Skip to content
2000
Volume 16, Issue 2
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Introduction/Objective

Alternative medicine is a term encompassing several approaches proposed for their healing effects instead of conventional medicine. The present narrative review aimed at exploring the possible use of some popular alternative treatments to manage anxiety and depression, with a specific focus on Bach flowers, lavender oil, and Hypericum which are among the most popular alternative remedies in Italy.

Methods

A thorough search was conducted across electronic databases, such as PubMed, Google Scholar, and PsycINFO for English-written papers published in peer-reviewed journals, available in full-text or abstract. The primary keywords included “Alternative medicine”, “Anxiety”, “Depression”, “Bach Flowers”, “Lavender Oil”, and “Hypericum”. Studies were included if they met the following criteria: focus on the Bach flowers, lavender oil, or hypericum, in the treatment or management of anxiety and depression.

Results

The scientific evidence supporting the benefits of Bach flowers for anxiety and depression is still inconclusive, with some studies suggesting potential benefits in reducing anxiety symptoms and other showing no significant effects. Lavender oil has been explored for its potential therapeutic effects on anxiety and depression, but even in this case the overall findings remain controversial due to methodological limitations. St. John’s Wort (or Hypericum) showed some effect in mild to moderate depression, with efficacy comparable to standard antidepressants and fewer side effects, although its use requires careful cautions when prescribed with other drugs.

Conclusion

The overall findings of the present review would indicate that the scientific evidence about the possible usefulness of Bach flowers, lavender oil, and Hypericum is limited. If the effectiveness of Bach flowers is controversial, some potential benefits of lavender oil and Hypericum have been reported, however they need to be replicated and deepened in controlled clinical studies.

Loading

Article metrics loading...

/content/journals/npj/10.2174/0122103155330395241119082537
2025-01-03
2025-12-13
Loading full text...

Full text loading...

