 32362877
    [Google Scholar]
  7. OlivaA. StefaniS. VendittiM. Di DomenicoE.G. Biofilm-related infections in gram-positive bacteria and the potential role of the long-acting agent dalbavancin.Front. Microbiol.20211274968510.3389/fmicb.2021.749685 34745053
    [Google Scholar]
  8. RogiersO. HoltappelsM. SialaW. LamkanfiM. Van BambekeF. LagrouK. Van DijckP. KucharíkováS. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies.J. Antimicrob. Chemother.201873102806281410.1093/jac/dky246 30010876
    [Google Scholar]
  9. VitálisE. NagyF. TóthZ. ForgácsL. BozóA. KardosG. MajorosL. KovácsR. Candida biofilm production is associated with higher mortality in patients with candidaemia.Mycoses202063435236010.1111/myc.13049 31943428
    [Google Scholar]
  10. BilalH. ShafiqM. HouB. IslamR. KhanM.N. KhanR.U. ZengY. Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis.Virulence20221311573158910.1080/21505594.2022.2123325 36120738
    [Google Scholar]
  11. Ecalta-anidulafunginAvailable from: https://www.ema.europa.eu/en/medicines/human/EPAR/ecalta
  12. WilsonC. LukowiczR. MerchantS. Valquier-FlynnH. CaballeroJ. SandovalJ. OkuomM. HuberC. BrooksT.D. WilsonE. ClementB. WentworthC.D. HolmesA.E. Quantitative and qualitative assessment methods for biofilm growth: A mini-review.Res. Rev. J. Eng. Technol.201764 30214915
    [Google Scholar]
  13. GoeresD.M. PedersenS. WarwoodB. WalkerD.K. ParkerA.E. MettlerM. SturmanP. Design and fabrication of biofilm reactors.Recent Trends in Biofilm Science and Technology2020718810.1016/B978‑0‑12‑819497‑3.00003‑9
    [Google Scholar]
  14. Clinical and Laboratory Standards InstituteMethods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically.Available from: file:///C:/Users/IT-ITS-047/Downloads/03-CLSIM07-A9-2012.pdf2012
    [Google Scholar]
  15. GoeresD.M. LoetterleL.R. HamiltonM.A. MurgaR. KirbyD.W. DonlanR.M. Statistical assessment of a laboratory method for growing biofilms.Microbiology2005151375776210.1099/mic.0.27709‑0 15758222
    [Google Scholar]
  16. WhiteR.L. BurgessD.S. ManduruM. BossoJ.A. Comparison of three different in vitro methods of detecting synergy: Time-kill, checkerboard, and E test.Antimicrob. Agents Chemother.19964081914191810.1128/AAC.40.8.1914 8843303
    [Google Scholar]
  17. WannigamaD.L. HurstC. HongsingP. PearsonL. SaethangT. ChantaravisootN. Singkham-inU. Luk-inS. StorerR.J. ChatsuwanT. A rapid and simple method for routine determination of antibiotic sensitivity to biofilm populations of Pseudomonas aeruginosa.Ann. Clin. Microbiol. Antimicrob.2020191810.1186/s12941‑020‑00350‑6 32169075
    [Google Scholar]
  18. Kowalska-KrochmalB. Dudek-WicherR. The minimum inhibitory concentration of antibiotics: Methods, interpretation, clinical relevance.Pathogens202110216510.3390/pathogens10020165 33557078
    [Google Scholar]
  19. KnaflD. TobudicS. ChengS.C. BellamyD.R. ThalhammerF. Dalbavancin reduces biofilms of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE).Eur. J. Clin. Microbiol. Infect. Dis.201736467768010.1007/s10096‑016‑2845‑z 27896496
    [Google Scholar]
  20. ValentínA. CantónE. PemánJ. Fernandez-RiveroM.E. Tormo-MasM.A. MartínezJ.P. In vitro activity of anidulafungin in combination with amphotericin B or voriconazole against biofilms of five Candida species.J. Antimicrob. Chemother.201671123449345210.1093/jac/dkw316 27543657
    [Google Scholar]
  21. Fernández-RiveroM. Del PozoJ. ValentínA. De DiegoA. PemánJ. CantónE. Activity of amphotericin B and anidulafungin combined with rifampicin, clarithromycin, ethylenediaminetetraacetic acid, N-acetylcysteine, and farnesol against Candida tropicalis Biofilms.J. Fungi (Basel)2017311610.3390/jof3010016 29371534
    [Google Scholar]
  22. Marcos-ZambranoL.J. Gómez-PerosanzM. EscribanoP. ZaragozaO. BouzaE. GuineaJ. Biofilm production and antibiofilm activity of echinocandins and liposomal amphotericin B in echinocandin-resistant yeast species.Antimicrob. Agents Chemother.20166063579358610.1128/AAC.03065‑15 27021323
    [Google Scholar]
  23. PereiraR. Santos FontenelleR.O. BritoE.H.S. MoraisS.M. Biofilm of Candida albicans: Formation, regulation and resistance.J. Appl. Microbiol.20211311112210.1111/jam.14949 33249681
    [Google Scholar]
  24. BernardC. GirardotM. ImbertC. Candida albicans interaction with Gram-positive bacteria within interkingdom biofilms.J. Mycol. Med.202030110090910.1016/j.mycmed.2019.100909 31771904
    [Google Scholar]
/content/journals/aia/10.2174/0122113525326372240828105906
Loading
/content/journals/aia/10.2174/0122113525326372240828105906
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test