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image of Advancements and Implementations of Injectable Hydrogels in the Medical Field: A Comprehensive Review

Abstract

Innovations in the development and application of injectable hydrogels within biomedical engineering highlight their distinct characteristics and promising roles in tissue engineering and controlled release systems. Injectable hydrogels, distinguished by their three-dimensional network topologies, in-situ gelation process, and stimuli-responsive behaviour, have outstanding biocompatibility, mechanical properties, and the capacity to deliver therapeutic drugs to specific areas with little invasiveness. This review focuses on the advancements in hydrogel formulations, particularly natural and synthetic hydrogels, and their effectiveness in stimulating tissue regeneration. It specifically emphasizes cardiac applications following myocardial infarction. Hydrogels have received significant attention due to their exceptional porosity, mechanical behaviour, and biological compatibility, making them convenient for cancer therapy. Injectable hydrogels, known for their favourable physicochemical properties, have shown promising results in treating various conditions, including ocular diseases, cancer, wound healing, cardiovascular disorders, and rheumatoid arthritis. It highlights the diversity in study methodologies and the necessity for large-scale animal trials, which pose challenges for clinical translation. Furthermore, emphasizes the importance of enhancing hydrogel properties to improve therapeutic efficacy and calls for additional research to fully realize their potential in regenerative medicine. This study explores injectable hydrogels for cardiac tissue regeneration post-myocardial infarction (MI), a less-studied area compared to wound healing and drug delivery. It highlights their applications in ocular diseases, cancer therapy, rheumatoid arthritis, and personalized medicine, addressing challenges like clinical translation, biocompatibility, and mechanical property optimization. Emphasis is placed on improving hydrogel porosity, strength, and stimuli-responsiveness for enhanced outcomes. Unique insights include their role as targeted drug carriers for localized cancer therapy. Future directions involve biopolymer innovations, 3D bioprinting, and regenerative medicine advancements.

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2025-10-15
2026-02-01

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/content/journals/ddl/10.2174/0122103031371020251005051531
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Advancements and Implementations of Injectable Hydrogels in the Medical Field: A Comprehensive Review
Bentham Science Publishers ; https://doi.org/10.2174/0122103031371020251005051531
/content/journals/ddl/10.2174/0122103031371020251005051531
/content/journals/ddl/10.2174/0122103031371020251005051531
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  • Article Type:     Review Article
Keywords: Drug delivery systems ; hydrogel classification ; stimuli responsive hydrogels ; tissue regeneration ; smart hydrogel ; cardiac tissue engineering ; bone cell growth

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