Current Nanomaterials - Volume 10, Issue 2, 2025
Volume 10, Issue 2, 2025
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A Mini-review on Properties and Applications of Zinc Oxide Nanoparticles
Authors: Amruth B.A., Kushala C., Vaibhavi J.G., Rashmi V. and Sanjay K.R.In today’s world, nanoparticles play a pivotal role in revolutionizing many industries. Their nano size enables novel applications that have the potential to address pressing global challenges. The paper reviews the major properties and their practical implementations of Zinc Oxide Nanoparticles (ZnO NPs). Different methods of ZnO NP synthesis produced a surface area ranging from 57m2g-1 to 83m2g-1. A precipitation and green synthesis of ZnO NPs demonstrated its catalytic behavior. ZnOx doped with MnCO3 showed the highest catalytic activity. These properties have applications in wastewater treatment and dye removal processes in textile industries. ZnO NPs exhibit UV shielding and photocatalytic properties. ZnO NPs-coated cotton fabric is used in textile industries as it has more UV protection against uncoated cotton fabric. ZnO NPs are major semiconductors having a band gap of 3.34eV. This gives a range of applications in electrical and electronic industries. Biologically synthesized ZnO NP had better anti-microbial properties, which have a wide range of applications in the food industry, compared to chemically synthesized ZnO NP. The anti-cancer properties of ZnO NPs are due to their cytotoxicity making it a potential drug against cancer cells.
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A Review of the Current Progress of Metal-organic Framework and Covalent Organic Framework Nanocomposite Membrane in O2/N2 Gas Separation
Authors: Kok Chung Chong, Pui San Ho, Soon Onn Lai, Woon Chan Chong and Siew Hoong ShuitThe use of membrane technology has developed rapidly since the proposal of the Robeson upper bound. Nevertheless, the researchers proposed various methods and techniques to enhance the permeability and selectivity to achieve a breakthrough of the upper bound. Metal-organic framework (MOF) and covalent organic framework (COF) were the recently-interest- arising materials enhancing gas separation performance. In this study, recent advances in MOF and COF were comprehensively discussed in terms of the materials, properties and synthesis method. Later, the MOF and COF nanocomposite mixed matrix membrane development was discussed to evaluate the recent improvement of these membranes used in the O2/N2 gas separation performance. This work intends to overview the recent progress and development of the metal-organic framework, covalent organic frameworks and the used nanocomposite membrane in O2/N2 gas separation. This topic review was carried out from a thorough literature review of metal-organic frameworks, covalent organic frameworks and the used nanocomposite membrane in O2/N2 gas separation. Additionally, the recent achievement of the O2/N2 gas separation by nanocomposite membrane in term of permeability and selectivity are also discussed. Findings from this study suggested that MOF and COF-based nanocomposite membranes could be used in either the O2/N2 and N2/O2 gas separation process with the possibility of being involved in the gas production sector.
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Emerging Trends and Therapeutic Advances of Nanoparticles in the Management of Fungal Diseases: A Comprehensive Review
Authors: Diya Bhalla, Susha Dinesh and Sameer SharmaThe prevalence of fungi infections has escalated in recent decades. Even though a large portion of fatalities caused by fungal infections are preventive, there is, however, an underappreciated subject for public health officials. Nanotechnology-based carriers have garnered considerable attention owing to their exceptional capabilities. The administration of antimycotic therapeutics with enhanced antifungal activity, bioavailability, localized action, and decreased cytotoxicity has been made possible by the use of nanoparticles (NPs) as effective drug delivery systems (DDS). This burgeoning field allows cross-disciplinary researchers to design and construct multifunctional NPs capable of targeting, diagnosing, and treating mycotic diseases. This research delves into an extensive exploration of various fungal infections and their therapeutic effectiveness through the utilization of a diverse range of cutting-edge nanocarrier-based technologies. These advanced technologies encompass transfersomes, ethosomes, transethosomes, niosomes, nanoemulsions, microemulsions, micelles, as well as distinct types of nanoparticles, including polymeric, inorganic, metal, solid lipid nanoparticles, dendrimers, and carbon nanotubes. The study examines the potential of these innovative delivery systems for combating fungal infections, shedding light on their efficacy and offering insights into their promising applications. By harnessing the distinctive properties and tailored characteristics of these nanocarriers, it becomes possible to optimize the delivery of antifungal agents, thus enhancing their therapeutic outcomes.
