Current Nutrition & Food Science - Volume 21, Issue 9, 2025
Volume 21, Issue 9, 2025
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Nutraceutical Strategies for Enhancing Celiac Disease Management: A Review of Current Evidence
More LessCeliac disease is an autoimmune disorder that can be triggered by the intake of a protein called gluten. Currently, a rigorous gluten-free diet is the only treatment available for celiac disease. However, recent research has shown that certain nutraceuticals may have potential in managing the symptoms of celiac disease. Nutraceuticals are food-derived products that provide health benefits beyond basic nutrition. This review investigates the functions of nutraceuticals in the management of celiac disease, including their potential for reducing inflammation, modulating the gut microbiota, and improving nutrient absorption. The potential benefits of various nutraceuticals, including probiotics, prebiotics, polyphenols, and enzymes, are discussed. Although further investigation is required to completely comprehend the effectiveness of nutraceuticals in the treatment of celiac illness, current evidence suggests that they may be a promising avenue for improving the quality of life for those with this condition. The management of celiac disease involves a multidisciplinary approach that includes diagnosis, education, and ongoing support. The key to successful management of celiac disease is early and accurate diagnosis, followed by education on the gluten-free diet and the avoidance of cross-contamination. This can be challenging, especially for those who are newly diagnosed, but with proper guidance and support, individuals with celiac disease can lead healthy and fulfilling lives. Sustained monitoring and follow-up treatment are also necessary to make sure the gluten-free diet is followed and to identify any possible issues.
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Triptolide-induced Pyroptosis: A Promising Strategy for Cancer Therapy
More LessAuthors: Gyas Khan, Sarfaraz Ahmad, Ajay Singh Bisht, Ayesha Sultana and Md Sadique HussainTriptolide (TPL), a diterpenoid epoxide, exhibits multifaceted anticancer properties, including the induction of diverse Programmed Cell Death (PCD) mechanisms, such as apoptosis, autophagy, pyroptosis, and ferroptosis. Its ability to modulate signaling pathways, transcriptional activity, and interactions with noncoding RNAs underscores its potential as a versatile therapeutic agent. The apoptotic effects of TPL are well-documented across multiple cancer types. Recent evidence highlights TPL’s role in inducing pyroptosis, particularly through the Gasdermin-E (GSDM-E) pathway, which enhances tumor immunogenicity and stimulates antitumor immunity within the tumor microenvironment (TME). By disrupting mitochondrial membrane potential and inflammasome activation, TPL initiates pyroptotic cell death while modulating immune-related pathways, such as the NF-κB/NLRP3 inflammasome axis. Moreover, TPL’s ability to trigger autophagy and ferroptosis independently or in synergy with other PCD pathways enhances its therapeutic promise. The integration of TPL into cancer treatment protocols offers novel strategies, particularly in combination with immunotherapy, by enhancing immune effector responses and suppressing the pro-tumorigenic polarization of tumor-associated macrophages. However, the clinical translation of TPL faces challenges, including toxicity and the need for optimized delivery systems. Advanced research into TPL derivatives and innovative drug delivery frameworks, such as metal-organic frameworks, is crucial for mitigating side effects while preserving therapeutic efficacy. This review underscores TPL’s potential to redefine cancer therapy by harnessing its unique capacity to induce pyroptosis and other PCD forms, paving the way for its inclusion in next-generation oncological treatment paradigms.
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Symptoms and Types of Migraine Headaches, and Their Preventive Measures
More LessAuthors: Umesh C. Gupta and Subhas C. GuptaMigraines are complex neurological disorders and a leading cause of disability worldwide, particularly among adults under 50. Despite its high prevalence, the underlying mechanisms remain partially understood. Its treatment often requires a multifactorial, personalized approach. This narrative review addresses a key gap in the literature by integrating recent findings across pharmacological, dietary, environmental, and lifestyle domains to propose a more holistic framework for migraine prevention and management. The study outlines common migraine subtypes, triggers, and pathophysiological features, emphasizing the role of the gut-brain axis, hormonal shifts, and environmental stressors. Evidence supports the effectiveness of interventions such as CGRP antagonists, plant-based diets, sleep regulation, and physical activity. Visual schematics illustrate the progression of migraine, including a proposed flowchart linking triggers to symptoms and a conceptual diagram of the gut-brain axis. While recent therapies show promise, further research is needed to validate integrative strategies, optimize personalized treatment, and explore novel biological targets. Improving awareness and access to such strategies could significantly enhance the quality of life for millions affected by this disabling condition.
