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Abstract

Carvacrol is a major active compound present in the essential oils of various aromatic plants. Research strongly indicates that carvacrol holds considerable promise for use in the development of new pharmaceutical drugs and dietary supplements. Due to its broad spectrum of bioactive properties, carvacrol shows potential therapeutic applications for several complex and challenging brain-related disorders. Its actions are multifaceted; it mitigates neuroinflammation and exerts antioxidant properties as well as other neuroprotective effects that shield neural structures from degeneration. Additionally, carvacrol influences important neural systems, including the cholinergic and dopaminergic pathways, helping to regulate neurotransmitter levels and activity in ways that could mitigate neurological symptoms. Furthermore, its anti-apoptotic effects suggest that it can help prevent programmed cell death, a common factor in neurodegenerative diseases. Collectively, these biological properties make carvacrol an attractive option for use as an adjunctive or supportive therapy in managing a range of brain illnesses, including epilepsy, anxiety, depression, stroke, Parkinson's disease, and Alzheimer’s disease. This study presents an extensive review of as well as research studies on carvacrol’s protective effects across different brain disorders. By examining these studies, this review offers a comprehensive and up-to-date assessment of the biological activities and molecular mechanisms of carvacrol, emphasizing its potential role in therapeutic strategies aimed at supporting brain health and treating complex neurological conditions.

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/content/journals/cnsamc/10.2174/0118715249387846251006093402
2025-11-03
2026-03-04
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References

  1. Ma R. Kutchy N.A. Chen L. Meigs D.D. Hu G. Primary cilia and ciliary signaling pathways in aging and age-related brain disorders. Neurobiol. Dis. 2022 163 105607 10.1016/j.nbd.2021.105607 34979259
    [Google Scholar]
  2. le Feber J. In vitro models of brain disorders. Adv. Neurobiol. 2019 22 19 49 10.1007/978‑3‑030‑11135‑9_2 31073931
    [Google Scholar]
  3. Mishra A. Mishra P.S. Bandopadhyay R. Khurana N. Angelopoulou E. Paudel Y.N. Piperi C. Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders. Molecules 2021 26 21 6456 10.3390/molecules26216456 34770864
    [Google Scholar]
  4. Goyal A. Singh G. Verma A. A comprehensive review on therapeutic potential of chrysin in brain related disorders. CNS Neurol. Disord. Drug Targets 2023 22 6 789 800 10.2174/1871527321666220602111935 35657041
    [Google Scholar]
  5. Li Q. Ding X. Chang Z. Fan X. Pan J. Yang Y. Li X. Jiang W. Fan K. Metal-organic framework based nanozyme system for NLRP3 inflammasome-mediated neuroinflammatory regulation in Parkinson’s disease. Adv. Healthc. Mater. 2024 13 10 2303454 10.1002/adhm.202303454 38031989
    [Google Scholar]
  6. Mir R.H. Shah A.J. Mohi-Ud-Din R. Pottoo F.H. Dar M.A. Jachak S.M. Masoodi M.H. Natural Anti-inflammatory compounds as drug candidates in Alzheimer’s disease. Curr. Med. Chem. 2021 28 23 4799 4825 10.2174/1875533XMTA4aNzUBx 32744957
    [Google Scholar]
  7. Raikwar S.P. Kikkeri N.S. Sakuru R. Saeed D. Zahoor H. Premkumar K. Mentor S. Thangavel R. Dubova I. Ahmed M.E. Selvakumar G.P. Kempuraj D. Zaheer S. Iyer S.S. Zaheer A. Next generation precision medicine: CRISPR-mediated genome editing for the treatment of neurodegenerative disorders. J. Neuroimmune Pharmacol. 2019 14 4 608 641 10.1007/s11481‑019‑09849‑y 31011884
    [Google Scholar]
