Skip to content
2000
Volume 21, Issue 3
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

New therapies for life-threatening ailments like breast carcinoma are urgently required to relieve the ever-increasing burden of the mortality associated with it. The very specific feature associated with life-giving natural products is their lesser toxicity concerning existing strategies chemotherapy or adjuvant modalities. In our review, we have tried to compile the existing data on exploring herbal extracts and bio-actives through various and techniques. An attempt has been made to accumulate data for a scrupulous literature review retrieved pertinent keywords in authentic records. Web of Science, Scopus, and Science Direct. The major keywords included herbal extract, , anticancer, and metastasis. A comprehensive exploration unveiled an imperative role against malignancies of various tissues, but we focussed on breast cancer cell lines. Still, extensive reports on herbal alternatives and their bio-active mechanism are highly implicated in tapping their potential as standardized regimens. Scientific evidence, correlations, and proper safety data may substantiate interventions in cancer therapy.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cctr/10.2174/0115733947293886240215171654
2024-02-28
2025-09-05

  • From This Site

    /content/journals/cctr/10.2174/0115733947293886240215171654
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. HorsburghS. Robson-AnsleyP. AdamsR. SmithC. Exercise and inflammation-related epigenetic modifications: Focus on DNA methylation.Exerc. Immunol. Rev.201521264125826329
     [Google Scholar]
  2. BaskarR. LeeK.A. YeoR. YeohK.W. Cancer and radiation therapy: Current advances and future directions.Int. J. Med. Sci.20129319319910.7150/ijms.363522408567
     [Google Scholar]
  3. WongR.J. CheungR. AhmedA. Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.Hepatology20145962188219510.1002/hep.2698624375711
     [Google Scholar]
  4. VasirJ.K. LabhasetwarV. Targeted drug delivery in cancer therapy.Technol. Cancer Res. Treat.20054436337410.1177/15330346050040040516029056
     [Google Scholar]
  5. IqbalJ. AbbasiB.A. MahmoodT. KanwalS. AliB. ShahS.A. KhalilA.T. Plant-derived anticancer agents: A green anticancer approach.Asian Pac. J. Trop. Biomed.20177121129115010.1016/j.apjtb.2017.10.016
     [Google Scholar]
  6. GreenwellM. RahmanP.K. Medicinal plants: Their use in anticancer treatment.Int. J. Pharm. Sci. Res.20156104103411226594645
     [Google Scholar]
  7. OhiaguF.O. ChikezieP.C. ChikezieC.M. EnyohC.E. Anticancer activity of Nigerian medicinal plants: A review.Futur. J. Pharm. Sci.2021717010.1186/s43094‑021‑00222‑6
     [Google Scholar]
  8. AtanasovA.G. WaltenbergerB. Pferschy-WenzigE.M. LinderT. WawroschC. UhrinP. TemmlV. WangL. SchwaigerS. HeissE.H. RollingerJ.M. SchusterD. BreussJ.M. BochkovV. MihovilovicM.D. KoppB. BauerR. DirschV.M. StuppnerH. Discovery and resupply of pharmacologically active plant-derived natural products: A review.Biotechnol. Adv.20153381582161410.1016/j.biotechadv.2015.08.00126281720
     [Google Scholar]
  9. TrimboliR.M. RossiPG. BattistiN.M.L. CozziA. MagniV. ZanardoM. SardanelliF. Do we still need breast cancer screening in the era of targeted therapies and precision medicine?Insights Imaging202011110510.1186/s13244‑020‑00905‑332975658
