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2000
Volume 15, Issue 4
  • ISSN: 2210-3031
  • E-ISSN: 2210-304X

Abstract

In recent times, Ethosome has become a new promising pharmaceutical nano-carrier for the development of innovative dermal and transdermal therapies that help in the treatment of various skin diseases like skin allergies, urticaria, melisma, eczema, melanoma, and other skin disease. Ethosome is a non-invasive, modified phospholipid-based elastic, soft vesicular nano-carrier with high ethanol content. Ethanol in this formulation facilitates rapid penetration of the drug into the skin accelerating cell membrane lipid fluidity. After permeation into the skin, those get fused with the cell membrane lipids and release the loaded drug. BCS III & IV drugs, having low permeability, can be developed with ethosomal systems. Histamine is one of the responsible biogenic factors for itching, skin wheals, allergies, other skin disorders, ., so incorporation of low permeable antihistaminic drugs in ethosome is an emerging prospect in the field of dermatology and cosmetology. Ethosomes reflect positive insights to overcome side effects associated with conventional oral therapy, quick onset of action, and targeted drug delivery to inflamed skin. The concept of ethosome is considered advantageous over liposome to be more penetrable to the skin. Besides the need for further pharmacokinetic and pharmacodynamics studies on ethosome, it seems to significantly hold a great contemplation for the delivery of medicaments in the skin through different pathways.

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2025-04-14
2025-12-08

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References

  1. EdisZ. WangJ. WaqasM.K. IjazM. IjazM. Nanocarriers- mediated drug delivery systems for anticancer agents: An overview and perspectives.Int. J. Nanomedicine2021161313133010.2147/IJN.S28944333628022
     [Google Scholar]
  2. Ruzycka-AyoushM. KowalikP. KowalczykA. BujakP. NowickaA.M. WojewodzkaM. KruszewskiM. GrudzinskiI.P. Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells.Cancer Nanotechnol.202112127
     [Google Scholar]
  3. GeX. WeiM. HeS. YuanW.E. Advances of non-ionic surfactant vesicles (niosomes) and their application in drug delivery.Pharmaceutics20191125510.3390/pharmaceutics1102005530700021
     [Google Scholar]
  4. GuillotA.J. Martínez-NavarreteM. GarriguesT.M. MeleroA. Skin drug delivery using lipid vesicles: A starting guideline for their development.J. Control. Release202335562465410.1016/j.jconrel.2023.02.00636775245
     [Google Scholar]
  5. PatelM PatelJ UpadhyayU. Ethosomes: Versatile vesicular carriers for effective medicinal drug transdermal administration.Int J Drug Dev Res J20221410978
     [Google Scholar]
  6. TouitouE. GodinB. WeissC. Enhanced delivery of drugs into and across the skin by ethosomal carriers.Drug Dev. Res.2000503-440641510.1002/1098‑2299(200007/08)50:3/4<406::AID‑DDR23>3.0.CO;2‑M
     [Google Scholar]
  7. HariharanbS JustincA Topical delivery of drugs using ethosomes: A review.INDIAN DRUGS2019568720
     [Google Scholar]
  8. DasS.K. ChakrabortyS. RoyC. RajabalayaR. MohaiminA.W. KhanamJ. NandaA. DavidS.R. Ethosomes as novel vesicular carrier: An overview of the principle, preparation and its applications.Curr. Drug Deliv.201815679581710.2174/156720181566618011609160429336262
     [Google Scholar]
  9. Paiva-SantosA.C. SilvaA.L. GuerraC. PeixotoD. Pereira-SilvaM. ZeinaliM. Mascarenhas-MeloF. CastroR. VeigaF. Ethosomes as nanocarriers for the development of skin delivery formulations.Pharm. Res.202138694797010.1007/s11095‑021‑03053‑534036520