  8. Zeng C.W. Zhang C.L. Neuronal regeneration after injury: A new perspective on gene therapy. Front. Neurosci. 2023 17 1181816 10.3389/fnins.2023.1181816 37152598
    [Google Scholar]
  9. Hampel H. Goetzl E.J. Kapogiannis D. Lista S. Vergallo A. Biomarker-drug and liquid biopsy co-development for disease staging and targeted therapy: Cornerstones for Alzheimer’s precision medicine and pharmacology. Front. Pharmacol. 2019 10 310 10.3389/fphar.2019.00310 30984002
    [Google Scholar]
  10. Alam S. Sarker M.M.R. Afrin S. Richi F.T. Zhao C. Zhou J.R. Mohamed I.N. Traditional herbal medicines, bioactive metabolites, and plant products against COVID-19: Update on clinical trials and mechanism of actions. Front. Pharmacol. 2021 12 671498 10.3389/fphar.2021.671498 34122096
    [Google Scholar]
  11. Ashrafi S. Alam S. Emon N.U. Ahsan M. Isolation, characterization and pharmacological investigations of a new phenolic compound along with four others firstly reported phytochemicals from Glycosmis cyanocarpa (Blume) Spreng. Molecules 2022 27 18 5972 10.3390/molecules27185972 36144708
    [Google Scholar]
  12. Chaachouay N. Zidane L. Plant-derived natural products: A source for drug discovery and development. Drugs and Drug Candidates 2024 3 1 184 207 [https://doi.org/10.3390/ddc3010011]. [http://dx.doi.org/10.3390/ddc3010011
    [Google Scholar]
  13. Can Baser K. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr. Pharm. Des. 2008 14 29 3106 3119 10.2174/138161208786404227 19075694
    [Google Scholar]
  14. Roots of Medicine Available from:https://dsps.lib.uiowa.edu/roots/
  15. Zotti M. Colaianna M. Morgese M. Tucci P. Schiavone S. Avato P. Trabace L. Carvacrol: From ancient flavoring to neuromodulatory agent. Molecules 2013 18 6 6161 6172 10.3390/molecules18066161 23708230
    [Google Scholar]
  16. Mączka W. Twardawska M. Grabarczyk M. Wińska K. Carvacrol-A natural phenolic compound with antimicrobial properties. Antibiotics 2023 12 5 824 10.3390/antibiotics12050824 37237727
    [Google Scholar]
  17. Azizi Z. Majlessi N. Choopani S. Naghdi N. Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review. Avicenna J. Phytomed. 2022 12 4 371 387 10.22038/AJP.2022.19491 35782773
    [Google Scholar]
  18. Lee B. Yeom M. Shim I. Lee H. Hahm D. Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats. Korean J. Physiol. Pharmacol. 2020 24 1 27 37 10.4196/kjpp.2020.24.1.27 31908572
    [Google Scholar]
  19. de Carvalho F.O. Silva J.P.R. Silva É.R. de Albuquerque Júnior R.L.C. Nunes P.S. de Souza Araújo A.A. Would carvacrol be a supporting treatment option effective in minimizing the deleterious effects of COVID-19? Naunyn Schmiedebergs Arch. Pharmacol. 2021 394 12 2471 2474 10.1007/s00210‑021‑02170‑7 34669001
    [Google Scholar]
  20. Wang P. Wu Y. A review on colloidal delivery vehicles using carvacrol as a model bioactive compound. Food. Hydrocoll 2021 120 106922 10.1016/j.foodhyd.2021.10692210.1016/j.foodhyd.2021.106922
    [Google Scholar]
  21. Ares A.M. Nozal M.J. Bernal J.L. Bernal J. Simultaneous determination of carvacrol and thymol in bee pollen by using a simple and efficient solvent extraction method and gas chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 2020 181 113124 10.1016/j.jpba.2020.113124 31986438
    [Google Scholar]
  22. Imran M. Aslam M. Alsagaby S.A. Saeed F. Ahmad I. Afzaal M. Arshad M.U. Abdelgawad M.A. El-Ghorab A.H. Khames A. Shariati M.A. Ahmad A. Hussain M. Imran A. Islam S. Therapeutic application of carvacrol: A comprehensive review. Food Sci. Nutr. 2022 10 11 3544 3561 10.1002/fsn3.2994 36348778
    [Google Scholar]
  23. Carvacrol. Available from:https://pubchem.ncbi.nlm.nih.gov/compound/Carvacrol
