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2000
Volume 21, Issue 6
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Hydatid cyst fluid (HCF) is a complex biological substance primarily composed of water, proteins, lipids, carbohydrates, salts, enzymes, hormones, growth factors, immune modulators, and other bioactive molecules. Within HCF, antigens such as antigen B (AgB) and antigen 5 family members (Ag5) have been identified. These antigens have been found to possess the ability to hinder the progression of cancer. Although the exact mechanisms by which these components inhibit cancer progression are not fully understood; it is believed that they may impact various signaling pathways involved in cell proliferation, survival, angiogenesis, and metastasis. In vitro studies have demonstrated that treatment with HCF or specific antigens can impede cell growth, induce apoptosis, and suppress the migration of cancer cells. Animal model studies have also shown significant inhibition of tumor growth, reduction in angiogenesis, and suppression of metastasis. Although limited, clinical studies have displayed promising outcomes, including improved overall survival and reduced recurrence rates among breast cancer patients who received AgB immunotherapy alongside standard treatment. This study attempts to offer a thorough synopsis of research exploring the possible anti-cancer capabilities of HCF and related HFAs.

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2024-08-12
2025-12-06

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References

  1. SchmittF.C. BubendorfL. CanberkS. ChandraA. CreeI.A. EngelsM. HiroshimaK. JainD. KholováI. LayfieldL. MehrotraR. MichaelC.W. OsamuraR. PitmanM.B. Roy-ChowdhuriS. SatohY. VanderLaanP. ZakowskiM.F. FieldA.S. The World Health organization reporting system for lung cytopathology.Acta Cytol.2023671809110.1159/00052758036509066
     [Google Scholar]
  2. MehrotraR. YadavK. Breast cancer in India: Present scenario and the challenges ahead.World J. Clin. Oncol.202213320921810.5306/wjco.v13.i3.20935433294
     [Google Scholar]
  3. AsouliA. SadrS. MohebalianH. BorjiH. Anti-Tumor Effect of Protoscolex Hydatid Cyst Somatic Antigen on Inhibition Cell Growth of K562.Acta Parasitol.202368238539210.1007/s11686‑023‑00680‑336991291
     [Google Scholar]
  4. ShakibapourM. KefayatA. Reza MofidM. ShojaieB. MohamadiF. Maryam SharafiS. MahmoudzadehM. Yousofi DaraniH. Anti-cancer immunoprotective effects of immunization with hydatid cyst wall antigens in a non-immunogenic and metastatic triple-negative murine mammary carcinoma model.Int. Immunopharmacol.20219910795510.1016/j.intimp.2021.10795534247052
     [Google Scholar]
  5. MotavallihaghiS. TanzadehpanahH. Soleimani AslS. ShojaeianA. YousefimashoufM. BaratiN. In vitro anticancer activity of hydatid cyst fluid on colon cancer cell line (C26).Egypt. J. Med. Hum. Genet.20232411510.1186/s43042‑023‑00394‑1
     [Google Scholar]
  6. Castillo-NeyraR. Scoping review protocol on control strategies for Echinococcus Granulosus.OSF202311410.31219/osf.io/vjcmr
     [Google Scholar]
  7. ShahbaziA.E. SaidijamM. MaghsoodA.H. MatiniM. Motavali HaghiM. FallahM. Genotyping of fresh and Parafinized human hydatid cysts using nad1 and cox1 genes in Hamadan Province, west of Iran.Iran. J. Parasitol.202015225926510.18502/ijpa.v15i2.330932595717
     [Google Scholar]
  8. DavoodiL. Seroprevalence of human hydatidosis and survey of risk factors in rural areas of Qaemshahr, Iran 2019.J. Mazandaran Univ. Med. Sci.202030190139145
     [Google Scholar]
  9. CasaravillaC. PittiniÁ. RückerlD. SeoaneP.I. JenkinsS.J. MacDonaldA.S. FerreiraA.M. AllenJ.E. DíazÁ. Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus.Infect. Immun.20148283164317610.1128/IAI.01959‑1424842926
     [Google Scholar]
  10. Yousofi DaraniH. DaneshpourS. KefayatA.H. MofidM.R. Rostami RadS. Effect of hydatid cyst fluid antigens on induction of apoptosis on breast cancer cells.Adv. Biomed. Res.2019812710.4103/abr.abr_220_1831123670
     [Google Scholar]