     [Google Scholar]
  10. GoindiS. DhattB. KaurA. Ethosomes-based topical delivery system of antihistaminic drug for treatment of skin allergies.J. Microencapsul.201431771672410.3109/02652048.2014.91866724963956
     [Google Scholar]
  11. ShuklaK.V. SharmaA. YadavM. Formulation development and evaluation of ethosomal gel of acyclovir for the treatment of herpes zoster.J. Drug Deliv. Ther.201994-A66466810.22270/jddt.v9i4‑A.3548
     [Google Scholar]
  12. GodinB. TouitouE. Erythromycin ethosomal systems: Physicochemical characterization and enhanced antibacterial activity.Curr. Drug Deliv.20052326927510.2174/156720105436793116305429
     [Google Scholar]
  13. ShimJ. KangH.S. ParkW.S. HanS.H. Transdermal delivery of minoxidil with ethanolic liposomes.J. Control. Release20039747748410.1016/S0168‑3659(04)00167‑115212879
     [Google Scholar]
  14. IndoraN KaushikD Design, development and evaluation of ethosomal gel of fluconazole for topical fungal infection.Int. J. Eng. Sci. Invention Res. Dev.201518280306
     [Google Scholar]
  15. BendasE.R. TadrosM.I. Enhanced transdermal delivery of salbutamol sulfate via ethosomes.AAPS PharmSciTech20078421310.1208/pt080410718181528
     [Google Scholar]
  16. BijuS. TalegaonkarS. MishraP. KharR. Vesicular systems: An overview.Indian J. Pharm. Sci.2006682
     [Google Scholar]
  17. VermaP. PathakK. Therapeutic and cosmeceutical potential of ethosomes: An overview.J. Adv. Pharm. Technol. Res.20101327428210.4103/0110‑5558.7241522247858
     [Google Scholar]
  18. BhatiaS. SinghV. SinghM. SinghD. SinghT. PiplaniM. SinghR. Ethosomes: Novel vesicular carriers for effective transdermal delivery of natural therapeutics.Lett. Drug Des. Discov.202421466568310.2174/1570180820666221226153523
     [Google Scholar]
  19. YurtseverA.G. EkmekciogluA. MuftuogluM. GüngörS. ErdalM.S. Formulation development and evaluation of fluvastatin loaded transethosomes: Characterization, stability, in vitro dermal penetration, cytotoxicity and antipsoriatic activity studies.J. Drug Deliv. Sci. Technol.20249110523410.1016/j.jddst.2023.105234
     [Google Scholar]
  20. AgrawalA. JoshiA. BhattacharyaS. Recent excavation of nanoethosomes in current drug delivery.Curr. Drug Deliv.202421216818310.2174/156720182066622122010301336545741
     [Google Scholar]
  21. FerraraF. BondiA. PulaW. ContadoC. BaldisserottoA. ManfrediniS. BoldriniP. SguizzatoM. MontesiL. BenedusiM. ValacchiG. EspositoE. Ethosomes for curcumin and piperine cutaneous delivery to prevent environmental-stressor-induced skin damage.Antioxidants20241319110.3390/antiox1301009138247515
     [Google Scholar]
  22. El-MahdyM.M. HassanA.S. El-BadryM. El-GindyG.E. Performance of curcumin in nanosized carriers niosomes and ethosomes as potential anti-inflammatory delivery system for topical application.Bull. Pharm. Sci. Assiut.2020431105122
     [Google Scholar]
  23. KumarK.P. RadhikaP.R. SivakumarT. Ethosomes-a priority in transdermal drug delivery. Int. J. Adv. Pharm. Sci.201012
     [Google Scholar]
  24. ChandraA. AggarwalG. ManchandaS. NarulaA. Development of topical gel of methotrexate incorporated ethosomes and salicylic acid for the treatment of psoriasis.Pharm. Nanotechnol.20197536237410.2174/221173850766619090612364331490769
     [Google Scholar]
  25. LazzariniR. MendonçaR.F. HafnerM.F.S. Allergic contact dermatitis to shoes: Contribution of a specific series to the diagnosis.An. Bras. Dermatol.201893569670010.1590/abd1806‑4841.2018737030156619
