Recent Advances in Drug Delivery and Formulation - Online First
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Fabrication and Efficacy Assessment of a Combination of Polyherbal Facewash Gels for the Treatment of Propionibacterium acnes
Authors: Suman Shrivastava, Saurabh Shrivastava and Rakesh TirkeyAvailable online: 03 March 2025More LessIntroductionAzadirachta indica is also referred to as margosa or neem. It is found throughout the Indian subcontinent. Aegle marmelos L. (family: Rutaceae), sometimes referred to as Bael in Hindi, is a crucial food plant in India. The fruit has traditionally been used for the treatment of inflammation, diabetes, respiratory disorders, diarrhea, and dysentery. Aegle marmelos fruits are abundant in coumarins, carotenoids, terpenoids, and flavonoids. The plant referred to as Camellia sinensis, or tea, is part of the Theaceae family and is often grown in tropical and subtropical regions.
ObjectiveAcne is a prolonged inflammatory condition of the skin that has a significant negative influence on patients' quality of life all over the world. Although it is most commonly seen in young people, it may impact people of any age. Herbal anti-acne facewash gels were prepared using Carbopol 934 and extracts from Azadirachta indica, Aegle marmelos L., and Camellia sinensis.
Materials and MethodsThe anti-acne facewash gel formulations were prepared in five different concentrations of 1%, 0.90%, 0.80%, 0.60%, and 0.50%, labeled as F1, F2, F3, F4, and F5, respectively.
ResultsThe anti-acne properties of the formulations were evaluated. The outcomes demonstrated gels to have an excellent spreading coefficient, a great physical appearance, and be non-irritating. Standard commercial formulations were used to investigate the effectiveness.
ConclusionUnlike marketed formulations, the developed formulation 3 (F3) demonstrated an excellent spreading coefficient and good % extrudability. It has been shown to be a more potent and effective polyherbal anti-acne facewash gel for treating acne. In recent years, there has been a rise in the patenting of herbal formulations, and several in vitro and in vivo studies have produced scientific proof of their medicinal efficacy. This work discusses many patented herbal compositions and how they might be used therapeutically to treat different diseases.
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Formulation Development and Permeation Studies of Vancomycin Hydrochloride-Loaded Nanostructured Lipid Carrier Incorporated Thermoresponsive In-Situ Gel: A Box-Behnken Design Implemented Approach for Ocular Delivery in Endophthalmitis
Authors: Amit Kumar Singh, Prabhat Kumar Upadhyay and Manish KumarAvailable online: 21 February 2025More LessBackgroundEndophthalmitis, an inflammatory condition of the intraocular cavity, poses a significant challenge in ophthalmology due to its rapid progression and potential for vision loss. Conventional treatment modalities, such as systemic antibiotics or oral administration, often face limitations in achieving the required therapeutic levels at the target site. Hence, repeated intravitreal injections of antibiotics are currently the most preferred and recommended therapy for the management of endophthalmitis, which is an invasive technique and has certain shortcomings, elevated intraocular pressure, bleeding inside the eye, heightened likelihood of retinal detachment, retinal toxicity, and many more. Vancomycin is the first choice drug for the management of endophthalmitis and is given through intravitreal injection.
AimThe work aims to design, develop, and evaluate Vancomycin-loaded NLCs incorporated into an in-situ gel offering a new non-invasive therapeutic option for the management of Endophthalmitis.
MethodThe Vancomycin-loaded NLCs were successfully produced through a double emulsion/solvent evaporation method employing a Box Behnken design. The optimized formulations were incorporated into an in-situ gel system by varying the concentration of Pluronic F127. The formulated gels were characterized for several parameters such as physical appearance, pH, viscosity, gelling strength, gelation temperature, in vitro release profile, and ex-vivo permeation study.
ResultsThe result revealed that the formulation had a smooth appearance with a pH range from 7 to 7.5, was near the physiological pH of the eye, had content in the range of 97.5 ± 1.0%to 99.2 ± 1.0% and gelation temperature near body temperature. The data of release study formulation (VISG2) revealed sustained drug release compared to the control gel. The data ex vivo permeation study revealed that there was approximately a 3 folds increase in permeation of drug form (VISG2) compared to control gel (p˂0.0001) and significant (2.02folds) permeation compared to commercially available formulation (p˂0.0001).
ConclusionIn conclusion, the Vancomycin-loaded NLCs incorporated in-situ gel may serve as a feasible alternative to invasive intravitreal injection for the management of endophthalmitis.
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