     [Google Scholar]
  10. WangL. ZhangS. WangX. The metabolic mechanisms of breast cancer metastasis.Front. Oncol.20211060241610.3389/fonc.2020.60241633489906
     [Google Scholar]
  11. OvadjeP. RomaA. SteckleM. NicolettiL. ArnasonJ.T. PandeyS. Advances in the research and development of natural health products as main stream cancer therapeutics.Evid. Based Complement. Alternat. Med.2015201511210.1155/2015/75134825883673
     [Google Scholar]
  12. FengY. SpeziaM. HuangS. YuanC. ZengZ. ZhangL. JiX. LiuW. HuangB. LuoW. LiuB. LeiY. DuS. VuppalapatiA. LuuH.H. HaydonR.C. HeT.C. RenG. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.Genes Dis.2018527710610.1016/j.gendis.2018.05.00130258937
     [Google Scholar]
  13. JardimD.L. De Melo GagliatoD. NikanjamM. BarkauskasD.A. KurzrockR. Efficacy and safety of anticancer drug combinations: A meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds.OncoImmunology202091171005210.1080/2162402X.2019.171005232002305
     [Google Scholar]
  14. MbuguaRW. NjagiEM NguleCM MwitariP Gene expression mediated antiproliferative potential and safety of selected medicinal plants against cancerous and normal cells.bioRxiv20192019578948
     [Google Scholar]
  15. LevitskyD.O. DembitskyV.M. Anti-breast cancer agents derived from plants.Nat. Prod. Bioprospect.20155111610.1007/s13659‑014‑0048‑925466288
     [Google Scholar]
  16. DesaiA. QaziG. GanjuR. El-TamerM. SinghJ. SaxenaA. BediY. TanejaS. BhatH. Medicinal plants and cancer chemoprevention.Curr. Drug Metab.20089758159110.2174/13892000878582165718781909
     [Google Scholar]
  17. EcclesS.A. WelchD.R. Metastasis: Recent discoveries and novel treatment strategies.Lancet200736995741742175710.1016/S0140‑6736(07)60781‑817512859
     [Google Scholar]
  18. TongY. LiZ. WuY. ZhuS. LuK. HeZ. Lotus leaf extract inhibits ER− breast cancer cell migration and metastasis.Nutr. Metab.20211812010.1186/s12986‑021‑00549‑033602253
     [Google Scholar]
  19. KuoC.Y. WengT.S. KumarK.J.S. TsengY.H. TungT.W. WangS.Y. WangH.C. Ethanol extracts of dietary herb, alpinia nantoensis, exhibit anticancer potential in human breast cancer cells.Integr. Cancer Ther.20191810.1177/153473541986692431409145
     [Google Scholar]
  20. MajumderM. DebnathS. GajbhiyeR.L. SaikiaR. GogoiB. SamantaS.K. DasD.K. BiswasK. JaisankarP. MukhopadhyayR. Ricinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo.Sci. Rep.2019911449310.1038/s41598‑019‑50769‑x31601896
     [Google Scholar]
  21. McGrowderD.A. MillerF.G. NwokochaC.R. AndersonM.S. Wilson-ClarkeC. VazK. Anderson-JacksonL. BrownJ. Medicinal herbs used in traditional management of breast cancer: Mechanisms of action.Medicines2020784710.3390/medicines708004732823812
     [Google Scholar]
  22. ChoiY.K. ChoS.G. WooS.M. YunY.J. ParkS. ShinY.C. KoS.G. Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling.Mediators Inflamm.20142014492173, 11110.1155/2014/49217324976685
     [Google Scholar]
  23. An in vitro model study on the effectiveness of electrical pulse mediated herbal therapy on breast cancer: Effectiveness of electrical pulse mediated herbal therapy.Arch Breast Cancer202292162173
     [Google Scholar]
  24. ZhouR. ChenH. ChenJ. ChenX. WenY. XuL. Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway.BMC Complement. Altern. Med.20181818310.1186/s12906‑018‑2148‑229523109
     [Google Scholar]