     [Google Scholar]
  26. GodinB. TouitouE. Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier.J. Control. Release2004942-336537910.1016/j.jconrel.2003.10.01414744487
     [Google Scholar]
  27. TouitouE. GodinB. DayanN. WeissC. PiliponskyA. Levi-SchafferF. Intracellular delivery mediated by an ethosomal carrier.Biomaterials200122223053305910.1016/S0142‑9612(01)00052‑711575480
     [Google Scholar]
  28. BhalariaMK NaikS MisraAN Ethosomes: A novel delivery system for antifungal drugs in the treatment of topical fungal diseases.Indian J. Exp. Biol.2009475368375
     [Google Scholar]
  29. PatrekarP.V. InamdarS.J. MaliS.S. MujibM.T. AhirA.A. HosmaniA.H. Ethosomes as novel drug delivery system: A review.Pharma Innov.201549, Part A10
     [Google Scholar]
  30. Jun-BoT. Zhuang-QunY. Xi-JingH. YingX. YongS. ZheX. TaoC. Effect of ethosomal minoxidil on dermal delivery and hair cycle of C57BL/6 mice.J. Dermatol. Sci.200745213513710.1016/j.jdermsci.2006.09.00717074469
     [Google Scholar]
  31. BrockowK. MørtzC.G. Global atlas of skin allergy.2019Available from: https://eaaci-cdn-vod02-prod.azureedge.net/KnowledgeHub/education/books/Global%20Atlas%20of%20Skin%20Allergy.pdf
  32. SalahS. TaiebC. DemessantA.L. HaftekM. Prevalence of skin reactions and self-reported allergies in 5 countries with their social impact measured through quality of life impairment.Int. J. Environ. Res. Public Health2021189450110.3390/ijerph1809450133922720
     [Google Scholar]
  33. NewsonR.B. van ReeR. ForsbergB. JansonC. LötvallJ. DahlénS.E. ToskalaE.M. BælumJ. BrożekG.M. KasperL. KowalskiM.L. HowarthP.H. FokkensW.J. BachertC. KeilT. KrämerU. BislimovskaJ. GjomarkajM. LoureiroC. BurneyP.G.J. JarvisD. Geographical variation in the prevalence of sensitization to common aeroallergens in adults: The GA 2 LEN survey.Allergy201469564365110.1111/all.1239724654915
     [Google Scholar]
  34. FarazK. SeelyM. MaranoA.L. The role of the environment in allergic skin disease.Curr. Allergy Asthma Rep.202424632333010.1007/s11882‑024‑01147‑938733510
     [Google Scholar]
  35. SassevilleD. Occupational contact dermatitis.Allergy Asthma Clin. Immunol.200842596510.1186/1710‑1492‑4‑2‑5920525126
     [Google Scholar]
  36. PortelliM.A. HodgeE. SayersI. Genetic risk factors for the development of allergic disease identified by genome-wide association.Clin. Exp. Allergy2015451213110.1111/cea.1232724766371
     [Google Scholar]
  37. JainS. TiwaryA.K. SapraB. JainN.K. Formulation and evaluation of ethosomes for transdermal delivery of lamivudine.AAPS PharmSciTech20078424910.1208/pt080411118181532
     [Google Scholar]
  38. FangY.P. TsaiY.H. WuP.C. HuangY.B. Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.Int. J. Pharm.20083561-214415210.1016/j.ijpharm.2008.01.02018325699
     [Google Scholar]
  39. FangJ.Y. HwangT.L. LeuY.L. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels.Int. J. Pharm.2003250231332510.1016/S0378‑5173(02)00540‑912527159
     [Google Scholar]
  40. JainS. PatelN. MadanP. LinS. Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route.Pharm. Dev. Technol.201520447348910.3109/10837450.2014.88293924490793
     [Google Scholar]
  41. MistryA. RavikumarP. Development and evaluation of azelaic acid based ethosomes for topical delivery for the treatment of acne.Indian J. Pharm. Educ. Res.2016503sS232S24310.5530/ijper.50.3.34
     [Google Scholar]
  42. LiuJ. HuG. Advances in studies of phospholipids as carriers in skin topical application.J. Nanjing Med. Univ.200721634935310.1016/S1007‑4376(07)60076‑8
     [Google Scholar]
