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image of Advances in the Synthesis and Therapeutic Exploration of Pyrazole/Pyrazoline-Bearing Benzimidazoles: Searching for New Lead Compounds

Abstract

This comprehensive review outlines the multifaceted applications of pyrazolines and benzimidazoles, encompassing their discovery, synthetic methodologies, patent landscape, and clinical trial outcomes, with a focus on pyrazoline-benzimidazole or pyrazole-benzimidazole derivatives. This review highlights the synthesis and biological evaluation of pyrazoline-bearing benzimidazoles obtained through the reaction of benzimidazoles with substituted pyrazolines/pyrazoles. The synthesized compounds demonstrated a broad spectrum of pharmacological activities, including antimicrobial, antibacterial, antitubercular, antimalarial, anthelmintic, antiproliferative, anticancer, antinociceptive, antihistaminic, antiulcer, Research on pyrazoline and benzimidazole derivatives constitutes a dynamic field, expanding the research domain within pharmaceutical chemistry and offering potential therapeutic solutions for various diseases.

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2025-07-11
2025-11-06

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Advances in the Synthesis and Therapeutic Exploration of Pyrazole/Pyrazoline-Bearing Benzimidazoles: Searching for New Lead Compounds
Bentham Science Publishers ; https://doi.org/10.2174/0113852728376996250619071442
/content/journals/coc/10.2174/0113852728376996250619071442
/content/journals/coc/10.2174/0113852728376996250619071442
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  • Article Type:     Review Article
Keywords: pyrazole ; pyrazoline ; anthelmintic ; pyrazoline bearing benzimidazoles ; Benzimidazole ; lead compounds

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