Current Organic Chemistry - Volume 29, Issue 17, 2025

Metformin is a popular biguanide medicine because of its efficacy and inexpensive cost. Over time, other applications of metformin were found, and the advantages of metformin for diverse conditions such as anticancer, anti-inflammatory, anticoagulant, antimicrobial, and many more were studied. Although the underlying mechanism of these numerous benefits remains unknown, repurposing it is a smart concept, as it offer Read More

This review examines the reactivity of bis(α-cyanoacetamides) attached to various spacers in producing heterocyclic and macrocyclic molecules. Bis(α-cyanoacetamides) contain two electrophilic and three nucleophilic sites, allowing for multiple coupling reactions. They are regarded as potent chemical reagents capable of producing various heterocyclic derivatives with potential biological applications. The current review covers Read More

Kojic Acid (KA) is an oxygen-based heterocycle of natural occurrence and is chemically known as 5-hydroxy-2-(hydroxymethy1)-4H-pyran-4-one. This review has been designed to lighten up the various biological potentials, including the tyrosinase inhibition potential and depigmenting action of KA and its derivatives. KA has very interesting physical and chemical properties and has many applications in the medicinal and cosmeti Read More

Organic reactions involve the breaking and formation of bonds, particularly sigma bonds (single bonds) and pi bonds (double and triple bonds). Organic chemists are often more interested in how a reaction works than in why it occurs. With foreknowledge and experience of the reaction details, chemists can generate new compounds and provide a sequential description of each step in the transformations that result in n Read More

Several studies have reported that aldol condensation of various cyclic and acyclic ketones with aromatic aldehydes leads to the formation of symmetrical bisarylidene derivatives, while efficient synthesis of mono- and dissymmetric bisarylidenes is not very common and only a limited number of related reports are available. In the present work, a new one-pot method is designed and performed to synthesize dissymme Read More

Gossypol has been shown to be a promising natural product for the anticancer drug development for treating leukemia, lymphoma, colon carcinoma, breast cancer, and other malignant disease. It is known that the conversion of aldehyde groups of gossypol into iminofragments by the treatment of various amines can reduce the toxicity of the derivative and simultaneously increase their pharmacological efficacy. This ar Read More

Using ultrasound, the synthesis of substituted 2-amino (or 2-alkoxy) benzimidazoles through a multi-component, one-pot reaction of 2-iodoaniline and amine (or alcohol)-trichloroacetonitrile (CCl3CN) adduct with the help of a catalytic amount of copper(I) iodide in dimethylformamide at room temperature has been presented. Using basic materials, simple and available reagents, gentle copper-catalyzed reaction conditions, eas Read More