  24. de Souza M.M. Andreolla M.C. Ribeiro T.C. Gonçalves A.E. Medeiros A.R. de Souza A.S. Ferreira L.L.G. Andricopulo A.D. Yunes R.A. de Oliveira A.S. Structure–activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer’s disease. RSC Med. Chem. 2020 11 2 307 316 10.1039/D0MD00009D 33479638
    [Google Scholar]
  25. Suntres Z.E. Coccimiglio J. Alipour M. The bioactivity and toxicological actions of carvacrol. Crit. Rev. Food Sci. Nutr. 2015 55 3 304 318 10.1080/10408398.2011.653458 24915411
    [Google Scholar]
  26. Wang Q. Gong J. Huang X. Yu H. Xue F. In vitro evaluation of the activity of microencapsulated carvacrol against Escherichia coli with K88 pili. J. Appl. Microbiol. 2009 107 6 1781 1788 10.1111/j.1365‑2672.2009.04374.x 19645769
    [Google Scholar]
  27. Austgulen L.T. Solheim E. Scheline R.R. Metabolism in rats of p-cymene derivatives: Carvacrol and thymol. Pharmacol. Toxicol. 1987 61 2 98 102 10.1111/j.1600‑0773.1987.tb01783.x 2959918
    [Google Scholar]
  28. Zheng Q. Wang X. Alzheimer’s disease: Insights into pathology, molecular mechanisms, and therapy. Protein Cell 2025 16 2 83 120 10.1093/procel/pwae026 38733347
    [Google Scholar]
  29. Goyal A. Solanki K. Verma A. Luteolin: Nature’s promising warrior against Alzheimer’s and Parkinson’s disease. J. Biochem. Mol. Toxicol. 2024 38 1 e23619 10.1002/jbt.23619 38091364
    [Google Scholar]
  30. Yu M. Engels M.M.A. Hillebrand A. van Straaten E.C.W. Gouw A.A. Teunissen C. van der Flier W.M. Scheltens P. Stam C.J. Selective impairment of hippocampus and posterior hub areas in Alzheimer’s disease: An MEG-based multiplex network study. Brain 2017 140 5 1466 1485 10.1093/brain/awx050 28334883
    [Google Scholar]
  31. Roussarie J.P. Yao V. Rodriguez-Rodriguez P. Oughtred R. Rust J. Plautz Z. Kasturia S. Albornoz C. Wang W. Schmidt E.F. Dannenfelser R. Tadych A. Brichta L. Barnea-Cramer A. Heintz N. Hof P.R. Heiman M. Dolinski K. Flajolet M. Troyanskaya O.G. Greengard P. Selective neuronal vulnerability in Alzheimer’s disease: A network-based analysis. Neuron 2020 107 5 821 835.e12 10.1016/j.neuron.2020.06.010 32603655
    [Google Scholar]
  32. Cassidy L. Fernandez F. Johnson J.B. Naiker M. Owoola A.G. Broszczak D.A. Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics. Complement. Ther. Med. 2020 49 102294 10.1016/j.ctim.2019.102294 32147039
    [Google Scholar]
  33. Siddiqui A. Akhtar S. Shah Z. Othman I. Kumari Y. Inflammation drives Alzheimer’s disease: Emphasis on 5-lipoxygenase pathways. Curr. Neuropharmacol. 2021 19 6 885 895 10.2174/1570159X18666200924122732 32972344
    [Google Scholar]
  34. Vest R.S. Pike C.J. Gender, sex steroid hormones, and Alzheimer’s disease. Horm. Behav. 2013 63 2 301 307 10.1016/j.yhbeh.2012.04.006 22554955
    [Google Scholar]
  35. Esposito Z. Belli L. Toniolo S. Sancesario G. Bianconi C. Martorana A. Amyloid β, glutamate, excitotoxicity in Alzheimer’s disease: are we on the right track? CNS Neurosci. Ther. 2013 19 8 549 555 10.1111/cns.12095 23593992
    [Google Scholar]
  36. Bekdash R.A. The cholinergic system, the adrenergic system and the neuropathology of Alzheimer’s disease. Int. J. Mol. Sci. 2021 22 3 1273 10.3390/ijms22031273 33525357
    [Google Scholar]
  37. Sun B. Zhang X. Yin Y. Sun H. Ge H. Li W. Effects of sulforaphane and vitamin E on cognitive disorder and oxidative damage in lead-exposed mice hippocampus at lactation. J. Trace Elem. Med. Biol. 2017 44 88 92 10.1016/j.jtemb.2017.06.004 28965607
    [Google Scholar]