  43. GodinB. TouitouE. RubinsteinE. AthamnaA. AthamnaM. A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: An in vivo study.J. Antimicrob. Chemother.200555698999410.1093/jac/dki12515857943
     [Google Scholar]
  44. VermaD.D. VermaS. BlumeG. FahrA. Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: A skin penetration and confocal laser scanning microscopy study.Eur. J. Pharm. Biopharm.200355327127710.1016/S0939‑6411(03)00021‑312754000
     [Google Scholar]
  45. DaveV. KumarD. LewisS. PaliwalS. Ethosome for enhanced transdermal drug delivery of aceclofenac.Int. J. Drug Deliv.201021819210.5138/ijdd.2010.0975.0215.02016
     [Google Scholar]
  46. SakdisetP. AmnuaikitT. PichayakornW. PinsuwanS. Formulation development of ethosomes containing indomethacin for transdermal delivery.J. Drug Deliv. Sci. Technol.20195276076810.1016/j.jddst.2019.05.048
     [Google Scholar]
  47. SongC.K. BalakrishnanP. ShimC.K. ChungS.J. ChongS. KimD.D. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation.Colloids Surf. B Biointerfaces20129229930410.1016/j.colsurfb.2011.12.00422205066
     [Google Scholar]
  48. AinbinderD. TouitouE. Testosterone ethosomes for enhanced transdermal delivery.Drug Deliv.200512529730310.1080/1071754050017691016188729
     [Google Scholar]
  49. PaolinoD. LucaniaG. MardenteD. AlhaiqueF. FrestaM. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.J. Control. Release20051061-29911010.1016/j.jconrel.2005.04.00715935505
     [Google Scholar]
  50. JainS. UmamaheshwariR.B. BhadraD. JainN.K. Ethosomes: A novel vesicular carrier for enhanced transdermal delivery of an antiHIV agent.Indian J. Pharm. Sci.20046617281
     [Google Scholar]
  51. AbdulbaqiI.M. DarwisY. KhanN.A. AssiR.A. KhanA.A. Ethosomal nanocarriers: The impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials.Int. J. Nanomedicine2016112279230410.2147/IJN.S10501627307730
     [Google Scholar]
  52. de la PresaP. RuedaT. del Puerto MoralesM. ChichónF.J. ArranzR. ValpuestaJ.M. HernandoA. Gold nanoparticles generated in ethosome bilayers, as revealed by cryo-electron-tomography.J. Phys. Chem. B2009113103051305710.1021/jp808650e19708264
     [Google Scholar]
  53. SaudagarR.B. SamuelS. Ethosomes: Novel noninvasive carrier for transdermal drug delivery.Asian J. Pharm. Technol.20166213513810.5958/2231‑5713.2016.00019.2
     [Google Scholar]
  54. GodinB TouitouE. Ethosomes: New prospects in transdermal delivery.Crit. Rev. Ther. Drug Carrier Syst.20032016310210.1615/CritRevTherDrugCarrierSyst.v20.i1.20
     [Google Scholar]
  55. DhakarR.C. Formulation development and evaluation of ethosome of stavudine.Indian J.Pharm. Educ. Res202144110210810.2139/ssrn.3774625
     [Google Scholar]
  56. ManosroiA. JantrawutP. KhositsuntiwongN. ManosroiW. ManosroiJ. Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications.Chiang Mai J. Sci.2009362168178
     [Google Scholar]
  57. EspositoE. MenegattiE. CortesiR. Ethosomes and liposomes as topical vehicles for azelaic acid: A preformulation study.Int. J. Cosmet. Sci.200426527027110.1111/j.1467‑2494.2004.00233_2.x15264053
     [Google Scholar]
  58. PathanI.B. JawareB.P. ShelkeS. AmbekarW. Curcumin loaded ethosomes for transdermal application: Formulation, optimization, in-vitro and in-vivo study.J. Drug Deliv. Sci. Technol.201844495710.1016/j.jddst.2017.11.005
     [Google Scholar]
  59. AhadA. AqilM. KohliK. SultanaY. MujeebM. Enhanced transdermal delivery of an anti-hypertensive agent via nanoethosomes: Statistical optimization, characterization and pharmacokinetic assessment.Int. J. Pharm.20134431-2263810.1016/j.ijpharm.2013.01.01123313344
