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2000
Volume 21, Issue 5
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Liquid biopsy is a non-invasive diagnostic method that has gained significant attention in the fields of medicine and healthcare. It involves detecting and analyzing biomarkers in bodily fluids, such as blood, urine, or cerebrospinal fluid, to provide valuable information for diagnosis, prognosis, and monitoring of various diseases, particularly cancer. Addressing the need for innovative approaches in the diagnosis and treatment of cancer, researchers are focused on identifying new biomarkers for diagnosis, prognosis, treatment selection, and therapy monitoring.

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2024-06-11
2026-02-13
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References

  1. KimJ. KimM. KangJ.Y. BongK.W. ChoiN. The detection of urinary exosomal miRNAs for cancer diagnostics and prognostics.Biochip J.202317330831710.1007/s13206‑023‑00108‑0
    [Google Scholar]
  2. OshiM. MurthyV. TakahashiH. Urine as a source of liquid biopsy for cancer.Cancers20211311265210.3390/cancers13112652 34071230
    [Google Scholar]
  3. ChenD.S. MellmanI. Oncology meets immunology: the cancer-immunity cycle.Immunity2013391110.1016/j.immuni.2013.07.012
    [Google Scholar]
  4. MirghD. KrishnanA. GoraiS. Sweat exosomes: A new horizon of liquid biopsy in cancer.Journal of Liquid Biopsy2023210012210.1016/j.jlb.2023.100122
    [Google Scholar]
  5. LeeN. CanagasinghamA. BajajM. Urine exosomes as biomarkers in bladder cancer diagnosis and prognosis: From functional roles to clinical significance.Front. Oncol.202212101939110.3389/fonc.2022.1019391 36203422
    [Google Scholar]
  6. BianB. LiL. KeX. Urinary exosomal long non-coding RNAs as noninvasive biomarkers for diagnosis of bladder cancer by RNA sequencing.Front. Oncol.20221297632910.3389/fonc.2022.976329 36119544
    [Google Scholar]
  7. LiX. YangL. Urinary exosomes: Emerging therapy delivery tools and biomarkers for urinary system diseases.Biomed. Pharmacother.202215011305510.1016/j.biopha.2022.113055 35658226
    [Google Scholar]
  8. GroverN. TomarU. TomarS. BhallaK. SinghS. Liquid biopsy and its significance in tumour – detection in the field of pathology.J. Oral Maxillofac. Pathol.202327119520010.4103/jomfp.jomfp_251_22 37234329
    [Google Scholar]
  9. AbinaA. KorošecT. PucU. JazbinšekM. ZidanšekA. Urinary metabolic biomarker profiling for cancer diagnosis by terahertz spectroscopy: Review and perspective.Photonics2023109105110.3390/photonics10091051
    [Google Scholar]
  10. JordaensS. ZwaenepoelK. TjalmaW. Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods.Int. J. Cancer2023152102186220510.1002/ijc.34434 36647333
    [Google Scholar]
  11. BlackwellR.H. FranzenC.A. FlaniganR.C. KuoP.C. GuptaG.N. The untapped potential of urine shed bladder cancer exosomes: Biomarkers, signaling, and therapeutics.Bladder201411e710.14440/bladder.2014.38
    [Google Scholar]
  12. LiS. YiM. DongB. TanX. LuoS. WuK. The role of exosomes in liquid biopsy for cancer diagnosis and prognosis prediction.Int. J. Cancer2021148112640265110.1002/ijc.33386 33180334
    [Google Scholar]
  13. ErozenciL.A. PiersmaS.R. PhamT.V. BijnsdorpI.V. JimenezC.R. Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals.Sci. Rep.20211111562910.1038/s41598‑021‑95082‑8 34341426
    [Google Scholar]
  14. VagoR. RadanoG. ZoccoD. ZarovniN. Urine stabilization and normalization strategies favor unbiased analysis of urinary EV content.Sci. Rep.20221211766310.1038/s41598‑022‑22577‑3 36271135
    [Google Scholar]
  15. ZhouH. YuenP.S.T. PisitkunT. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.Kidney Int.20066981471147610.1038/sj.ki.5000273 16501490
    [Google Scholar]
  16. XuY. LouJ. YuM. Urinary exosomes diagnosis of urological tumors: A systematic review and meta-analysis.Front. Oncol.20211173458710.3389/fonc.2021.734587 34568070
    [Google Scholar]
  17. SalviS. MartignanoF. MolinariC. The potential use of urine cell free DNA as a marker for cancer.Expert Rev. Mol. Diagn.201616121283129010.1080/14737159.2016.1254551 27796148
    [Google Scholar]
  18. PanfoliI. Cancer exosomes in urine: A promising biomarker source.Transl. Cancer Res.20176Suppl. 8101710.21037/tcr.2017.10.17
    [Google Scholar]
  19. HeL. ZhuD. WangJ. WuX. A highly efficient method for isolating urinary exosomes.Int. J. Mol. Med.20194318390 30365060
    [Google Scholar]
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  • Article Type:
    Review Article
Keyword(s): cancer diagnosis; cfDNA; Liquid biopsy; microRNAs; nucleic acid; urinary exosomes
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