  38. Diniz do Nascimento L. Moraes A.A.B. Costa K.S. Pereira Galúcio J.M. Taube P.S. Costa C.M.L. Neves Cruz J. de Aguiar Andrade E.H. Faria L.J.G. Bioactive natural compounds and antioxidant activity of essential oils from spice plants: New findings and potential applications. Biomolecules 2020 10 7 988 10.3390/biom10070988 32630297
    [Google Scholar]
  39. Zare Mehrjerdi F. Niknazar S. Yadegari M. Akbari F.A. Pirmoradi Z. Khaksari M. Carvacrol reduces hippocampal cell death and improves learning and memory deficits following lead-induced neurotoxicity via antioxidant activity. Naunyn Schmiedebergs Arch. Pharmacol. 2020 393 7 1229 1237 10.1007/s00210‑020‑01866‑6 32303785
    [Google Scholar]
  40. Azizi Z. Salimi M. Amanzadeh A. Majelssi N. Naghdi N. Carvacrol and thymol attenuate cytotoxicity induced by amyloid β25-35 via activating protein kinase c and inhibiting oxidative stress in PC12 Cells. Iran. Biomed. J. 2020 24 4 243 250 10.29252/ibj.24.4.243 32306722
    [Google Scholar]
  41. Azizi Z. Choopani S. Salimi M. Majlessi N. Naghdi N. Protein kinase C involvement in neuroprotective effects of thymol and carvacrol against toxicity induced by amyloid-β in rat hippocampal neurons. Basic Clin. Neurosci. 2022 13 3 295 304 10.32598/bcn.2021.666.2 36457884
    [Google Scholar]
  42. Medhat D. El-mezayen H.A. El-Naggar M.E. Farrag A.R. Abdelgawad M.E. Hussein J. Kamal M.H. Evaluation of urinary 8-hydroxy-2-deoxyguanosine level in experimental Alzheimer’s disease: Impact of carvacrol nanoparticles. Mol. Biol. Rep. 2019 46 4 4517 4527 10.1007/s11033‑019‑04907‑3 31209743
    [Google Scholar]
  43. Amooheydari Z. Rajaei Z. Alaei H. Esmaeil N. Supplementation of carvacrol attenuates hippocampal tumor necrosis factor-alpha level, oxidative stress, and learning and memory dysfunction in lipopolysaccharide-exposed rats. Adv. Biomed. Res. 2022 11 1 33 10.4103/abr.abr_194_21 35720215
    [Google Scholar]
  44. Caputo L. Amato G. De Martino L. De Feo V. Nazzaro F. Anti-cholinesterase and anti-α-amylase activities and neuroprotective effects of carvacrol and p-cymene and their effects on hydrogen peroxide induced stress in SH-SY5Y cells. Int. J. Mol. Sci. 2023 24 7 6073 10.3390/ijms24076073 37047044
    [Google Scholar]
  45. Kazemi S. Safari S. Komaki S. Karimi S.A. Golipoor Z. Komaki A. The effects of carvacrol and p‐cymene on Aβ 1‐42 ‐induced long‐term potentiation deficit in male rats. CNS Neurosci. Ther. 2024 30 3 e14459 10.1111/cns.14459 37727020
    [Google Scholar]
  46. Shahrokhi Raeini A. Hafizibarjin Z. Rezvani M.E. Safari F. Afkhami Aghda F. Zare Mehrjerdi F. Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion. Naunyn Schmiedebergs Arch. Pharmacol. 2020 393 4 581 589 10.1007/s00210‑019‑01754‑8 31729545
    [Google Scholar]
  47. Hakimi Z. Salmani H. Marefati N. Arab Z. Gholamnezhad Z. Beheshti F. Shafei M.N. Hosseini M. Protective effects of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide-challenged rats. Neurotox. Res. 2020 37 4 965 976 10.1007/s12640‑019‑00144‑5 31811590
    [Google Scholar]
  48. Celik Topkara K. Kilinc E. Cetinkaya A. Saylan A. Demir S. Therapeutic effects of carvacrol on beta‐amyloid‐induced impairments in in vitro and in vivo models of Alzheimer’s disease. Eur. J. Neurosci. 2022 56 9 5714 5726 10.1111/ejn.15565 34904309
    [Google Scholar]
  49. Harper C. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J. Neuropathol. Exp. Neurol. 1998 57 2 101 110 10.1097/00005072‑199802000‑00001 9600202
    [Google Scholar]
  50. Nelson T.E. Ur C.L. Gruol D.L. Chronic intermittent ethanol exposure alters CA1 synaptic transmission in rat hippocampal slices. Neuroscience 1999 94 2 431 442 10.1016/S0306‑4522(99)00336‑X 10579206
    [Google Scholar]
  51. Vetreno R.P. Hall J.M. Savage L.M. Alcohol-related amnesia and dementia: Animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment. Neurobiol. Learn. Mem. 2011 96 4 596 608 10.1016/j.nlm.2011.01.003 21256970
