Current Organic Chemistry - Current Issue

Natural compounds are pivotal sources for synthesizing a vast array of biologically active substances in chemistry. Camphor is one of these substances, and both enantiomers are readily obtainable and play significant roles in various synthetic and therapeutic applications. This mini-review provides information on a few synthetic routes for camphor production that have been documented over time. It presents several rearrangements that this chemical and its derivatives can undergo to showcase possible starting points for new compounds that may have biological activity.

Mangiferin always draws the attention of traditional as well as modern medicinal chemists because of its ease of chemical derivatization and diverse biological activities, including anticancer, anti-inflammatory, neuroprotective, antidiabetic, analgesic, antimalarial, anticonvulsant, laxative, cardiotonic, hemopoietic, antioxidant, antimicrobial, antipsychotic, anticoagulant, and antihypertensive properties. This review focuses on a detailed and updated overview of the synthesis of mangiferin derivatives and their diverse biological activities, with examples from both patented and non-patented literature.

N-Chlorosuccinimide (NCS) is a five-membered N-containing heterocyclic molecule. This is a versatile reagent and is successfully employed for different types of reactions. Initially, this was employed for chlorination only but soon became an excellent reagent for many reactions, including halocyclizations, functional group transformations, formation of carbon-carbon bonds, etc. This review article covers representative applications of NCS for aliphatic and aromatic chlorination, chlorination of atoms other than carbon, oxidation, and other reactions.

Carbazole derivatives possess tricyclic structure consisting of two benzene rings fused on both sides with the central pyrrole ring. These compounds diversely appear both in natural and synthetic sources. Carbazole-based compounds have a wide range of bioactivities such as antimicrobial, anticancer, antiparasitic, antihypertensive, antineuropathic, and anti-inflammatory activities. Some carbazole derivatives have been employed as drugs in the market. The synthesis of carbazole derivatives has attracted intensive interest from chemists and a huge number of studies on the synthesis of carbazole-based compounds have been published over the years. In this article, we will give a comprehensive review of studies on the synthesis of carbazoles, which date back to 2012. One hundred twenty-six studies on the synthesis of carbazoles are summarized. A huge number of novel methods have been developed to improve efficiency or employ environmentally benign procedures. In most cases, reaction mechanisms were included. The review article might be useful for chemists who work in the synthesis of heterocycles or drug chemistry.

This work is devoted to the theoretical study of methylaluminoxanes formed by the interaction of trimethylaluminum with water. The main goal of this work is to identify the most likely molecular form of methylaluminoxane formed in the reaction mixture. Quantum chemical calculations were carried out within the framework of density functional theory, at the PBE0/def2-TZVP level. The work analyzes the thermodynamic parameters of the reactions of the formation of various structures of methylaluminoxanes. On the base of the obtained results, it was concluded that the most probable structure formed in the reaction mixture under real synthesis conditions should be considered Al2O(CH3)4.