     [Google Scholar]
  60. NasrA.M. MoftahF. AbourehabM.A.S. GadS. Design, formulation, and characterization of valsartan nanoethosomes for improving their bioavailability.Pharmaceutics20221411226810.3390/pharmaceutics1411226836365087
     [Google Scholar]
  61. PaliwalS. TilakA. SharmaJ. DaveV. SharmaS. YadavR. PatelS. VermaK. TakK. Flurbiprofen loaded ethosomes - Transdermal delivery of anti-inflammatory effect in rat model.Lipids Health Dis.201918113310.1186/s12944‑019‑1064‑x30611256
     [Google Scholar]
  62. ChauhanN. VasavaP. KhanS.L. SiddiquiF.A. IslamF. ChopraH. EmranT.B. Ethosomes: A novel drug carrier.Ann. Med. Surg.20228210459510.1016/j.amsu.2022.10459536124209
     [Google Scholar]
  63. FiddianA.P. YeoJ.M. StubbingsR. DeanD. Successful treatment of herpes labialis with topical acyclovir.BMJ198328663791699170110.1136/bmj.286.6379.16996405939
     [Google Scholar]
  64. SpruanceSL The natural history of recurrent oral-facial herpes simplex virus infection.Semin. Dermatol.1992113200206
     [Google Scholar]
  65. KimD.D. ChienY.W. Simultaneous skin permeation of dideoxynucleoside-type anti-HIV drugs.J. Control. Release1996401-2677610.1016/0168‑3659(95)00172‑7
     [Google Scholar]
  66. FuY. HsiehT. GuoJ. KunickiJ. LeeM.Y.W.T. DarzynkiewiczZ. WuJ.M. Licochalcone-A, A novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.Biochem. Biophys. Res. Commun.2004322126327010.1016/j.bbrc.2004.07.09415313200
     [Google Scholar]
  67. VermaD.D. FahrA. Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin A.J. Control. Release2004971556610.1016/j.jconrel.2004.02.02815147804
     [Google Scholar]
  68. KumarR. AslamM.D. TripathiA. PrasadD. ChaudharyV. JainV. MishraS.K. SinghR. Ethosomes: Novel vesicular carriers in transdermal drug delivery.J. Glob. Pharma Technol.20102617
     [Google Scholar]
  69. Abu-HuwaijR. ZidanA.N. Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review.J. Cosmet. Dermatol.2024231172610.1111/jocd.1589537393573
     [Google Scholar]
  70. EspositoE. CalderanL. GalvanA. CappellozzaE. DrechslerM. MarianiP. PepeA. SguizzatoM. VigatoE. Dalla PozzaE. MalatestaM. ex-vivo evaluation of ethosomes and transethosomes applied on human skin: A comparative study.Int. J. Mol. Sci.202223231511210.3390/ijms23231511236499432
     [Google Scholar]
  71. AkhtarN. AkhtarN. MenaaF. AlharbiW. AlaryaniF. AlqahtaniA. AhmadF. Fabrication of ethosomes containing tocopherol acetate to enhance transdermal permeation: in vitro and ex-vivo characterizations.Gels20228633510.3390/gels806033535735679
     [Google Scholar]
  72. KumarB. SahooP.K. Potential of ethosomes for enhanced transdermal drug delivery in skin diseases.Nanomed. J.202294
     [Google Scholar]
  73. PayizilaZ. TengF. HuangX. LiuW. WuT. SunQ. ZhaoS. Efficient fabrication of self-assembled polylactic acid colloidosomes for pesticide encapsulation.ACS Omega202493acsomega.3c0780210.1021/acsomega.3c0780238284048
     [Google Scholar]
  74. KumarS. KumarA. KumarN. SinghP. SinghT.U. SinghB.R. GuptaP.K. ThakurV.K. in vivo therapeutic efficacy of Curcuma longa extract loaded ethosomes on wound healing.Vet. Res. Commun.20224641033104910.1007/s11259‑022‑09952‑135796857
     [Google Scholar]
  75. AjikumarA. DharanS.S. ChandraS.M. SomanM. MathewL.T. Formulation and evaluation of ethosomal gel containing clarithromycin for the treatment of acne vulgaris.J. Pharm. Sci. Res.2022147825833
     [Google Scholar]
  76. RathoreA.R. KhambeteH. JainS. Preparation and characterization of repaglinide loaded ethosomal gel for the treatment of NIDDM.Int. J. Pharm. Biol. Arch.201342385390