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Vitamin E and Folic Acid as Nutritional Modulators of Neurodevelopment: A Functional Food Perspective
More LessNeurodevelopment is a highly regulated and complex process that involves cellular proliferation, differentiation, and synaptic maturation. Nutritional factors, such as vitamin E and folic acid, play pivotal roles in this process. Vitamin E, primarily in the form of α-tocopherol, functions as a potent antioxidant, maintaining neuronal membrane integrity and supporting key neurodevelopmental processes through its interaction with α-TTP. Likewise, maternal folate intake has been extensively linked to positive neurodevelopmental outcomes, including reduced risk of neural tube defects and enhanced cognitive performance in offspring. Folic acid also modulates epigenetic processes, such as DNA methylation of genes essential for neuronal development, including IGF2 and BDNF. Studies in both murine and zebrafish models confirm the crucial role of these nutrients in brain development and function.
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Effect of Yeast (Saccharomyces cerevisiae) on Blood and Intestinal Histopathology of Nile Tilapia (Oreochromis niloticus)
More LessBackground: Aquaculture advises against using antibiotics and synthetic hormones for tilapia fish growth due to concerns about antimicrobial resistance, environmental contamination, and disruption of the fish microbiome. The search for alternative fish growth promotion strategies has been an extensive one. The effect of yeast (Saccharomyces cerevisiae) on intestinal histology, biochemical parameters, and haematology indices of Oreochromis niloticus is examined in this study.
MethodsTo produce the experimental diet of 35% crude protein, yeast at varying quantities were added to the basal feed ingredient in the following amounts: 0, 5, 10 and 15 g/kg, which corresponded to the groups G1 (control), G2, G3, and G4, respectively. Twelve (12) concrete ponds, each with a capacity of 1,500 litres, were the culture structures for the experiment. Two hundred and forty mixed-sex Oreochromis niloticus fingerlings were stocked, and each pond was randomly allocated twenty fingerlings. Each parameter assessed was replicated 3 times.
ResultsThe result on growth parameters showed that the highest final mean weight (86.33 ± 3.51 g), average daily growth (1.14 ± 0.05 g), percentage mean weight gain (278.05 ± 4.59%), and Specific Growth rate (7.41 ± 0.08 g) were obtained in G3 fed with 10g/kg of Saccharomyces cerevisiae. While the lowest final weight (38.00 ± 4.58 g), average daily growth (0.28 ± 0.07 g), percentage mean weight gain (68.23 ± 16.66%), Specific Growth rate (4.84 ± 0.50 g) was obtained in G1, fish fed with control diet. The study's results on blood parameters indicate that the O. niloticus fed 5 g/kg of yeast in G2 had the highest mean values of Red Blood Cells at 4.49 ± 0.23 × 106 µ/l, Haemoglobin at 3.73 ± 0.20 g/dl, and Mean Cell Haemoglobin Content at 46.03 ± 0.07. While the fish fed 15 g/kg of yeast in G4 had the lowest mean values of 3.48 ± 0.35 × 106 µ/l, 3.73 ± 0.31 g/dl, and 31.80 ± 0.05, respectively. The greatest mean values of White Blood Cells at 10.53 ± 0.35 × 103 µ/l, Parked Cell Volume at 15.50 ± 0.50%, and Mean (red) Cell Volume at 38.08 ± 0.06 were observed in fish fed with the control diet. Fish given 5 g/kg (G2) had the greatest levels of total protein, glucose, globulin, and cholesterol, with mean values of 62.00 ± 0.93 g/dl, 14.30 ± 0.20 g/dl, 48.00 ± 1.00 and 3.34 ± 0.05 g/dl respectively.
ConclusionThe study suggests that increasing yeast concentration in O. niloticus diets increases mucosa surface area and promotes nutrient absorption, with minimal adverse effects on intestinal histology, biochemical parameters, and haematology indices of Oreochromis niloticus.
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Effectiveness of Moringa oleifera L. Extract and Royal Jelly in Addressing Toddler Malnutrition in Coastal Central Sulawesi
More LessAuthors: Hasan Basri, Veni Hadju, Rahayu Nurul Reski, Ahmad Arif Hidayat and Muh Agung SaharuddinIntroductionMoringa oleifera and honey are nutrient-rich local foods with the potential to combat malnutrition. Combining them may enhance their synergistic effects, offering a holistic nutritional solution.
ObjectiveThis study assessed the impact of Moringa oleifera plus royal jelly (MRJ) capsules on the weight, height, and nutritional status of toddlers in high-stunting coastal areas of Tojo Una-Una District.
MethodsA quasi-experimental design was used, with an intervention group receiving 500 mg of MRJ capsules daily for three months, and a control group with similar baseline characteristics. The study involved six high-stunting villages, with nutrition workers monitoring compliance. Height and weight were measured using standardized tools, while dietary intake was assessed via 24-hour recall. Data were analyzed using WHO Anthro 2006, NutriSurvey 2007, and JASP.