  25. LeeMM ChanBD WongWY QuZ ChanMS LeungTW LinY MokDK ChenS TaiWC Anti-cancer activity of centipeda minima extract in triple negative breast cancer via inhibition of AKT, NF-κB, and STAT3 signaling pathways.Front. Oncol.2020 Apr 91049110.3389/fonc.2020.0049132328465
     [Google Scholar]
  26. WongF.C. WooC.C. HsuA. TanB.K.H. The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways.PLoS One2013810e7802110.1371/journal.pone.007802124205071
     [Google Scholar]
  27. HenryD.P. RanjanJ. MuruganR.K. SivananthamA. AlagumuthuM. Exploration of anti-breast cancer effects of Terminalia chebula extract on DMBA-induced mammary carcinoma in Sprague Dawley rats.Futur. J. Pharm. Sci.20206110810.1186/s43094‑020‑00124‑z
     [Google Scholar]
  28. HadisaputriY.E. HabibahU. AbdullahF.F. HalimahE. MutakinM. MegantaraS. AbdulahR. DiantiniA. antiproliferation activity and apoptotic mechanism of soursop (Annona muricata L.) leaves extract and fractions on MCF7 breast cancer cells.Breast Cancer20211344745710.2147/BCTT.S31768234295188
     [Google Scholar]
  29. BharathR. PriyaJ.A. Induction of bax and activation of caspases by hydro ethanolic leaf extract of Citrullus colocynthis (L)-mediated apoptosis in breast cancer cell line (MCF-7).J. Pharm. Res. Int.20213362B173180
     [Google Scholar]
  30. ChaudharyS. ChandrashekarK.S. PaiK.S.R. SettyM.M. DevkarR.A. ReddyN.D. ShojaM.H. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma.BMC Complement. Altern. Med.20151515010.1186/s12906‑015‑0563‑125886964
     [Google Scholar]
  31. ChaoukiW. LegerD.Y. EljastimiJ. BeneytoutJ.L. HmamouchiM. Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7.Pharm. Biol.201048326927410.3109/1388020090309658820645812
     [Google Scholar]
  32. NajmuddinS.U.F.S. RomliM.F. HamidM. AlitheenN.B. Nik Abd RahmanN.M.A. Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line.BMC Complement. Altern. Med.201616131110.1186/s12906‑016‑1290‑y27558166
     [Google Scholar]
  33. ChakravartiB. MauryaR. SiddiquiJ.A. Kumar BidH. RajendranS.M. YadavP.P. KonwarR. In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: Role of pro-apoptotic effects of oleanolic acid and urosolic acid.J. Ethnopharmacol.20121421727910.1016/j.jep.2012.04.01522855944
     [Google Scholar]
  34. KhazaeiS. EsaNM RamachandranV. HamidRA PanduranganAK EtemadA IsmailP In vitro Antiproliferative and apoptosis inducing effect of Allium atroviolaceum Bulb extract on breast, cervical, and liver cancer cells.Front Pharmacol2017 Jan 318510.3389/fphar.2017.0000528197098
     [Google Scholar]
  35. KlaabZM AlmalkiFA HassanA.M. Anticancer activities of ziziphus jujuba extract on breast cancer cells in vitro.Int. J. Pharm. Sci. Rev. Res.2018521125132
     [Google Scholar]
  36. KimY.J. SonD.Y. Hot water leaves extracts of Zizyphus jujube exert antioxidative effects in vitro and cytotoxicity in human cancer cell lines.Hortic. Environ. Biotechnol.201152663564010.1007/s13580‑011‑0040‑9
     [Google Scholar]
  37. YadavNK AryaRK DevK Alcoholic extract of eclipta alba shows in vitro antioxidant and anticancer activity without exhibiting toxicological effects, Hindawi, Oxidative Medicine and Cellular Longevity.Article ID2017909464110.1155/2017/909464
     [Google Scholar]
  38. LamM. CarmichaelA.R. GriffithsH.R. An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.PLoS One201276e4015210.1371/journal.pone.004015222761954