    [Google Scholar]
  52. Wang P. Luo Q. Qiao H. Ding H. Cao Y. Yu J. Liu R. Zhang Q. Zhu H. Qu L. The neuroprotective effects of carvacrol on ethanol-induced hippocampal neurons impairment via the antioxidative and antiapoptotic pathways. Oxid. Med. Cell. Longev. 2017 2017 1 4079425 10.1155/2017/4079425 28191274
    [Google Scholar]
  53. Biessels G.J. Deary I.J. Ryan C.M. Cognition and diabetes: A lifespan perspective. Lancet Neurol. 2008 7 2 184 190 10.1016/S1474‑4422(08)70021‑8 18207116
    [Google Scholar]
  54. Sharma B. Singh N. Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats. Pharmacol. Biochem. Behav. 2011 100 2 320 329 10.1016/j.pbb.2011.08.020 21893084
    [Google Scholar]
  55. Deng W. Lu H. Teng J. Carvacrol attenuates diabetes-associated cognitive deficits in rats. J. Mol. Neurosci. 2013 51 3 813 819 10.1007/s12031‑013‑0069‑6 23877802
    [Google Scholar]
  56. Goyal A. Verma A. Agrawal A. Dubey N. Kumar A. Behl T. Therapeutic implications of crocin in Parkinson’s disease: A review of preclinical research. Chem. Biol. Drug Des. 2023 101 6 1229 1240 10.1111/cbdd.14210 36752710
    [Google Scholar]
  57. Goyal A. Agrawal A. Verma A. Dubey N. The PI3K-AKT pathway: A plausible therapeutic target in Parkinson’s disease. Exp. Mol. Pathol. 2023 129 104846 10.1016/j.yexmp.2022.104846 36436571
    [Google Scholar]
  58. Dati L.M. Ulrich H. Real C.C. Feng Z.P. Sun H.S. Britto L.R. Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model. Neuroscience 2017 356 176 181 10.1016/j.neuroscience.2017.05.013 28526576
    [Google Scholar]
  59. Goldman J.G. Sieg E. Cognitive impairment and dementia in Parkinson disease. Clin. Geriatr. Med. 2020 36 2 365 377 10.1016/j.cger.2020.01.001 32222308
    [Google Scholar]
  60. Haddadi H. Rajaei Z. Alaei H. Shahidani S. Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson’s disease. Arq. Neuropsiquiatr. 2018 76 2 71 77 10.1590/0004‑282x20170193 29489959
    [Google Scholar]
  61. Hamzehloei L. Rezvani M.E. Rajaei Z. Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease. Arq. Neuropsiquiatr. 2019 77 7 493 500 10.1590/0004‑282x20190079 31365641
    [Google Scholar]
  62. Manouchehrabadi M. Farhadi M. Azizi Z. Torkaman-Boutorabi A. Carvacrol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro models of Parkinson’s disease. Neurotox. Res. 2020 37 1 156 170 10.1007/s12640‑019‑00088‑w 31364033
    [Google Scholar]
  63. Tiefensee Ribeiro C. Gasparotto J. Petiz L.L. Brum P.O. Peixoto D.O. Kunzler A. da Rosa Silva H.T. Bortolin R.C. Almeida R.F. Quintans-Junior L.J. Araújo A.A. Moreira J.C.F. Gelain D.P. Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation. Neurochem. Int. 2019 126 27 35 10.1016/j.neuint.2019.02.021 30849398
    [Google Scholar]
  64. Lins L.C.R.F. Souza M.F. Bispo J.M.M. Gois A.M. Melo T.C.S. Andrade R.A.S. Quintans-Junior L.J. Ribeiro A.M. Silva R.H. Santos J.R. Marchioro M. Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine. Brain Res. Bull. 2018 139 9 15 10.1016/j.brainresbull.2018.01.017 29378222
    [Google Scholar]
  65. Baluchnejadmojarad T. Hassanshahi J. Roghani M. Mansouri M. Raoufi S. Protective effect of carvacrol in 6-hydroxydopamine hemi-parkinsonian rat model. J. Basic Clin. Pathophysiol 2014 2 2 29 34
    [Google Scholar]
  66. Hong C. Jeong B. Park H.J. Chung J.Y. Lee J.E. Kim J. Shin Y.C. So I. TRP channels as emerging therapeutic targets for neurodegenerative diseases. Front. Physiol. 2020 11 238 10.3389/fphys.2020.00238 32351395
    [Google Scholar]