     [Google Scholar]
  77. ShahwalV.K. SamnaniA. DubeyB.K. BhowmickM. Ethosomes: An overview.Int. J. Biol. Adv. Res.20112515916610.7439/ijbar.v2i5.31
     [Google Scholar]
  78. BasuB. DuttaA. PariharA. PrajapatiB. MajumderR. Ethosomes: A Lipid-Based Drug Delivery System. InLipid-Based Drug Delivery Systems.Jenny Stanford Publishing2024223297
     [Google Scholar]
  79. AkhtarN. MenaaF. AkhtarN. javedN. SethiA. KhanM.S. Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin.J. Cosmet. Dermatol.20242331015102810.1111/jocd.1605438268219
     [Google Scholar]
  80. UpadhyayN. MandalS. BhatiaL. ShaileshS. ChauhanP. A review on ethosomes: An emerging approach for drug delivery through the skin.Res. Rev. J. Sci. Technol.2011371924
     [Google Scholar]
  81. SivakranthM. Ethosomes: A novel vesicular drug delivery system.Int. J. Adv. Pharm. Res.2012211627
     [Google Scholar]
  82. KadhimZM SaeedAM SabryHS HammoodiID Ethosomes as pharmaceutical novel drug delivery techniquescience2022253
     [Google Scholar]
  83. SguizzatoM. MarianiP. SpinozziF. BenedusiM. CervellatiF. CortesiR. DrechslerM. PrieuxR. ValacchiG. EspositoE. Ethosomes for coenzyme Q10 cutaneous administration: From design to 3D skin tissue evaluation.Antioxidants20209648510.3390/antiox906048532503293
     [Google Scholar]
  84. VögtleF. GestermannS. HesseR. SchwierzH. WindischB. Functional dendrimers.Prog. Polym. Sci.2000257987104110.1016/S0079‑6700(00)00017‑4
     [Google Scholar]
  85. Laz BendasE.R. TadrosM.I. Enhanced transdermal delivery of sulbutamol sulfate via ethosomes.AAPS PharmSciTech2007817
     [Google Scholar]
  86. LiuX. LiuH. LiuJ. HeZ. DingC. HuangG. ZhouW. ZhouL. Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo .Int. J. Nanomedicine2011624124710.2147/IJN.S1604421499422
     [Google Scholar]
  87. ParkS.N. LeeH.J. GuH.A. Enhanced skin delivery and characterization of rutin-loaded ethosomes.Korean J. Chem. Eng.201431348548910.1007/s11814‑013‑0232‑3
     [Google Scholar]
  88. MaheshwariR.G.S. TekadeR.K. SharmaP.A. DarwhekarG. TyagiA. PatelR.P. JainD.K. Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment.Saudi Pharm. J.201220216117010.1016/j.jsps.2011.10.00123960788
     [Google Scholar]
  89. MishraD MishraPK DubeyV NaharM DabadghaoS JainNK Systemic and mucosal immune response induced by transcutaneous immunization using Hepatitis B surface antigen-loaded modified liposomes.Eur. J. Pharm. Sci.2008334-5424433
     [Google Scholar]
  90. MaestrelliF. CapassoG. González-RodríguezM.L. RabascoA.M. GhelardiniC. MuraP. Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes.J. Liposome Res.200919425326010.3109/0898210090278840819863160
     [Google Scholar]
  91. ZhouY. WeiY. LiuH. ZhangG. WuX. Preparation and in vitro evaluation of ethosomal total alkaloids of Sophora alopecuroides loaded by a transmembrane pH-gradient method.AAPS PharmSciTech20101131350135810.1208/s12249‑010‑9509‑620740333
     [Google Scholar]
  92. SoltanipoorM. KezicS. SluiterJ.K. de WitF. BosmaA.L. van AsperenR. RustemeyerT. Effectiveness of a skin care programme for the prevention of contact dermatitis in healthcare workers (the Healthy Hands Project): A single-centre, cluster randomized controlled trial.Contact Dermat.201980636537310.1111/cod.1321430652317
     [Google Scholar]
  93. ChettyDJ ChienYW Novel methods of insulin delivery: An update.Crit. Rev. Ther. Drug Carrier Syst.199815662967010.1615/CritRevTherDrugCarrierSyst.v15.i6.30
     [Google Scholar]