     [Google Scholar]
  39. GuG. BaroneI GelsominoL. GiordanoC BonofiglioD StattiG MenichiniF CatalanoS AndòS Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation.J. Cell. Physiol.2012 Oct227103363337210.1002/jcp.2403522213398
     [Google Scholar]
  40. RayR.B. RaychoudhuriA. SteeleR. NerurkarP. Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.Cancer Res.20107051925193110.1158/0008‑5472.CAN‑09‑343820179194
     [Google Scholar]
  41. NovitasariD. HandayaniS. JenieR.I. Ethanolic extract of hedyotis corymbosa L. inhibits migration and MMP-9 activity on metastatic breast cancer cells.Indones. J. Cancer Chemoprevention201891162210.14499/indonesianjcanchemoprev9iss1pp16‑22
     [Google Scholar]
  42. Nangia-MakkerP. TaitL. ShekharM.P.V. PalominoE. HoganV. PiechockiM.P. FunasakaT. RazA. Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum.Int. J. Cancer2007121488489410.1002/ijc.2273317437270
     [Google Scholar]
  43. ChimpleeS. GraidistP. SrisawatT. SukrongS. BissanumR. KanokwiroonK. Anti‑breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis.Oncol. Lett.20191765283529110.3892/ol.2019.1020931186745
     [Google Scholar]
  44. NagamineM.K. da SilvaT.C. MatsuzakiP. PinelloK.C. CogliatiB. PizzoC.R. AkisueG. HaraguchiM. GórniakS.L. SinhoriniI.L. RaoK.V.K. BarbutoJ.A.M. DagliM.L.Z. Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian Ginseng) on cultured human breast cancer cell line MCF-7.Exp. Toxicol. Pathol.2009611758210.1016/j.etp.2008.01.01718485683
     [Google Scholar]
  45. AlipanahH. ZareianP. Anti-cancer properties of the methanol extract of Boswellia serrata gum resin: Cell proliferation arrest and inhibition of angiogenesis and metastasis in BALB/c mice breast cancer model.Physiol Pharmacol201822183194
     [Google Scholar]
  46. ParrC. AliA.Y. Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.J. Transl. Med.201816128110.1186/s12967‑018‑1660‑y30314527
     [Google Scholar]
  47. SrisawatT. SukpondmaY. ChimpleeS. KanokwiroonK. TedasenA. GraidistP. Extracts from Vatica diospyroides Type SS Fruit Show Low Dose Activity against MDA-MB-468 Breast Cancer Cell-Line via Apoptotic Action.BioMed Res. Int.20142014: 479602, 1810.1155/2014/479602
     [Google Scholar]
  48. AfsarT. TrembleyJ.H. SalomonC.E. RazakS. KhanM.R. AhmedK. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways.Sci. Rep.2016612307710.1038/srep2307726975752
     [Google Scholar]
  49. AbediniM.R. ErfanianN. NazemH. JamaliS. HoshyarR. Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells.Avicenna J. Phytomed.20166214214827222827
     [Google Scholar]
  50. HoshyarR. MohagheghZ. TorabiN. AbolghasemiA. Antitumor activity of aqueous extract of Ziziphus jujube fruit in breast cancer: An in vitro and in vivo study.Asian Pac. J. Reprod.20154211612210.1016/S2305‑0500(15)30007‑5
     [Google Scholar]
  51. AslantürkÖS Aşkın ÇelikT Antioxidant, cytotoxic and apoptotic activities of extracts from medicinal plant Euphorbia platyphyllos L.J. Med. Plants Res.20137191293130410.5897/JMPR.12.608
     [Google Scholar]
  52. WuH. ChenL. ZhuF. HanX. SunL. ChenK. The cytotoxicity effect of resvera-trol: Cell cycle arrest and induced apoptosis of breast cancer 4T1 cells.Toxins (Basel)2019111273110.3390/toxins1112073131847250
     [Google Scholar]