  67. Akan T. Aydın Y. Korkmaz O.T. Ulupınar E. Saydam F. The effects of carvacrol on transient receptor potential (TRP) channels in an animal model of Parkinson’s disease. Neurotox. Res. 2023 41 6 660 669 10.1007/s12640‑023‑00660‑5 37452911
    [Google Scholar]
  68. Ahmadi M. Eidi A. Ahmadvand H. Khaksarian M. Sotoodehnejadnematalahi F. Effect of carvacrol on histological analysis and expression of genes involved in an animal model of multiple sclerosis. Mult. Scler. Relat. Disord. 2023 70 104471 10.1016/j.msard.2022.104471 36580874
    [Google Scholar]
  69. Chun Y.L. Kim M. Kim Y.H. Kim N. Yang H. Park C. Huh Y. Jung J. Carvacrol effectively protects demyelination by suppressing transient receptor potential melastatin 7 (TRPM7) in Schwann cells. Anat. Sci. Int. 2020 95 2 230 239 10.1007/s12565‑019‑00514‑1 31848974
    [Google Scholar]
  70. Borowicz-Reutt K. Czernia J. Krawczyk M. Genetic background of epilepsy and antiepileptic treatments. Int. J. Mol. Sci. 2023 24 22 16280 10.3390/ijms242216280 38003469
    [Google Scholar]
  71. Khalil A. Kovac S. Morris G. Walker M.C. Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. Epilepsia 2017 58 2 263 273 10.1111/epi.13645 28084627
    [Google Scholar]
  72. Jeong J.H. Lee S.H. Kho A.R. Hong D.K. Kang D.H. Kang B.S. Park M.K. Choi B.Y. Choi H.C. Lim M.S. Suh S.W. The transient receptor potential melastatin 7 (TRPM7) inhibitors suppress seizure-induced neuron death by inhibiting zinc neurotoxicity. Int. J. Mol. Sci. 2020 21 21 7897 10.3390/ijms21217897 33114331
    [Google Scholar]
  73. Sadegh M. Sakhaie M.H. Carvacrol mitigates proconvulsive effects of lipopolysaccharide, possibly through the hippocampal cyclooxygenase-2 inhibition. Metab. Brain Dis. 2018 33 6 2045 2050 10.1007/s11011‑018‑0314‑3 30229386
    [Google Scholar]
  74. Ghajar J. Traumatic brain injury. Lancet 2000 356 9233 923 929 10.1016/S0140‑6736(00)02689‑1 11036909
    [Google Scholar]
  75. Menon D.K. Unique challenges in clinical trials in traumatic brain injury. Crit. Care Med. 2009 37 1 S129 S135 10.1097/CCM.0b013e3181921225 19104212
    [Google Scholar]
  76. Aarts M. Iihara K. Wei W.L. Xiong Z.G. Arundine M. Cerwinski W. MacDonald J.F. Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell 2003 115 7 863 877 10.1016/S0092‑8674(03)01017‑1 14697204
    [Google Scholar]
  77. Jin J. Desai B.N. Navarro B. Donovan A. Andrews N.C. Clapham D.E. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 2008 322 5902 756 760 10.1126/science.1163493 18974357
    [Google Scholar]
  78. Inoue K. Branigan D. Xiong Z.G. Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J. Biol. Chem. 2010 285 10 7430 7439 10.1074/jbc.M109.040485 20048154
    [Google Scholar]
  79. Lee M. Lee S.H. Choi S. Choi B.Y. Suh S.W. Carvacrol inhibits expression of transient receptor potential melastatin 7 channels and alleviates zinc neurotoxicity induced by traumatic brain injury. Int. J. Mol. Sci. 2022 23 22 13840 10.3390/ijms232213840 36430333
    [Google Scholar]
  80. Li W.T. Zhang S.Y. Zhou Y.F. Zhang B.F. Liang Z.Q. Liu Y.H. Wei Y. Li C.K. Meng X.J. Xia M. Dan Y. Song J.N. Carvacrol attenuates traumatic neuronal injury through store-operated Ca2+ entry-independent regulation of intracellular Ca2+ homeostasis. Neurochem. Int. 2015 90 107 113 10.1016/j.neuint.2015.07.020 26220904
    [Google Scholar]
  81. Galdino P.M. Nascimento M.V.M. Sampaio B.L. Ferreira R.N. Paula J.R. Costa E.A. Antidepressant-like effect of Lafoensia pacari A. St.-Hil. ethanolic extract and fractions in mice. J. Ethnopharmacol. 2009 124 3 581 585 10.1016/j.jep.2009.05.001 19439172
    [Google Scholar]
  82. Andreasen J.T. Olsen G.M. Wiborg O. Redrobe J.P. Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests. J. Psychopharmacol. 2009 23 7 797 804 10.1177/0269881108091587 18583432