  94. RamtekeS. BarupalA.K. GuptaV. Preparation and characterization of ethosomes for topical delivery of aceclofenac.Indian J. Pharm. Sci.201072558258610.4103/0250‑474X.7852421694989
     [Google Scholar]
  95. NasrM. MansourS. MortadaN.D. ElshamyA.A. Vesicular aceclofenac systems: A comparative study between liposomes and niosomes.J. Microencapsul.200825749951210.1080/0265204080205541118608811
     [Google Scholar]
  96. GuptaP.N. MishraV. RawatA. DubeyP. MahorS. JainS. ChatterjiD.P. VyasS.P. Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: A comparative study.Int. J. Pharm.20052931-2738210.1016/j.ijpharm.2004.12.02215778046
     [Google Scholar]
  97. TouitouE. DayanN. BergelsonL. GodinB. EliazM. Ethosomes — Novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties.J. Control. Release200065340341810.1016/S0168‑3659(99)00222‑910699298
     [Google Scholar]
  98. BasuA HalderM DasA DasR BhattacharjeeC. Nanomaterials in drug delivery: Application of polysaccharides and protein-based nanomaterials in modern drug deliveryBiogenic Nanomaterials for Environmental Sustainability: Principles, Practices, and Opportunities. Environmental Science and Engineering.SpringerCham2024293317
     [Google Scholar]
  99. KarpeS. GuptaK. VyasG. RanaP. KhanF. KumarR. Virosome: A vector in vaccine delivery.BIO Web of Conf.2024860102010.1051/bioconf/20248601020
     [Google Scholar]
  100. SvensonS. TomaliaD.A. Dendrimers in biomedical applications—Reflections on the field.Adv. Drug Deliv. Rev.20126410211510.1016/j.addr.2012.09.03016305813
     [Google Scholar]
  101. BarnesP.J. Pathophysiology of allergic inflammation.Immunol. Rev.20112421315010.1111/j.1600‑065X.2011.01020.x21682737
     [Google Scholar]
  102. ShabreenR. SangeethaS. Ethosomes: A novel drug delivery system and their therapeutic applications-A review.Res. J. Pharm. Technol.20201341972198010.5958/0974‑360X.2020.00355.8
     [Google Scholar]
  103. El-ShenawyA.A. AbdelhafezW.A. IsmailA. KassemA.A. Formulation and characterization of nanosized ethosomal formulations of antigout model drug (febuxostat) prepared by cold method: in vitro/ex-vivo and in vivo assessment.AAPS PharmSciTech20202113110.1208/s12249‑019‑1556‑z31858305
     [Google Scholar]
  104. HamzahM. KassabH. Formulation and characterization of intranasal drug delivery of frovatriptan-loaded binary ethosomes gel for brain targeting.Nanotechnol. Sci. Appl.20241711910.2147/NSA.S44295138249545
     [Google Scholar]
  105. SailajaA.K. MeghanaT. Formulation and evaluation of invasomal and ethosomal gel for curcumin and determination of anti-fungal activity.Curr. Nanomater.202491556910.2174/2405461508666230329122937
     [Google Scholar]
  106. AlfehaidF.S. NairA.B. ShahH. AldhubiabB. ShahJ. MewadaV. JacobS. AttimaradM. Enhanced transdermal delivery of apremilast loaded ethosomes: Optimization, characterization and in vivo evaluation.J. Drug Deliv. Sci. Technol.20249110521110.1016/j.jddst.2023.105211
     [Google Scholar]
  107. JainH. PatelJ. JoshiK. PatelP. UpadhyayU.M. Ethosomes: A novel drug carrier.Int. J. Clin. Pract.2011711421155936
     [Google Scholar]
  108. MengS. ChenZ. YangL. ZhangW. LiuD. GuoJ. GuanY. LiJ. Enhanced transdermal bioavailability of testosterone propionate via surfactant-modified ethosomes.Int. J. Nanomedicine201383051306010.2147/IJN.S4674823990718
     [Google Scholar]
  109. AljohaniA.A. AlanaziM.A. MunahhiL.A. HamroonJ.D. MortagiY. QushawyM. SolimanG.M. Binary ethosomes for the enhanced topical delivery and antifungal efficacy of ketoconazole.OpenNano20231110014510.1016/j.onano.2023.100145
     [Google Scholar]