  53. LaiH.W. ChienS.Y. KuoS.J. TsengL.M. LinH.Y. ChiC.W. ChenD.R. Chen D.R. The potential utility of curcumin in the treatment of HER-2-overexpressed breast cancer: An in vitro and in vivo comparison study with herceptin.Evid. Based Complement. Alternat. Med.2012201211210.1155/2012/48656821876713
     [Google Scholar]
  54. HongO.Y. NohE.M. JangH.Y. LeeY.R. LeeB.K. JungS.H. KimJ.S. YounH.J. Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway.Oncol. Lett.201714144144610.3892/ol.2017.610828693189
     [Google Scholar]
  55. GuanX. GuanY. Artemisinin induces selective and potent anticancer effects in drug resistant breast cancer cells by inducing cellular apoptosis and autophagy and G2/M cell cycle arrest.J. BUON20202531330133632862573
     [Google Scholar]
  56. KimJ. YooJ.M. KimJ.S. KimS.G. ParkJ.E. SeokY.M. SonJ.H. KimH.J. Anticancer effect of mountain ginseng.Evid. Based Complement. Alternat. Med.2020202011010.1155/2020/258478332774407
     [Google Scholar]
  57. AyoobI. HazariY.M. LoneS.H. Shakeel-u-Rehman KhurooM.A. FaziliK.M. BhatK.A. Phytochemical and cytotoxic evaluation of Peganum harmala: structure activity relationship studies of harmine.ChemistrySelect20172102965296810.1002/slct.201700232
     [Google Scholar]
  58. BhandariJ. MuhammadB. ThapaP. ShresthaB.G. Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium wallichii.BMC Complement. Altern. Med.201717110210.1186/s12906‑017‑1622‑628178952
     [Google Scholar]
  59. EfferthT. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.Semin. Cancer Biol.201746658310.1016/j.semcancer.2017.02.009
     [Google Scholar]
  60. KumariM PattnaikB RajanSY EGCG-A Promis anti-cancer Phytochem.201732810
     [Google Scholar]
  61. KarthikeyanK. GunasekaranP. RamamurthyN. GovindasamyS. Anticancer activity of Ocimum sanctum.Pharm. Biol.199937428529010.1076/phbi.37.4.285.5801
     [Google Scholar]
  62. RamanujG.K. Antiproliferative and antioxidant effect of Ocimum tenuiflorum leaves extract on breast cancer cell lines: in vitro study.Annals of R.S.C.B.202125664336442
     [Google Scholar]
  63. MehdadA. BrumanaG. SouzaA.A. BarbosaJ.A.R.G. VenturaM.M. de FreitasS.M. A Bowman–Birk inhibitor induces apoptosis in human breast adenocarcinoma through mitochondrial impairment and oxidative damage following proteasome 20S inhibition.Cell Death Discov.2016211506710.1038/cddiscovery.2015.6727551492
     [Google Scholar]
  64. JaradatN.A. Al-RamahiR. ZaidA.N. AyeshO.I. EidA.M. Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine.BMC Complement. Altern. Med.20161619310.1186/s12906‑016‑1070‑826955822
     [Google Scholar]
  65. RajputS. KumarB.N.P. DeyK.K. PalI. ParekhA. MandalM. Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.Life Sci.2013932178379010.1016/j.lfs.2013.09.00924044882
     [Google Scholar]
  66. HsiehC.J. KuoP.L. HsuY.C. HuangY.F. TsaiE.M. HsuY.L. Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.Free Radic. Biol. Med.20146715917010.1016/j.freeradbiomed.2013.10.00424140706
     [Google Scholar]
  67. ChenJ. SaggarJ.K. CoreyP. ThompsonL.U. Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice.J. Nutr.2009139112061206610.3945/jn.109.11250819776177
     [Google Scholar]
  68. DrigginsS.N. MylesE.L. GaryT. The anti-prolific effect of Echinacea Pallida on BT-549 cancer cell line.Cancer Res.2004451010
     [Google Scholar]
  69. MuñozGH. PluchinoS. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer.Maturitas200344Suppl. 1S59S6510.1016/S0378‑5122(02)00349‑312609560
