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2000
Volume 23, Issue 4
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Introduction

Cancer, diabetes, and infection of bacteria and fungi are serious issues in the world. Synthesis of the potential drugs against them is a major challenge to the researcher. Hence, coordination chemistry has attracted researchers as it has various applications in medicinal and biological fields.

Methods

Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and VO(II) metal complexes were carried out. These compounds were characterized by Mass, 1H-NMR, FT-IR, Elemental analysis, Molar conductance, Magnetic susceptibility, UV-Vis., P-XRD, TGA, ., and were screened for biological activities.

Results

Synthesised azo-Schiff base ligand and its metal complexes were evaluated for their antimicrobial, antidiabetic as well as anticáncer activities against various bacteria and fungi and MCF-7 breast cancer cell line, respectively.

Conclusion

From the findings of various results, we can conclude that the synthesized metal complexes exhibit higher biological activities than the azo-Schiff base ligand.

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2025-12-31

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Synthesis, Characterization, and Anticancer, Antidiabetic, and Antimicrobial Activities of Azo-Schiff Base Ligand with ONO Donor Atom and its Transition Metal Complexes
Anti Infect. Agents 23, E22113525343891 (2025); https://doi.org/10.2174/0122113525343891240925093331
/content/journals/aia/10.2174/0122113525343891240925093331
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  • Article Type:     Research Article
Keyword(s): antibacterial; antifungal; Azo-aldehyde; metal complexes; Schiff base; α-amylase enzyme

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