  11. HassanS. MeenatchiR. PachilluK. BansalS. BrindangnanamP. ArockiarajJ. KiranG.S. SelvinJ. Identification and characterization of the novel bioactive compounds from microalgae and cyanobacteria for pharmaceutical and nutraceutical applications.J. Basic Microbiol.2022629999102910.1002/jobm.20210047735014044
     [Google Scholar]
  12. BaratiN. Anticancer Activity of Antigen B from hydatid cyst fluid of Echinococcus granulosus on melanoma cancer cell line.Res. Sq.2022202210.21203/rs.3.rs‑1655273/v1
     [Google Scholar]
  13. KananiA.N. SenjaliyaS.B. RajaparaM.M. AeschlimannJ. WesthoffC.M. JoshiS.R. P-Null phenotype due to a rare frame-shift mutation and with Allo-Anti-PP1Pk causing a severe hemolytic transfusion reaction: A case report with clinical management.Transfus. Med. Hemother.202148424024310.1159/00051449934539318
     [Google Scholar]
  14. RezaH.A.M. RrezaG. NastaranB. MousaM. Renal hydatid cyst; a rare infectious disease.Oxf. Med. Case Rep.201920193: omz011.10.1093/omcr/omz01130949349
     [Google Scholar]
  15. MotavallihaghiS. Distribution of Human Cystic Echinococcosis and genotypes of hydatid cyst and adult worm of Echinococcus granulosus In Iran: A systematic review and meta-analysis.Int. J. Pharm. Res.2021131
     [Google Scholar]
  16. Vafae EslahiA. GhaffarifarF. Muhammad HassanZ. DalimiA. Anticancer Activity of Hydatid Cyst Fluid along with Antigen B on Tumors Induced by 4T1 Breast Cancer Cell in a BALB/c Mice Model.Iran. J. Parasitol.202217224024910.18502/ijpa.v17i2.954236032740
     [Google Scholar]
  17. GaoX.Y. ZhangG.H. HuangL. Modulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus. OncoTargets Ther.2018111447145610.2147/OTT.S14630029588599
     [Google Scholar]
  18. Yousofi DaraniH. SharafiS.M. Effect of Hydatid Cyst Antigens Polyspecific Antisera on Breast Cancer Cells (4T1) Growth in Cell Culture Medium.Int. J. Environ. Health Eng.20222022December14
     [Google Scholar]
  19. AthbiA. Al-MayahS. KhalafA. Antiparasitic activity of the microalgae Cladophora crispata against the Protoscolices of hydatid cysts compared with albendazole drug.Afr. J. Biotechnol.20141330
     [Google Scholar]
  20. ZhouX. WangW. CuiF. ShiC. MaY. YuY. ZhaoW. ZhaoJ. Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid from patients: isolation, characterization and evaluation of immunomodulatory functions on T cells.Int. J. Parasitol.20194913-141029103710.1016/j.ijpara.2019.08.00331734339
     [Google Scholar]
  21. Zeghir-BouteldjaR. PoloméA. BousbataS. Touil-BoukoffaC. Comparative proteome profiling of hydatid fluid from Algerian patients reveals cyst location-related variation in Echinococcus granulosus.Acta Trop.201717119920610.1016/j.actatropica.2017.03.03428412048
     [Google Scholar]
  22. GottsteinB. SoboslayP. OrtonaE. WangJ. SiracusanoA. VuittonD.Α. Immunology of alveolar and cystic echinococcosis (AE and CE).Adv. Parasitol.20179615410.1016/bs.apar.2016.09.00528212788
     [Google Scholar]
  23. YinJ. LiuC. YuA. YaoJ. ShenY. CaoJ. Pro-angiogenic activity of monocytic-type myeloid-derived suppressor cells from Balb/C mice infected with echinococcus granulosus and the regulatory role of miRNAs.Cell. Physiol. Biochem.20185131207122010.1159/00049549830481745
     [Google Scholar]
  24. YousefiM. AkbariM. hadipourM. DehkordiA.B. FarahbakhshZ. DaraniH.Y. Parasites as potential targets for cancer immunotherapy.J. Cancer Res. Clin. Oncol.2023149108027803810.1007/s00432‑023‑04694‑236949175
     [Google Scholar]
  25. ShoorajM. HajipourE. MahdaviS.A. Immunological Examination of Echinococcus granulosus as a Candidate for Cancer Treatment and Vaccine Development: A Review Study.Tabari Biomedical Student Research Journal202243404810.18502/tbsrj.v4i3.10516
     [Google Scholar]
  26. BerrielE. FreireT. ChialeC. RodríguezE. MorónG. Fernández-GrañaG. CrispoM. BeroisN. OsinagaE. Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1+ cell activation in mice.Cancer Immunol. Immunother.202170123617362710.1007/s00262‑021‑02948‑x33944981
     [Google Scholar]