     [Google Scholar]
  70. DaiZ. NairV. KhanM. CiolinoH.P. Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro.Oncol. Rep.20102441087109120811693
     [Google Scholar]
  71. HuangC. WeiY.X. ShenM.C. TuY.H. WangC.C. HuangH.C. Chrysin, abundant in Morinda citrifolia fruit water–etoac extracts, combined with apigenin synergistically induced apoptosis and inhibited migration in human breast and liver cancer cells.J. Agric. Food Chem.201664214235424510.1021/acs.jafc.6b0076627137679
     [Google Scholar]
  72. BozorgiA. KhazaeiS. KhademiA. KhazaeiM. Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells.Iran. J. Basic Med. Sci.202023897098332952942
     [Google Scholar]
  73. MaW. ZhuM. ZhangD. YangL. YangT. LiX. ZhangY. Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2.Phytomedicine201725455110.1016/j.phymed.2016.12.01328190470
     [Google Scholar]
  74. AhmadiankiaN. MoghaddamH.K. MishanM.A. BahramiA.R. Naderi-MeshkinH. BidkhoriH.R. MoghaddamM. MirfeyziS.J. Berberine suppresses migration of MCF-7 breast cancer cells through down-regulation of chemokine receptors.Iran. J. Basic Med. Sci.201619212513127081456
     [Google Scholar]
  75. JiangD. RasulA. BatoolR. SarfrazI. HussainG. Mateen TahirM. QinT. SelamogluZ. AliM. LiJ. LiX. Potential anticancer properties and mechanisms of action of formononetin.BioMed Res. Int.2019201911110.1155/2019/585431531467899
     [Google Scholar]
  76. MontalesM.T.E. RahalO.M. KangJ. RogersT.J. PriorR.L. WuX. SimmenR.C.M. Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells.Carcinogenesis201233365266010.1093/carcin/bgr31722219179
     [Google Scholar]
  77. CookM.T. LiangY. Besch-WillifordC. GoyetteS. MafuvadzeB. HyderS.M. Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts.Springerplus20154144410.1186/s40064‑015‑1242‑x26312209
     [Google Scholar]
  78. SajadianS. VatankhahM. MajdzadehM. KouhsariS.M. GhahremaniM.H. OstadS.N. Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells.Toxicol. Mech. Methods201525538839510.3109/15376516.2015.104565625980655
     [Google Scholar]
  79. DoddapaneniR. PatelK. ChowdhuryN. Noscapine chemosensitization enhances docetaxel anticancer activity and tumor stroma disruption against triple negative breast cancer.AACR2016346657327177833
     [Google Scholar]
  80. TalibW. Regressions of breast carcinoma syngraft following treatment with piperine in combination with thymoquinone.Sci. Pharm.20178532710.3390/scipharm8503002728671634
     [Google Scholar]
  81. KatiyarSS MuntimaduguE RafeeqiTA Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment.Drug Deliv20162372608261610.3109/10717544.2015.1039667
     [Google Scholar]
  82. LeeH. SeoE. KangN. KimW. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells.J. Nutr. Biochem.200819531331910.1016/j.jnutbio.2007.05.00817683926
     [Google Scholar]
  83. KangT.H. SeoJ.H. OhH. YoonG. ChaeJ.I. ShimJ.H. Licochalcone A suppresses specificity protein 1 as a novel target in human breast cancer cells.J. Cell. Biochem.2017118124652466310.1002/jcb.2613128498645
     [Google Scholar]
  84. CuendetM. GuoJ. LuoY. ChenS. OtehamC.P. MoonR.C. van BreemenR.B. MarlerL.E. PezzutoJ.M. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.Cancer Prev. Res. (Phila.)20103222123210.1158/1940‑6207.CAPR‑09‑004920068129
     [Google Scholar]