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Recent Advances in Nanomaterial-Based Immunotherapy for Prostate Cancer: A Comprehensive Review
Authors: Amit Kumar, Akshay Kumar Lunawat, Raj Kumar Narang and Manish KumarProstate Cancer (PCa) remains a global health concern, and recent advancements in nanomaterial-based immunotherapy are reshaping the landscape of its treatment. The advent of Prostate-Specific Antigen (PSA) screening had a significant impact on the PCa burden until the early 21st century, but the ongoing innovations in therapeutic approaches and early detection methods have contributed to a decline in mortality rates. This comprehensive review delves into the evolving role of the immune system in cancer, with a particular emphasis on the latest advances in nanomaterial-based immunotherapy for PCa. The review focuses on the burgeoning field of nanomaterial-based immunotherapy for PCa, particularly in the context of vaccine-based therapies and immune checkpoint inhibitors. Recent developments in clinical trials highlight the effectiveness of immune checkpoint inhibitors, such as CTLA-4 and PD-1 inhibitors, either as standalone treatments or in combination for metastatic Castration-Resistant Prostate Cancer (mCRPC). We highlight ongoing clinical trials that explore PSMA-targeted CAR-T cells for mCRPC patients, offering valuable insights into the promising field of nanomaterial-based immunotherapy. The review also discusses nanomaterial-based vaccine treatments, such as Sipuleucel-T (Provenge®) and G-VAX. These work in different ways to boost the immune system's response to Tumor-Associated Antigens (TAAs). We also explore viral vector-based vaccines and gene therapy approaches, highlighting their potential to enhance the immune system's ability to target prostate cancer cells at the nanoscale. The article concludes with an in-depth discussion of the current and emerging nanomaterial-based biomarkers for PCa diagnosis and prognosis.
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Preparation of Nano-Metal-Oxide Incorporated Biochar for Remediation of Water Pollution
By Özgür ArarBackgroundBecause of its numerous advantages, biochar has been widely used to remove contaminants from aqueous media for several years. However, unmodified biochar often exhibits low sorption capacity. Therefore, various nano-sized metal oxides have been developed to modify biochar and improve its ability to remove impurities.
ObjectiveThis review aims to provide information on preparing and applying biochar loaded with nano-sized metal oxides to treat pollutants in water samples.
ResultsRaw biochar has limited applicability/capacity for certain pollutants, such as inorganic anions. However, modification with metal oxides improved removal performance, sorption capacity, and selectivity.
ConclusionBiochar loaded with metal oxides is believed to be an environmentally friendly alternative for treating polluted water. Selective sorbents with high capacity and fast kinetics towards undesirable solutes can be produced using suitable metal oxides. The sorbent can remove pollutants from solutions with a high removal rate.
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Nanosensors from Logistics and Supply Chain Perspective: A Literature Review
Authors: Ilknur Tunc and Goknur Arzu AkyuzIntroductionNanosensors are one of the most recent technologies obtained from the nanoworld. They have enhanced properties with potential applications in a wide spectrum of sectors. They exhibit exceptional properties in temperature monitoring, hazardous gas and vapor detection, humidity detection, as well as pathogens, toxins, and chemical contaminant detection. Among various nanosensor applications, one of the most recent usages of nanosensor technology is in logistics and supply chain management (SCM).
AimThis study aims at investigating the potential of nanosensor technology from logistics & SCM perspective, and specifically questions how can this technology contribute to food supply chains.
MethodsA systematic comprehensive literature review was conducted with the keywords: nanosensors & logistics, nanosensors & supply chain, nanosensors & smart packaging, and nanosensors & food logistics for the date range 2001-2022, covering a broad set of references. Findings revealed that nanosensors have significant potential in providing smart packaging, and improving traceability and visibility across all the logistics and SCM processes including end-to-end transportation and storage activities.
