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2000
Volume 23, Issue 4
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Background

Human papillomavirus infection, a prevalent global sexually transmitted disease, is linked to various malignancies like cervical cancer, head-and-neck squamous cell carcinoma, and anal cancer. Researchers are actively exploring phytoconstituents from medicinal plants.

Objective

This study aims to assess the anti-human papillomavirus capabilities of phytochemical compounds sourced from and plants.

Methodology

Through studies, the anti-human papillomavirus capabilities of these compounds were assessed, focusing on their binding affinity to viral E6 protein. Phytochemicals absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis gauged drug-likeness and toxicity.

Results

Notably, compounds like Tinosporaside, β-sitosterol, β-sitosteryl-D-glucoside, botulin, ∞-amyrin, and ß-amyrin exhibited strong binding affinity.

Conclusion

These findings provide insights for drug design, encouraging further and analyses.

© 2025 Bentham Science Publishers
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In silico Approaches for Investigation of the Natural Therapeutic Agents for Human Papillomavirus: Computer-aided Drug Design Perspective
Anti Infect. Agents 23, E22113525324132 (2025); https://doi.org/10.2174/0122113525324132241121064908
/content/journals/aia/10.2174/0122113525324132241121064908
/content/journals/aia/10.2174/0122113525324132241121064908
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  • Article Type:     Research Article
Keyword(s): cervical cancer; Human papillomavirus; in silico study; medicinal plant; molecular docking; viral infection

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