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image of Recent Development of Asymmetric Allylic Alkylation with Organometallic Reagents by Copper-Catalysis

Abstract

Asymmetric catalysis has witnessed remarkable progress in recent decades, due to the importance of chiral compounds, which play a pivotal role in numerous contemporary fields. Catalytic enantioselective C-C bond formation is an efficient method for constructing a variety of chiral molecules. Copper-catalyzed asymmetric allylic alkylation stands out as one of the most effective and appealing approaches within this category. This review comprehensively summarizes representative examples of asymmetric allylic alkylation catalyzed by copper, involving organometallic reagents over the last few decades, and classifies them according to the type of organometallic reagents, such as organomagnesium and organolithium compounds.

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2025-08-13
2025-11-06

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/content/journals/coc/10.2174/0113852728391569250728062701
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Recent Development of Asymmetric Allylic Alkylation with Organometallic Reagents by Copper-Catalysis
Bentham Science Publishers ; https://doi.org/10.2174/0113852728391569250728062701
/content/journals/coc/10.2174/0113852728391569250728062701
/content/journals/coc/10.2174/0113852728391569250728062701
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  • Article Type:     Review Article
Keywords: Grignard reagents ; enantioselectivity ; copper-catalysis ; organolithium reagents ; Asymmetric allylic alkylation ; organometallic reagents

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