    [Google Scholar]
  83. Melo F.H.C. Moura B.A. de Sousa D.P. de Vasconcelos S.M.M. Macedo D.S. Fonteles M.M.F. Viana G.S.B. de Sousa F.C.F. Antidepressant‐like effect of carvacrol (5‐Isopropyl‐2‐methylphenol) in mice: involvement of dopaminergic system. Fundam. Clin. Pharmacol. 2011 25 3 362 367 10.1111/j.1472‑8206.2010.00850.x 20608992
    [Google Scholar]
  84. Dirnagl U. Iadecola C. Moskowitz M.A. Pathobiology of ischaemic stroke: An integrated view. Trends Neurosci. 1999 22 9 391 397 10.1016/S0166‑2236(99)01401‑0 10441299
    [Google Scholar]
  85. Woitzik J. Back T. Thome C. Flow-dependent versus spreading-like impairment of brain tissue integrity during focal cerebral ischemia and its consequences for neuroprotective strategies. Front. Biosci. 2008 13 13 1500 1506 10.2741/2776 17981644
    [Google Scholar]
  86. Danton G.H. Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol. 2003 62 2 127 136 10.1093/jnen/62.2.127 12578222
    [Google Scholar]
  87. Lakhan S.E. Kirchgessner A. Hofer M. Inflammatory mechanisms in ischemic stroke: Therapeutic approaches. J. Transl. Med. 2009 7 1 97 10.1186/1479‑5876‑7‑97 19919699
    [Google Scholar]
  88. Li Z. Hua C. Pan X. Fu X. Wu W. Carvacrol exerts neuroprotective effects via suppression of the inflammatory response in middle cerebral artery occlusion rats. Inflammation 2016 39 4 1566 1572 10.1007/s10753‑016‑0392‑5 27324156
    [Google Scholar]
  89. Chen W. Xu B. Xiao A. Liu L. Fang X. Liu R. Turlova E. Barszczyk A. Zhong X. Sun C.L. Britto L.R. Feng Z.P. Sun H.S. Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis. Mol. Brain 2015 8 11 10.1186/s13041‑015‑0102‑5 25761704
    [Google Scholar]
  90. Zhao H. Sapolsky R.M. Steinberg G.K. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol. Neurobiol. 2006 34 3 249 270 10.1385/MN:34:3:249 17308356
    [Google Scholar]
  91. Yu H. Zhang Z.L. Chen J. Pei A. Hua F. Qian X. He J. Liu C.F. Xu X. Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice. PLoS One 2012 7 3 e33584 10.1371/journal.pone.0033584 22438954
    [Google Scholar]
  92. Nielsen S. Arnulf Nagelhus E. Amiry-Moghaddam M. Bourque C. Agre P. Petter Ottersen O. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci. 1997 17 1 171 180 10.1523/JNEUROSCI.17‑01‑00171.1997 8987746
    [Google Scholar]
  93. Rash J.E. Yasumura T. Hudson C.S. Agre P. Nielsen S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc. Natl. Acad. Sci. USA 1998 95 20 11981 11986 10.1073/pnas.95.20.11981 9751776
    [Google Scholar]
  94. Zhong Z. Wang B. Dai M. Sun Y. Sun Q. Yang G. Bian L. Carvacrol alleviates cerebral edema by modulating AQP4 expression after intracerebral hemorrhage in mice. Neurosci. Lett. 2013 555 24 29 10.1016/j.neulet.2013.09.023 24051341
    [Google Scholar]
  95. Yıldız M.O. Çelik H. Caglayan C. Genç A. Doğan T. Satıcı E. Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis. Metab. Brain Dis. 2022 37 4 1259 1269 10.1007/s11011‑022‑00945‑2 35316447
    [Google Scholar]
  96. Samarghandian S. Farkhondeh T. Samini F. Borji A. Protective effects of carvacrol against oxidative stress induced by chronic stress in rat’s brain, liver, and kidney. Biochem. Res. Int. 2016 2016 1 7 10.1155/2016/2645237 26904286
    [Google Scholar]
  97. Melo F.H.C. Venâncio E.T. De Sousa D.P. De França Fonteles M.M. De Vasconcelos S.M.M. Viana G.S.B. De Sousa F.C.F. Anxiolytic‐like effect of Carvacrol (5‐isopropyl‐2‐methylphenol) in mice: Involvement with GABAergic transmission. Fundam. Clin. Pharmacol. 2010 24 4 437 443 10.1111/j.1472‑8206.2009.00788.x 19909350
    [Google Scholar]