  27. DaraniH.Y. ShakibapourM. ShojaieB. Immunization with hydatid cyst wall antigens can inhibit breast cancer through changes in serum levels of Th1/Th2 cytokines.Int. J. Prev. Med.202011118910.4103/ijpvm.IJPVM_311_1933815713
     [Google Scholar]
  28. RostamiradS. DaneshpourS. MofidM.R. AndalibA. EskandariyanA. MousaviS. Yousofi DaraniH. Inhibition of mouse colon cancer growth following immunotherapy with a fraction of hydatid cyst fluid.Exp. Parasitol.2023249108501.10.1016/j.exppara.2023.10850136931383
     [Google Scholar]
  29. Rostami radS. DaneshpourS. MofidM. AndalibA. EskandariyanA. Yousofi DaraniH. Effect of hydatid cyst antigens on inhibition of melanoma cancer growth in mouse model.Cell. Mol. Biol.201864121510.14715/cmb/2018.64.12.130301493
     [Google Scholar]
  30. DaraniH.Y. DaneshpourS. RostamiradS. KefayatA. MofidM.R. SafaviA. Identifying the most effective hydatid cyst fluid fraction for anticancer vaccination of 4T1 breast tumor-bearing mice.Int. J. Prev. Med.201910114310.4103/ijpvm.IJPVM_508_1831516684
     [Google Scholar]
  31. StamatakosM. SargediC. StefanakiC. SafioleasC. MatthaiopoulouI. SafioleasM. Anthelminthic treatment: An adjuvant therapeutic strategy against Echinococcus granulosus.Parasitol. Int.200958211512010.1016/j.parint.2009.01.00219272345
     [Google Scholar]
  32. HuangD.Q. MathurinP. Cortez-PintoH. LoombaR. Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.Nat. Rev. Gastroenterol. Hepatol.2023201374910.1038/s41575‑022‑00688‑636258033
     [Google Scholar]
  33. KozakiewiczP. Grzybowska-SzatkowskaL. Application of molecular targeted therapies in the treatment of head and neck squamous cell carcinoma (Review).Oncol. Lett.20181557497750510.3892/ol.2018.830029725456
     [Google Scholar]
  34. PiccoliL. Serum cytokine profile by ELISA in patients with echinococcal cysts of the liver: A stage-specific approach to assess their biological activity.Clin Dev Immunol.2012201248393510.1155/2012/483935
     [Google Scholar]
  35. NiL. LuJ. Interferon gamma in cancer immunotherapy.Cancer Med.2018794509451610.1002/cam4.170030039553
     [Google Scholar]
  36. MohammedA.M. HamzaD.M. MohammedS.N. The Protective Role of Hydatid Cyst against Colorectal Cancers.Indian J. Public Health Res. Dev.201910133210.5958/0976‑5506.2019.00065.2
     [Google Scholar]
  37. TamarozziF. MaricontiM. NeumayrA. BrunettiE. The intermediate host immune response in cystic echinococcosis.Parasite Immunol.201638317018110.1111/pim.1230126683283
     [Google Scholar]
  38. StefaniC. MiricescuD. Stanescu-SpinuI.I. NicaR.I. GreabuM. TotanA.R. JingaM. Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?Int. J. Mol. Sci.202122191026010.3390/ijms22191026034638601
     [Google Scholar]
  39. HajizadehM. JabbariA. SpotinA. HejazianS.S. Mikaeili GalehT. HassanniaH. SahlolbeiM. PaghehA.S. AhmadpourE. Modulatory Effects of Hydatid Cyst Fluid on a Mouse Model of Experimental Autoimmune Encephalomyelitis.Vet. Sci.20241113410.3390/vetsci1101003438250940
     [Google Scholar]
  40. BaoJ. QiW. SunC. TianM. JiaoH. GuoG. GuoB. RenY. ZhengH. WangY. YanM. ZhangZ. McManusD.P. LiJ. ZhangW. Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization.Parasit. Vectors202215139110.1186/s13071‑022‑05498‑y36289514
     [Google Scholar]
  41. GundogduS.B. SaylamB. TezM. Cyst hydatid and cancer: the myth continues.Clinical Chemistry and Laboratory Medicine (CCLM)2017557e150e15110.1515/cclm‑2016‑062627815959
     [Google Scholar]
/content/journals/cctr/10.2174/0115733947299692240801081928
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Investigating the Inhibitory Effects of Hydatid Cyst Fluid and its Antigens on Cancer Progression; A Review
Curr Cancer Ther Rev 21, 783 (2025); https://doi.org/10.2174/0115733947299692240801081928
/content/journals/cctr/10.2174/0115733947299692240801081928
/content/journals/cctr/10.2174/0115733947299692240801081928
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  • Article Type:     Review Article
Keyword(s): angiogenesis; antigens; apoptosis; bioactive molecules; cancer; cancer inhibition; Hydatid cyst fluid

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