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Using ultrasound, the synthesis of substituted 2-amino (or 2-alkoxy) benzimidazoles through a multi-component, one-pot reaction of 2-iodoaniline and amine (or alcohol)-trichloroacetonitrile (CCl3CN) adduct with the help of a catalytic amount of copper(I) iodide in dimethylformamide at room temperature has been presented. Using basic materials, simple and available reagents, gentle copper-catalyzed reaction conditions, easy purification with the help of solvent, decent efficiency, applying a simple and efficient sonochemical method, reacting in the shortest time, and finally, the synthesis of 18 new heterocycle compounds are appreciable features of this protocol.
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