  110. RichaP. KumarS.D. KumarS.A. Formulation and evaluation of ethosomes of clobetasol propionate.World J. Pharm. Res.2016511831197
     [Google Scholar]
  111. LiG. FanY. FanC. LiX. WangX. LiM. LiuY. Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation.Eur. J. Pharm. Biopharm.2012821495710.1016/j.ejpb.2012.05.01122705640
     [Google Scholar]
  112. Formulation and clinical evaluation of ethosomal and liposomal preparations of anthralin in psoriasis.Patent NCT033484622020
  113. Ethosomal gel bearing Losartan 5% for Keloid treatment.Patent NCT058931082023
  114. HuanbuttaK. RattanachitthawatN. LuangpraditkunK. SriamornsakP. PuriV. SinghI. SangnimT. Development and evaluation of ethosomes loaded with Zingiber zerumbet Linn rhizome extract for antifungal skin infection in deep layer skin.Pharmaceutics20221412276510.3390/pharmaceutics1412276536559259
     [Google Scholar]
  115. MehmoodY. ShahidH. AhmedS. KhursheedA. JamshaidT. JamshaidM. MengistieA.A. DawoudT.M. SiddiqueF. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: Physical characterization, in vitro and ex-vivo studies.Sci. Rep.20241412386610.1038/s41598‑024‑72951‑638167627
     [Google Scholar]
  116. Baicalin ethosome-loaded soluble hyaluronic acid microneedle array and preparation method and application thereofPatent CN113750033B2023
  117. Method of preparing bioactive substance-encapsulated ethosome, ethosome composition, and cosmetic composition including ethosome composition.Patent US11452679B22022
  118. Pharmaceutical composition ethosome, gel, hydrogel paste, patch and preparation methodPatent CN114376975A2022
  119. Tretinoin ethosomes gel and preparation method thereof.Patent CN104983675A2018
  120. Antioxidant nanometer ethosome rose essence and preparation method thereof.Patent CN106880505B2020
  121. Preparation method of galactosylated chitosan modified immune ethosome.Patent CN105726485A2019
  122. Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof.Patent CN103536700A2015
  123. Daptomycin ethosome preparation.Patent CN103006562A2014
  124. Paclitaxel ethosome gel and preparation method thereof.Patent CN102579323A2013
  125. Acyclovir ethosome and preparation method thereof.Patent CN102133183A2012
  126. TütingT. StorkusW.J. FaloL.D.Jr DNA immunization targeting the skin: Molecular control of adaptive immunity.J. Invest. Dermatol.1998111218318810.1046/j.1523‑1747.1998.00261.x9699714
     [Google Scholar]
  127. MusazziU.M. MariniV. CasiraghiA. MinghettiP. Is the European regulatory framework sufficient to assure the safety of citizens using health products containing nanomaterials?Drug Discov. Today201722687088210.1016/j.drudis.2017.01.01628189800
     [Google Scholar]
  128. BragagniM. MenniniN. MaestrelliF. CirriM. MuraP. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib.Drug Deliv.201219735436110.3109/10717544.2012.72447223043648
     [Google Scholar]
/content/journals/ddl/10.2174/0122103031333671250407165403
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Unlocking the Potential of Ethosomes in Dermatological Treatments
Drug Deliv Lett 15, 391 (2025); https://doi.org/10.2174/0122103031333671250407165403
/content/journals/ddl/10.2174/0122103031333671250407165403
/content/journals/ddl/10.2174/0122103031333671250407165403
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  • Article Type:     Review Article
Keyword(s): antibiotics; ethanol; Ethosome; histamine and antihistamines; novel vesicular carrier; penetration enhancer; skin disorders; transdermal drug delivery

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