ResultsBaseline characteristics and food intake were similar between groups. Post-intervention, significant differences were observed in weight (9.00 ± 1.29 kg vs. 8.45 ± 0.93 kg, p=0.042) and height (76.57 ± 3.43 cm vs. 74.23 ± 5.30 cm, p=0.041). The intervention group also showed greater improvements in weight gain (0.99 ± 1.3 kg vs. 0.26 ± 0.7 kg, p < 0.005) and height increase (5.01 ± 2.8 cm vs. 2.83 ± 4.2 cm, p = 0.019). Additionally, HAZ scores improved significantly in the intervention group (-1.96 ± 1.24 to -1.55 ± 0.96, p = 0.027).
DiscussionThe findings align with previous research highlighting Moringa’s role in combating malnutrition. However, limitations include the non-RCT design, lack of a placebo group, and small sample size.
ConclusionMRJ supplementation significantly improved weight, height, and HAZ in toddlers, suggesting its potential as a nutritional intervention in areas prone to stunting. Further randomized trials are recommended to validate these results.
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Spatial Analysis of Nutritional Status in Children Under Five in East Java, Indonesia: Identifying Priority Intervention Areas Using 2018-2023 Provincial Data
More LessAuthors: Widati Fatmaningrum, Raudia Faridah Humaidy, Shafira Meidyana and Lilik DjuariIntroductionReducing global stunting rates is a critical focus of the Sustainable Development Goals (SDGs), particularly under the objectives of zero hunger, good health and well-being. Indonesia has set a target to reduce the prevalence of stunting to 14%. However, as of 2023, the national prevalence remains at 21.5%, with East Java, a densely populated region, reporting a rate of 19.2%. This study aimed to identify risk factors for nutritional problems among infants and toddlers in East Java to guide region-specific interventions and serve as a global model for addressing stunting and nutritional issues.
MethodsData was collected from provincial health registries and analysed for trends and associations using STATA18 and spatial distribution using QGIS3.34. Factors examined included community participation, ferrous supplementation during pregnancy, newborn birth weight, exclusive breastfeeding rates, vitamin A supplementation, and child nutritional status monitoring.
ResultsWhile the prevalence of underweight, stunted, and wasted children showed a decreasing trend, critical factors such as ferrous supplementation in pregnant women, exclusive breastfeeding rates, and vitamin A supplementation also exhibited declines. Early and exclusive breastfeeding and vitamin A supplementation were significantly associated with underweight status.
DiscussionImprovements in child nutritional status coexist with persistent challenges, including suboptimal breastfeeding practices, declining vitamin A supplementation, and pandemic-related healthcare disruptions, necessitating reinforced health systems and targeted interventions to attain national and SDGs targets.
ConclusionStrengthening nutritional and health services in high-burden areas could improve outcomes in East Java and offer a replicable framework for addressing stunting and malnutrition globally.
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Sweet Taste Preference, Sugar-Sweetened Beverage (SSB) Consumption, and Obesity in Elementary School Children
More LessAuthors: Sheila Amara Putri, Yasmin Halim Bahasuan, Farapti Farapti, Sri Sumarmi and Tonny SundjayaIntroductionChildhood obesity results from an imbalance between energy intake and expenditure, often exacerbated by high consumption of energy-dense foods and sugary beverages. This study aimed to examine the relationship between sweet taste preference, sugar-sweetened beverage (SSB) consumption, and obesity among elementary school children in Indonesia, particularly within the structured environment of a full-day school.
MethodsA cross-sectional study design was used among 129 students from Muhammadiyah 4 Surabaya Elementary School as participants. Data were collected through anthropometric measurements, 24-hour food records, SQ-FFQ questionnaires, PAQ-C activity questionnaires, and Rank-Rating taste tests. Chi-square tests were used for statistical analysis.
ResultsSweet taste preference (p = 0.366), taste sensitivity (p = 0.773), total energy intake (p = 0.266), and school-time energy intake (p = 0.397) were not significantly associated with obesity. However, SSB energy intake (p = 0.046) and total sugar intake (p = 0.001) were positively correlated with the incidence of obesity.
DiscussionThe findings indicate that while sweet taste preference alone may not predict obesity, excessive sugar consumption—particularly from SSBs—plays a major role. This suggests that the type and source of energy, rather than quantity alone, are more impactful.
ConclusionSSB and sugar intake are significantly associated with childhood obesity. Interventions focusing on reducing sugary drink consumption, improving dietary habits, and increasing physical activity are essential. A multilevel approach involving schools, families, and policy is needed to address the growing prevalence of childhood obesity in Indonesia.
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Volumes & issues
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Volume 21 (2025)
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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