ResultsHybrids of different types of nanosensors with the existing material identification systems provide new levels of traceability and visibility in SCM, enabling accurate tracking of a variety of parameters. The study has shown that the intersection of nanotechnology and logistics & SCM domains is still immature.
ConclusionThis intersection is especially critical for food supply chains for meeting their special traceability requirements, and for serving food safety and organic food traceability across all stages of logistics.
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Environmentally Compatible Poly (Vinyl Alcohol)/Banana Peel Nano Crystals/Bentonite Clay-based Composites Films: Influence of Nano Filler on Biodegradation Behavior
Authors: Deepak kohli, D.S. Panwar, Balraj Tudu, Jigesh Mehta, Vishal Shah, Jigna Patel, Bital Patel, Ankit D. Oza, Ravi Gupta and Laxman SinghObjectiveThe present work shows the effect of Bentonite Clay (BC) on the biodegradation behavior of Poly Vinyl Alcohol (PVA)/Banana Peel Nano Crystals (BPNC) composite films.
MethodBiodegradation studies were conducted using soil burial and bacterial degradation method. The prepared composite films were characterized by scanning electron microscopy.
ResultsBiodegradation studies reported that the composite films were more degradable in bacterial environment as compared to natural soil burial. The addition of Bentonite Clay (BC) had negative effect on degradation rate of composite films.
ConclusionPVA/BPNC/BC composite film showed less weight loss (%) as compared to PVA/BPNC composite films because BC had stabilizing effect against the microbial attack which prevents biodegradation.
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Eco-friendly Synthesis of Silver Nanoparticles using Bignay (Antidesma bunius) Leaves for Antibacterial Application
Authors: Khent Ivan Duerme, Cathleen Montano, Eliezer Diamante and Noreen Grace FundadorBackgroundFoodborne pathogenic bacteria continue to become a global concern despite the advancements in food packaging technology. Silver nanoparticles (AgNPs) are widely studied in the field as they exhibit desirable inhibitory properties against foodborne pathogens. AgNPs are conventionally synthesized by toxic chemical and physical means; hence, there is a need to seek environmentally safe alternative routes for producing AgNPs.
ObjectiveThe study aimed to synthesize AgNPs using bignay (Antidesma bunius) leaf extract and assess its antimicrobial activity against the common foodborne pathogens S. aureus and E. coli.
MethodsBignay leaf extract was characterized using total phenolic content (TPC) assay and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay. AgNPs were produced under optimized pH, temperature, and incubation time and were characterized using UV-Vis spectroscopy, Fourier Transform Infrared spectroscopy, and Transmission Electron Microscopy. The antimicrobial activity of AgNPs was evaluated against S. aureus and E. coli using the Resazurin Microtiter Assay (REMA).
ResultsBignay leaf extract exhibited a total phenolic content of 0.315 ± 0.015 mg GAE/mg extract and an IC50 of 36.36 ± 0.003 μg/mL, which suggests its good reducing properties. The AgNPs synthesized under reaction conditions of pH 7, 45 ºC, and 30 min showed SPR peaks in the range of 412-426 nm. Particles were spherical with an average size of 23.72 ± 7.30 nm. FTIR analysis revealed that the phenolic compounds in the extract capped the resulting nanoparticles. AgNPs demonstrated superior inhibitory activity against S. aureus and E. coli with MIC90 values of 2.90 ± 0.03 and 3.08 ± 0.004 μg/mL, respectively.
ConclusionThe study was able to develop a green approach for the synthesis of AgNPs with antibacterial properties using bignay leaf extract.
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Antimicrobial Potency of the Biosynthesized Silver Nanoparticles (AgNPs) on Methicillin-Resistant Staphylococcus aureus (MRSA) Using Brideliaferruginea Benth Plant Extract
BackgroundAntibiotic resistance among pathogens has grown to be a major concern for the health of people around the world. One of the main subgroups of troublesome multidrug-resistant bacteria that has recently undergone rapid evolution is Methicillin-resistant Staphylococcus aureus (MRSA).
MethodsIn this study, silver nanoparticles were synthesized using an aqueous extract of Bridelia ferruginea leaves. The methicillin-resistant S. aureus was used to test the antibacterial properties of the produced Bridelia ferruginea-derived silver nanoparticles. These nanoparticles were characterized using XRD, UV-vis spectroscopy, FTIR, and SEM.