  85. BodeA.M. DongZ. Chemopreventive effects of licorice and its components.Curr. Pharmacol. Rep.201511607110.1007/s40495‑014‑0015‑532226725
     [Google Scholar]
  86. KwonS.J. ParkS.Y. KwonG.T. LeeK.W. KangY.H. ChoiM.S. YunJ.W. JeonJ.H. JunJ.G. ParkJ.H.Y. Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.Cancer Prev. Res. (Phila.)20136660361310.1158/1940‑6207.CAPR‑13‑001223625311
     [Google Scholar]
  87. GuoY. ZhangX. MengJ. WangZ.Y. An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells.Eur. J. Pharmacol.20116582-311412210.1016/j.ejphar.2011.02.00521376032
     [Google Scholar]
  88. WangX. ZhengN. DongJ. WangX. LiuL. HuangJ. Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells.J. Steroid Biochem. Mol. Biol.201717131832710.1016/j.jsbmb.2017.05.00928529129
     [Google Scholar]
  89. LiY. ZhangT. Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.Future Oncol.2013981097110310.2217/fon.13.10823902242
     [Google Scholar]
  90. RoystonK. UdayakumarN. LewisK. TollefsbolT. A novel combination of withaferin A and sulforaphane inhibit epigenetic machinery, cellular viability and induces apoptosis of breast cancer cells.Int. J. Mol. Sci.2017185109210.3390/ijms1805109228534825
     [Google Scholar]
  91. FengT. CaoW. ShenW. ZhangL. GuX. GuoY. TsaiH. LiuX. LiJ. ZhangJ. LiS. WuF. LiuY. Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.Oncotarget20178132934410.18632/oncotarget.1339327861147
     [Google Scholar]
  92. DribnenkiJ.C.P. McEachernS.F. ChenY. GreenA.G. RashidK.Y. 2149 solin (low linolenic flax).Can. J. Plant Sci.200787229729910.4141/P05‑082
     [Google Scholar]
  93. GoyalA. SharmaV. UpadhyayN. GillS. SihagM. Flax and flaxseed oil: an ancient medicine & modern functional food.J. Food Sci. Technol.20145191633165310.1007/s13197‑013‑1247‑925190822
     [Google Scholar]
  94. TouréA. XuemingX. Flaxseed lignans: Source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits.Compr. Rev. Food Sci. Food Saf.20109326126910.1111/j.1541‑4337.2009.00105.x33467817
     [Google Scholar]
  95. LeeH.E. KimJ.H. KimY.J. ChoiS.Y. KimS-W. KangE. ChungI.Y. KimI.A. KimE.J. ChoiY. RyuH.S. ParkS.Y. An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer.Br. J. Cancer2011104111730173810.1038/bjc.2011.15921559013
     [Google Scholar]
  96. ZielskeS.P. SpaldingA.C. WichaM.S. LawrenceT.S. Ablation of breast cancer stem cells with radiation.Transl. Oncol.20114422723310.1593/tlo.1024721804918
     [Google Scholar]
  97. Al-HajjM. WichaM.S. Benito-HernandezA. MorrisonS.J. ClarkeM.F. Prospective identification of tumorigenic breast cancer cells.Proc. Natl. Acad. Sci. USA200310073983398810.1073/pnas.053029110012629218
     [Google Scholar]
  98. NageenB. SarfrazI. RasulA. HussainG. RukhsarF. IrshadS. RiazA. SelamogluZ. AliM. Eupatilin: a natural pharmacologically active flavone compound with its wide range applications.J. Asian Nat. Prod. Res.202022111610.1080/10286020.2018.149256529973097
     [Google Scholar]
  99. SarfrazI. RasulA. HussainG. HussainS.M. AhmadM. NageenB. JabeenF. SelamogluZ. AliM. Malic enzyme 2 as a potential therapeutic drug target for cancer.IUBMB Life201870111076108310.1002/iub.193030160039
     [Google Scholar]
  100. SharifF. RasulA. AshrafA. HussainG. YounisT. SarfrazI. ChaudhryM.A. BukhariS.A. JiX.Y. SelamogluZ. AliM. Phosphoglycerate mutase 1 in cancer: A promising target for diagnosis and therapy.IUBMB Life201971101418142710.1002/iub.210031169978
