Current Bioactive Compounds - Online First

Oxazole and the compounds containing sulphonamides are utilized for various treatments of microbial disease as well as for diabetic patients. In the current study, the above moiety synthesizes the new molecule for the treatment of diabetes and microbial infection. The present work involved oxazole-based sulphonamide derivatives by the N-acylation and N-sulphonation. The synthesis was carried out by treating substituted anilines with chloroacetic chloride. The cycloaddition reaction was carried out using triethyl amine as a base catalyst. In the final steps, toluene sulphonyl chloride was used for sulphonation. The synthesized substance was confirmed viaIR, 1H NMR, ESI, Mass spectroscopy, and elemental investigation technique.

Every reagent and starting material used in the synthesis was pure enough to be used as a reagent. To provide an inert environment, the solvents were purified in accordance with conventional laboratory protocols under a nitrogen atmosphere. Melting points are expressed in degrees Celsius and are uncorrected. They were determined by the open capillary technique. KBr pellets and a Shimadzu 8201 PC FTIR spectrophotometer were used to obtain FTIR spectra. Using JEOL and Bruker 500 MHz NMR spectrometers, ~1H and ~13C NMR spectra were obtained in CDCl3 and DMSO-d6, with TMS serving as the internal reference. A Thermo-Finnigan mass spectrophotometer was used to determine the masses of the chemical using the ESI technique.

The present work involved oxazole-based sulphonamides derivatives by the N-acylation and N-sulphonation. The synthesis was carried out by treating substituted anilines with chloroacetic chloride. The cycloaddition reaction was carried out using triethyl amine as a base catalyst. In the final steps, toluene sulphonyl chloride was used for sulphonation. IR, 1HNMR, ESI, Mass spectroscopy and elemental analysis technique confirmed the synthesized compound.

Oxazoles are also related to compounds called 1,3-azoles[nitrogen and oxygen heteroatoms in a 5-membered ring]. Oxazole demonstrates aromaticity since Huckel's rule requires 6π electrons, which are provided by the delocalization of a single pair of electrons from the oxygen atom. It has a wide range of pharmacological aspects like anti-allergic, hypertension, inflammation, schizophrenia, and inflammation. Similarly, sulphonamides are also used as preventive and chemotherapeutic agents against various diseases such as antibacterial, antiprotozoal, antifungal, and translation initiation inhibitors.

The preliminary biological activity was performed on a preliminary level for the antimicrobial and antidiabetic profile. The disc diffusion approach was utilized to achieve the antibacterial activity; similarly diabetic activity was carried out by the induced method. Out of all the synthesized compounds N-[5-[2-[4-bromophenyl amino]acetyloxazole2 yl]-4methylo benzene sulphonamide [4a], N-[5-2[2-FLoro-5nitrophenyl amino]acetyloxazole2yl]-4methylo benzene sulfonamide [4b] show significant effect compared to standard drugs.

Present study deals to access the antidepressant activity of Etlingera elatior leaves extract in rodent.

Etlingera elatior is a species of herbaceous perennial plant in the family Zingiberaceae; native to Indonesia, Thailand, Malaysia and New Guinea. Depression is one of the most common mental disorders affecting humans, pathological basis of which is not fully understood. The current antidepressant drugs have several adverse effects including their effects on cognition. Therefore, natural product are being evaluated for their antidepressant activities.

In this study, Etlingera elatior leaf extracts are being evaluated for antidepressant activity in rodent models. A wide range of synthetic medicines that can be used to treat depression which may exerts various side effects such as dry mouth, gastrointestinal problems, nausea, respiratory problems, cardiac arrhythmias, drowsiness, anxiety etc. Hence, it becomes essential to discover new anti-depressant drug with more potency, efficacy and safety profile than those of marketed synthetic drugs.

Using the forced swimming test, the tail suspension test, mouse 5-HTP-induced head twitches and estimation of brain lipid peroxidation modelsthe antidepressant efficacy of Etlingera elatior ethanolic extract was examined. Imipramine was used as reference standards.

According to our study, Etlingera elatior significantly (p 0.01) reduced immobility in tail suspension, forced swimming, and 5-HTP-induced head twitches in mice with depression that were comparable to imipramine.

Based on the results obtained we can conclude that Etlingera elatior leaves extract possess significant antidepressant activity. The antidepressant effectiveness of Etlingera elatior leaves extract can be confirmed in the future by adding more models, and attempts can also be made to isolate and characterise the phytoconstituents responsible for the pharmacological action.