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2000
Volume 29, Issue 17
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Using ultrasound, the synthesis of substituted 2-amino (or 2-alkoxy) benzimidazoles through a multi-component, one-pot reaction of 2-iodoaniline and amine (or alcohol)-trichloroacetonitrile (CClCN) adduct with the help of a catalytic amount of copper(I) iodide in dimethylformamide at room temperature has been presented. Using basic materials, simple and available reagents, gentle copper-catalyzed reaction conditions, easy purification with the help of solvent, decent efficiency, applying a simple and efficient sonochemical method, reacting in the shortest time, and finally, the synthesis of 18 new heterocycle compounds are appreciable features of this protocol.

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2025-10-05
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