MicroRNA - Online First
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MicroRNA: A Novel Class of Potential Biomarkers and Therapeutic Target for Non-Alcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Available online: 16 June 2025More LessNon-alcoholic fatty liver disease (NAFLD) is commonly related to metabolic-associated chronic liver disease, which has a pathological spectrum from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). It is mainly associated with other disease conditions, such as obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease. MicroRNAs (miRs) are small non- Read More
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Equine MicroRNAs: Performance, Reproduction, and Disease
Available online: 16 June 2025More LessMicroRNAs (miRNAs) are molecules that regulate gene expression by targeting the 3′ untranslated region (UTR) of mRNAs. They are essential in numerous biological processes like growth, metabolism, and muscle development. miRNA research has become crucial in livestock breeding, offering solutions for improving animal health and productivity. This review focuses on miRNAs' roles in equine performance, reproductio Read More
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AAAGUGC Seed-Containing miRNAs: Master Regulators of Cancer Pathways and Therapeutic Resistance
Available online: 26 May 2025More LessMicroRNAs have emerged as pivotal post-transcriptional regulators, orchestrating a myriad of cellular processes critical to both normal physiology and pathological conditions, particularly cancer. Among these, miRNAs containing the highly conserved AAAGUGC seed sequence have garnered significant attention due to their multifaceted roles in cancer progression, acting as both oncogenes and tumour suppressors across a wi Read More
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Exploring the Role of Non-Coding RNAs in the Gut and Skin Microbiome: Implications for Colorectal Cancer and Healthy Longevity
Available online: 08 April 2025More LessIn the last forty years, cancer mortality rates have risen by more than 40%, with colorectal cancer (CRC) ranking as the third most common kind worldwide, significantly affected by dietary factors. Restricted access to sophisticated medical treatment and insufficient comprehension of colorectal cancer's biology contribute to its elevated occurrence. Researchers have recognized dysbiosis of the gut microbiome as a criti Read More
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Role of Exosomal Non-Coding RNAs In Vivo and In Vitro Studies in Colorectal Cancer
Authors: Mohamed Y. Zaky and Hadeer M. HamdallaAvailable online: 18 March 2025More LessColorectal Cancer (CRC) is the third most lethal cancer worldwide. Complex intercellular communication within the tumor microenvironment influences cancer progression, therapeutic resistance, with Exosomes (Exos) and Circulating Extracellular Vesicles (EVs) playing a critical role in this communication. Exosomes can impact recipient cells by carrying various biomolecules, promoting changes that support cancer progres Read More
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Extrahepatic and Circulating miR-122: Diagnostic Implications and Future Directions
Authors: Rachel Sarah Royfman, Joseph Riley Mctague, Meghana Ranabothu and Bindu MenonAvailable online: 23 January 2025More LessResearch on microRNAs is constantly expanding and evolving due to their role in the regulation of gene expression. miR-122, a 22-nucleotide microRNA, was first discovered as a liver-specific miRNA. Subsequently, it was found to be present in a wide range of tissues, such as the breast, testes, ovaries, and heart. The research on miR-122 in the liver has been extensive over the past few decades, leading to several import Read More
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micro-RNA 451-a as a Circulating Biomarker for Neuroblastoma
Available online: 10 January 2025More LessIntroduction Micro ribonucleic acids (miRNAs) are small non-coding RNAs that modulate the expression of various genes. They have an important role in cancer pathogenesis. Differential expression of multiple miRNAs have been used as potential diagnostic and prognostic markers. Methods Various cancers have lately been employed as therapeutic targets. This prospective study included untreated pediatric neuroblastoma ( Read More
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The Role of Noncoding RNAs in the Prognosis and Diagnosis of Colorectal Cancer: An Emerging Biomarker
Authors: O. Surekha Vani, Kavitha R Thangaraj, Varshaa Ravichandran and Solomon F. D PaulAvailable online: 26 November 2024More LessColorectal cancer has become the leading cause of death worldwide, and it is the second most common cancer in women and the third most common cancer in men. Accumulating evidence suggests that genetic and epigenetic factors play a key role in the development of colorectal cancer. Cancer Stem Cells (CSC) play an important role in the suppression or development of cancer in various conditions. In recent yea Read More
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Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing
Authors: Bhawna Sharma, Iti Chauhan, Gaurav Kumar, Khushboo Bhardwaj and Raj Kumar TiwariAvailable online: 31 October 2024More LessThe revolutionary CRISPR/Cas9 gene editing technology holds immense potential for treating genetic diseases and tackling conditions like cancer. However, efficient delivery remains a significant challenge. This is where nanoparticles come into play, emerging as powerful allies in the realm of drug delivery. Nanoparticles can accommodate larger insertion sizes, enabling the incorporation of larger Cas9 enzymes and complex g Read More
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