ResultsThe antibacterial activity of the silver nanoparticles was improved at doses of 50, 100, and 150 ug/ml, with mean zones of inhibition (ZOI) of 13.0, 16.4, and 17.4 mm (SD1). When combined with erythromycin medicines, silver nanoparticles showed significant antibacterial efficiency compared to when used alone. The ZOI was 23 mm at 150 ug/mL, compared to 21 mm at 50 and 100 ug/mL. At P=0.06, the outcomes were statistically significant.
ConclusionThis established that the antibacterial impact of combining antibiotics with AgNPs is enhanced. The current work showed that biosynthesized B. ferruginea silver nanoparticles (BF-AgNPs) were effective in vitro.
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An Investigation into the Additional Potential of Iron-Reducing Bacteria Harnessed for Gold Nanoparticle Synthesis
Authors: Oluwafemi Bamidele Daramola, Nkem Torimiro and Reama Chinedu GeorgeIntroductionSoil bacteria that synthesize varying metallic NPs are underreported, even though there is a promising mechanism in the bio-reduction of gold salts and the synthesis of gold nanoparticles by different bacterial species.
ObjectiveThis study aimed to explore the ancillary potential of some soil microbes obtained from a metal fabricating workshop for gold nanoparticles (AuNPs) synthesis.
MethodsTo evaluate the usefulness of these soil microbes, 1 mM chloroauric acid (HAuCl4.4H2O) was bio-reduced using the wet biomass of these bacterial cells and characterized with UV-Vis spectrophotometer, Fourier Transform Infra-red (FTIR), Scanning Electron Microscope (SEM), Energy Dispersive X-ray (EDX), and X-ray Diffractometer (XRD).
ResultsFindings from this study showed that the studied bacterial isolates synthesized AuNPs with absorbance peaks within the range of 500 and 600 nm. The FTIR analysis showed the involvement of O-H, N-H, and C=O stretch of alcohol, amine, and amide groups, respectively. The SEM images analyzed with Image J reported a mean area size between 17-184 nm. The EDX showed Klebsiella africana (C11), and Bacillus subtilis (A12) had the lowest (7.32%) and highest (51.26%) weight percentages of AuNPs, respectively.
ConclusionGold nanoparticles have been found most appropriate for several novel applications, and this work has provided further understanding of the capacity of naturally occurring bacteria to be non-selective in the bio-reduction of gold salts, hence expanding their potential uses.
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Preparation, Optimization, and in-vitro Release Study of Abemaciclib-Loaded Chitosan Nanocarrier as a New Approach for Breast Cancer Treatment
Authors: Mohammed Mohanad Ali, Samer Hasan Hussein-Al-Ali and Mike Kh. HaddadAbemaciclib (Abm) is a CDK inhibitor that specifically targets the CDK4/6 cell cycle pathway and has potential anticancer activity. Unfortunately, it has a low solubility and dissolution rate.
AimThe aim of this study is to enhance the solubility of Abm by loading it onto a chitosan (CS) polymer.
MethodsPolymer nanoparticle (NP) and Abm-CSNPs nanocomposites were prepared. Minitab 18 software was used to design 18 run samples to study the effects of CS, tripolyphosphate, and pH as independent variables on the loading efficiency and particle size (dependent variable). The response surface methodology (RSM) was also used to determine how the variables affected the response. The graphical analysis used surface plots, main effects plots, contour plots, and interaction graphs. The study includes F values, p values, variance inflation factors (VIFs), adjusted sums of square (Adj SSs), adjusted mean squares (Adj MSs) and square error of the coefficient (SE Coef). The carriers and loaded samples were also examined using the results of tests, including Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. Furthermore, the release of Abm from Abm-CSNPs nanocomposite was studied in vitro.
ResultsThe results revealed an ability to produce particle sizes ranging from (168-192) nm and loading efficiencies from (56.7-62.1).
ConclusionAbm-CSNPs nanocomposite may be used as an alternative drug delivery system for Abm to increase the release time of Abm to 1400 minutes.
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