  98. Sauer H. Oertel W.H. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 1994 59 2 401 415 10.1016/0306‑4522(94)90605‑X 7516500
    [Google Scholar]
  99. Perese D.A. Ulman J. Viola J. Ewing S.E. Bankiewicz K.S.A. 6-hydroxydopamine-induced selective parkinsonian rat model. Brain Res. 1989 494 2 285 293 10.1016/0006‑8993(89)90597‑0 2528389
    [Google Scholar]
  100. Mrdenovic D. Pieta I.S. Nowakowski R. Kutner W. Lipkowski J. Pieta P. Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β? Int. J. Biol. Macromol. 2022 200 520 531 10.1016/j.ijbiomac.2022.01.117 35074328
    [Google Scholar]
  101. Yankelevitch-Yahav R. Franko M. Huly A. Doron R. The forced swim test as a model of depressive-like behavior. J. Vis. Exp. 2015 97 52587 10.3791/52587 25867960
    [Google Scholar]
  102. Xu H. Delling M. Jun J.C. Clapham D.E. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci. 2006 9 5 628 635 10.1038/nn1692 16617338
    [Google Scholar]
  103. Zhou H.L. Wang B.B. Fan X.L. Zhang X.M. Song Y. Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos. Ecotoxicol. Environ. Saf. 2025 289 117484 10.1016/j.ecoenv.2024.117484 39644575
    [Google Scholar]
  104. Teleanu D.M. Niculescu A.G. Lungu I.I. Radu C.I. Vladâcenco O. Roza E. Costăchescu B. Grumezescu A.M. Teleanu R.I. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int. J. Mol. Sci. 2022 23 11 5938 10.3390/ijms23115938 35682615
    [Google Scholar]
  105. Guimarães A.G. Oliveira G.F. Melo M.S. Cavalcanti S.C. Antoniolli A.R. Bonjardim L.R. Silva F.A. Santos J.P. Rocha R.F. Moreira J.C. Araújo A.A. Gelain D.P. Quintans-Júnior L.J. Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol. Basic Clini. Pharmacol. Toxicol. 2010 107 6 949 957 10.1111/j.1742‑7843.2010.00609.x 20849525
    [Google Scholar]
  106. Samarghandian S. Farkhondeh T. Samini F. Borji A. Protective effects of carvacrol against oxidative stress induced by chronic stress in rat’s brain, liver, and kidney. BioMed Research Internaltional 2016 2016 2645237 10.1155/2016/2645237 26904286
    [Google Scholar]
  107. Tareen F.K. Catenacci L. Perteghella S. Sorrenti M. Bonferoni M.C. Carvacrol essential oil as a neuroprotective agent: A review of the study designs and recent advances. Molecules 2024 30 1 104 10.3390/molecules30010104 39795159
    [Google Scholar]
  108. Stojanović N.M. Ranđelović P.J. Simonović M. Radić M. Todorović S. Corrigan M. Harkin A. Boylan F. Essential oil constituents as anti-inflammatory and neuroprotective agents: An insight through microglia modulation. Int. J. Mol. Sci. 2024 25 10 5168 10.3390/ijms25105168 38791205
    [Google Scholar]
  109. Zamanian M.Y. Kujawska M. Nikbakhtzadeh M. Hassanshahi A. Ramezanpour S. Kamiab Z. Bazmandegan G. Carvacrol as a potential neuroprotective agent for neurological diseases: A systematic review article. CNS Neurol. Disord. Drug Targets 2021 20 10 942 953 10.2174/1871527320666210506185042 33970850
    [Google Scholar]
  110. Guan X. Li X. Yang X. Yan J. Shi P. Ba L. Cao Y. Wang P. The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019 235 116795 10.1016/j.lfs.2019.116795 31470002
    [Google Scholar]
  111. Sharma H. Yang H. Sharma N. An S.S.A. Trachyspermum ammi bioactives promote neuroprotection by inhibiting acetylcholinesterase, Aβ-oligomerization/fibrilization, and mitigating oxidative stress in vitro. Antioxidants 2023 13 1 9 10.3390/antiox13010009 38275629
    [Google Scholar]
/content/journals/cnsamc/10.2174/0118715249387846251006093402
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  • Article Type:
    Review Article
Keywords: depression ; parkinson's disease ; alzheimer’s disease ; epilepsy ; anxiety ; stroke ; Carvacrol
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