     [Google Scholar]
  101. LeeH. LeeS. JeongD. KimS.J. Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells.J. Ginseng Res.201842445546210.1016/j.jgr.2017.05.00330337805
     [Google Scholar]
  102. SujathaP. AnantharajuP.G. VeereshP.M. Diallyl disulfide (DADS) retards the growth of breast cancer cells in vitro and in vivo through apoptosis induction.Biomed. Pharmacol. J.2017101619163010.13005/bpj/1273
     [Google Scholar]
  103. LiuQ. LooW.T.Y. SzeS.C.W. TongY. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFκB, cyclinD and MMP-1 transcription.Phytomedicine2009161091692210.1016/j.phymed.2009.04.00819524420
     [Google Scholar]
  104. PrasadC.P. RathG. MathurS. BhatnagarD. RalhanR. Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/β-catenin signaling.Chem. Biol. Interact.2009181226327110.1016/j.cbi.2009.06.01219573523
     [Google Scholar]
  105. ParedesD.E.E. GarridoJ.C. EutimioM.A.M. Echinacea angustifolia DC extract induces apoptosis and cell cycle arrest and synergizes with paclitaxel in the MDA-MB-231 and MCF-7 human breast cancer cell lines.Nutr. Cancer2020512010.1080/01635581.2020.1817956
     [Google Scholar]
  106. ShangA. CaoS.Y. XuX.Y. GanR.Y. TangG.Y. CorkeH. MavumengwanaV. LiH.B. Bioactive compounds nad biological functions of Garlic (Allium sativum L.).Foods20198724610.3390/foods807024631284512
     [Google Scholar]
  107. SunQ. LiuK. ShenX. JinW. JiangL. Saeed SheikhM. HuY. HuangY. Lappaol F, a novel anticancer agent isolated from plant Arctium lappa L.Mol. Cancer Ther.2014131495910.1158/1535‑7163.MCT‑13‑055224222662
     [Google Scholar]
  108. MaxwellT. ChunS.Y. LeeK.S. KimS. NamK.S. The anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of ER expression.Int. J. Oncol.201750272773510.3892/ijo.2016.382528035371
     [Google Scholar]
  109. DastjerdiM. MehdiabadyE. IranpourF. BahramianH. Effect of thymoquinone on P53 gene expression and consequence apoptosis in breast cancer cell line.Int. J. Prev. Med.2016716610.4103/2008‑7802.18041227141285
     [Google Scholar]
  110. SeoH.S. JoJ.K. KuJ.M. ChoiH.S. ChoiY.K. WooJ.K. KimH. KangS. LeeK. NamK.W. ParkN. JangB.H. ShinY.C. KoS.G. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.Biosci. Rep.2015356e0027610.1042/BSR2015016526500281
     [Google Scholar]
  111. ShanmugamMK AhnKS HsuA Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis.Front Pharmacol20189129410.3389/fphar.2018.01294
     [Google Scholar]
  112. LiangY. Besch-WillifordC. BrekkenR.A. HyderS.M. Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics.Cancer Res.200767209929993610.1158/0008‑5472.CAN‑07‑110317942925
     [Google Scholar]
  113. HashemS AliTA AkhtarS Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.Biomed and Pharmacother.2022150113054
     [Google Scholar]
/content/journals/cctr/10.2174/0115733947293886240215171654
Loading
An Insight into Herbal Interventions for Breast Cancer: A Comprehensive Review
Curr Cancer Ther Rev 21, 287 (2025); https://doi.org/10.2174/0115733947293886240215171654
/content/journals/cctr/10.2174/0115733947293886240215171654
/content/journals/cctr/10.2174/0115733947293886240215171654
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Anticancer; breast carcinoma; cancer therapy; herbal extract; metastasis; secondary metabolites

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test