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2000
Volume 25, Issue 3
  • ISSN: 1871-5249
  • E-ISSN: 1875-6166

Abstract

Background

A Non-Ergot Dopamine Agonist (NEDA) rotigotine has been designed as a new transdermal drug delivery system.

Aim

To maintain optimum homogeneity in drug content, the rotigotine transdermal patch was developed utilizing a solvent casting technique.

Methods

The characteristics of a transdermal patch, including patch weight, folding endurance, patch thickness, surface morphology, tensile strength, swelling rate, surface pH, release studies, water retention rate, uniformity of drug content, and permeation studies, were determined.

Results

drug release studies unequivocally demonstrated that drug release controlled polymer interactions. There was no apparent lag period before the drug release rate started to decline.

The developed patch showed 70 ± 1.18% of prolongation of drug release within 24 hours. The result of the penetration studies demonstrated that 61 ± 2.52% of rotigotine permeated through the epidermal barrier within 24 h.

Conclusion

The developed transdermal patch comprising rotigotine was evidently placed on the dermis layer, and an appropriate dose was delivered into circulation for a longer time based on the aforementioned factors. The findings of this study illustrate the effective approach of transdermal patches to treat Parkinson's disease.

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2024-06-21
2025-09-18

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/content/journals/cnsamc/10.2174/0118715249289689240607064642
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The Smart Drug Delivery of Rotigotine Using Transdermal Patch for the Successful Management of Parkinson’s Disease
Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents) 25, 362 (2025); https://doi.org/10.2174/0118715249289689240607064642
/content/journals/cnsamc/10.2174/0118715249289689240607064642
/content/journals/cnsamc/10.2174/0118715249289689240607064642
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  • Article Type:     Research Article
Keyword(s): non-ergot dopamine agonist; Parkinson’s disease; penetration test; rotigotine; solvent casting method; transdermal patch

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