Current Bioactive Compounds - Volume 21, Issue 5, 2025

Heterocyclic compounds that incorporate nitrogen and sulfur, particularly those within the thiazole family, have garnered significant attention due to their versatile synthetic properties. This interest arises from their abundance of biologically active natural products and their effectiveness as potent agrochemicals and pharmaceuticals. Among these, the thiazolidin-2,4-dione (TZD) motif plays a pivotal role in the biological funct Read More

IntroductionNon-optimized extraction conditions can lead to loss, degradation, and modification of biomolecules. In this study, we investigated the influence of various factors on the extraction yield and antioxidant activity of total carotenoids from orange coral Astroides calycularis.Materials and MethodsTotal carotenoid yields were compared using eleven different solvent systems, with acetone demonstrating the highest extr Read More

AimThe present study aimed to explore the therapeutic efficacy of an ethanolic extract of Malvaviscus arboreus Dil.Ex.cav against HFD-induced hyperlipidemia in experimental rats.BackgroundDietary alterations influence normal metabolic function and provide significant risks for cardiovascular disease and oxidative stress. The likelihood of dyslipidemia is related to the intake of HFD and is associated with increase Read More

Alzheimer's disease (AD) stands as a pressing global health challenge with limited therapeutic options. In pursuit of alternative interventions, this review critically examines the potential of phytoconstituents in alleviating AD-related cognitive impairments through a comprehensive analysis of preclinical studies. The diverse and intricate pathogenesis of AD calls for multifaceted approaches, and phytoconstituents present a pro Read More

BackgroundAlthough several specialized methods for treating various cancers have been developed, clinical outcomes for patients with colon cancer have shown unfavorable effects in addition to chemotherapeutic drug resistance. Therefore, finding medicinal substances with minimal to no side effects is crucial in the fight against cancer. Further, this study underscores the significance of 2-phenylindolizine acetamide due Read More

IntroductionNature is full of surprises; it gives us problems along with solutions, but the only condition is that it needs to be explored. The ability of endophytes to tackle pathogens is one such example that falls within the context of the current work. In the current study, we have assessed the antifungal potential of endophytic bacterial metabolites of medicinal importance through in-vitro and in-silico studies.Materials and Meth Read More

The multifaceted nature of Schiff bases and their metal complexes has garnered significant attention in the realm of coordination chemistry. Schiff bases are flexible ligands that have been frequently employed to form metal complexes via the nitrogen and oxygen atoms. This unique interaction imparts distinctive properties to the resulting complexes, rendering them valuable in various fields in catalysis, materials research, and Read More

IntroductionScutellaria baicalensis Georgi, a plant with therapeutic properties, has been extensively utilized in China for centuries. The extract derived from its roots is commonly referred to as Huang-Qin.Materials and MethodsThe informative data were gathered from many electronic databases, including Scopus, Science Direct, PubMed, and Web of Science. The study criteria for selection included analyzing scientific Read More

ObjectiveThis work aims to evaluate the combined anti-diabetic effects of metformin and catechin in vitro and in silico.MethodsIn vitro, anti-diabetic potentials of (α-amylase and α-glucosidase) catechin, metformin, and a combination of catechin and metformin were studied at different concentrations using acarbose as standard. An in silico study determined their binding interactions with α-amylase (PDB ID: 1hvx) and α- Read More

Casticin is a flavonoid that is derived from the Vitex species. Multiple studies have investigated the anticancer properties of casticin against many types of cancer, such as bladder cancer, breast cancer, oral cancer, lung cancer, and leukemia. Research has shown the ability of casticin to inhibit cell growth and induce programmed cell death. The chemical exhibits efficacy against numerous cancer cell lines through various molec Read More

ObjectiveThis review study examines Jatropha species' phytochemical and biological features, focusing on their secondary metabolites and biological activities. By integrating current information, the paper aims to support future research.MethodsAn extensive PubMed, Scopus, and Web of Science search was conducted using “Jatropha,” “phytochemicals,” and “biological activity” phrases. Peer-reviewed and relevant pap Read More

BackgroundInflammation, a crucial defense mechanism of the immune system, seeks to safeguard and restore tissue equilibrium in response to tissue damage or infection by pathogens. Key indicators of inflammation include redness, discomfort, swelling, warmth, and impaired function. However, unmanaged inflammation can lead to serious health issues.ObjectiveThe aim of this research work is to perform docking studi Read More