References

  1. CantS. Mainstream Marginality: “non-orthodox” medicine in an “orthodox” Health Service; Gabe, J. CalnanM. Abingdon, UKRoutledge2009177200
    [Google Scholar]
  2. KaptchukT.J. MillerF.G. Viewpoint.Acad. Med.200580328629010.1097/00001888‑200503000‑0001515734812
    [Google Scholar]
  3. VeziariY. LeachM.J. KumarS. Barriers to the conduct and application of research in complementary and alternative medicine: a systematic review.BMC Complement. Altern. Med.201717116610.1186/s12906‑017‑1660‑028335766
    [Google Scholar]
  4. HuffordD.J. Evaluating complementary and alternative medicine: the limits of science and of scientists.J. Law Med. Ethics200331219821210.1111/j.1748‑720X.2003.tb00081.x12964264
    [Google Scholar]
  5. PowerM. HopayianK. Exposing the evidence gap for complementary and alternative medicine to be integrated into science-based medicine.J. R. Soc. Med.2011104415516110.1258/jrsm.2011.10027121502214
    [Google Scholar]
  6. RichardH. Purpose and effectiveness of Complementary and Alternative Medicine (CAM).Glob. J. Med. Med. Sci202211
    [Google Scholar]
  7. OffitP.A. Do you believe in magic?Violence Decline201357
    [Google Scholar]
  8. Traditional, complementary and integrative medicinehttps://www.who.int/health-topics/traditional-complementary-and-integrative-medicine
  9. MaizesV. RakelD. NiemiecC. Integrative medicine and patient-centered care.Explore (NY)20095527728910.1016/j.explore.2009.06.00819733814
    [Google Scholar]
  10. HelmsJ.M. An overview of medical acupuncture.Altern. Ther. Health Med.1998433545[PMID: 9581320
    [Google Scholar]
  11. ClarkeS.J. McLachlanA.J. Interaction between complementary and alternate medicine with conventional anti-cancer medicine.Cancer Forum2020351182310.3316/informit.854155016595505
    [Google Scholar]
  12. GorskiD.H. “Integrative” medicine: integrating quackery with science-based medicine.Cambridge, MAMIT Press Scholarship Online201810.7551/mitpress/9780262037426.003.0014
    [Google Scholar]
  13. SchulzP. HedeV. Alternative and complementary approaches in psychiatry: beliefs versus evidence.Dialogues Clin. Neurosci.201820320721410.31887/DCNS.2018.20.3/pschulz30581290
    [Google Scholar]
  14. ShapiroS. RapaportR. The role of complementary and alternative therapies in pediatric diabetes.Endocrinol. Metab. Clin. North Am.200938479181010.1016/j.ecl.2009.09.00419944293
    [Google Scholar]
  15. HalbersteinR. DeSantisL. SirkinA. Padron-FajardoV. Ojeda-VazM. Healing with Bach® Flower essences: testing a complementary therapy.Complement. Health Pract. Rev.200712131410.1177/1533210107300705
    [Google Scholar]
  16. YangS.W. KooM. WangY.H. The influence of bach rescue remedy on the autonomic response to mental challenge in healthy taiwanese women.Integr. Med. Res.2015418410.1016/j.imr.2015.04.127
    [Google Scholar]
  17. FuscoS.F.B. PancieriA.P. AmancioS.C.P. FuscoD.R. PadovaniC.R. MinicucciM.F. SpiriW.C. BragaE.M. Efficacy of flower therapy for anxiety in overweight or obese adults: A randomized placebo-controlled clinical trial.J. Altern. Complement. Med.202127541642210.1089/acm.2020.030533902293
    [Google Scholar]
  18. SallesL. Effect of flower essences in anxious individuals.Acta Paul. Enferm.20122523824210.1590/S0103‑21002012000200013
    [Google Scholar]
  19. SilvaS.D.G. CamposT.M.P. Topical use of bach flower remedies in a specific vehicle: A therapeutic innovation.Res. Soc. Dev.2023126e12212642029e1221264202910.33448/rsd‑v12i6.42029
    [Google Scholar]
  20. ErnstE. Bach flower remedies: a systematic review of randomised clinical trials.Swiss Med. Wkly.20101403334w13079w1307910.4414/smw.2010.1307920734279
    [Google Scholar]
  21. MonvoisinR. Bach flower remedies: a critic of the pseudoscientific, pseudomedicina concepts and philosophical postures inducted by Dr Bach theory].Ann. Pharm. Fr.200563641642810.1016/S0003‑4509(05)82310‑716292234
    [Google Scholar]
  22. Villarreal-ZegarraD. Taype-RoldanA. Use of unproven treatments in mental health: The case of Bach Flowers.Rev. Fac. Med. (Caracas)201967453310.15446/revfacmed.v67n4.72050
    [Google Scholar]
  23. CavanaghH.M.A. WilkinsonJ.M. Biological activities of Lavender essential oil.Phytother. Res.200216430130810.1002/ptr.110312112282
    [Google Scholar]
  24. BuchbauerG. JirovetzL. JägerW. DietrichH. PlankC. Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation.Z. Naturforsch. C J. Biosci.19914611-121067107210.1515/znc‑1991‑11‑12231817516
    [Google Scholar]
  25. MüllerW.E. SillaniG. SchuwaldA. FriedlandK. Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender.Neurochem. Int.202114310489910.1016/j.neuint.2020.10489933181239
    [Google Scholar]
  26. De SousaD. HocayenP. AndradeL. AndreatiniR. A systematic review of the anxiolytic-like effects of essential oils in animal models.Molecules20152010186201866010.3390/molecules20101862026473822
    [Google Scholar]
  27. MalcolmB.J. TallianK. Essential oil of lavender in anxiety disorders: Ready for prime time?Ment. Health Clin.20177414715510.9740/mhc.2017.07.14729955514
    [Google Scholar]
  28. SchuwaldA.M. NöldnerM. WilmesT. KlugbauerN. LeunerK. MüllerW.E. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.PLoS One201384e5999810.1371/journal.pone.005999823637742
    [Google Scholar]
  29. Sánchez-VidañaD.I. PoK.K.T. FungT.K.H. ChowJ.K.W. LauW.K.W. SoP.K. LauB.W.M. TsangH.W.H. Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats.Neurosci. Lett.201970118019210.1016/j.neulet.2019.02.04230825591
    [Google Scholar]
  30. MalloggiE. MenicucciD. CesariV. FrumentoS. GemignaniA. BertoliA. Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.Appl. Psychol. Health Well-Being202214266369010.1111/aphw.1231034611999
    [Google Scholar]
  31. KasperS. GastparM. MüllerW.E. VolzH.P. MöllerH.J. DienelA. SchläfkeS. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial.Int. Clin. Psychopharmacol.201025527728710.1097/YIC.0b013e32833b324220512042
    [Google Scholar]
  32. DonelliD. AntonelliM. BellinazziC. GensiniG.F. FirenzuoliF. Effects of lavender on anxiety: A systematic review and meta-analysis.Phytomedicine20196515309910.1016/j.phymed.2019.15309931655395
    [Google Scholar]
  33. von KänelR. KasperS. BondolfiG. Holsboer-TrachslerE. HättenschwilerJ. HatzingerM. ImbodenC. HeitlingerE. SeifritzE. Therapeutic effects of Silexan on somatic symptoms and physical health in patients with anxiety disorders: A meta‐analysis.Brain Behav.2021114e0199710.1002/brb3.199733638614
    [Google Scholar]
  34. GrabnarM. RoachM.J. Abd-ElsayedA. KimC. Impact of lavender on pain and anxiety levels associated with spine procedures.Ochsner J.202121435836310.31486/toj.21.001334984050
    [Google Scholar]
  35. KasperS. MüllerW.E. VolzH.P. MöllerH.J. KochE. DienelA. Silexan in anxiety disorders: Clinical data and pharmacological background.World J. Biol. Psychiatry201819641242010.1080/15622975.2017.133104628511598
    [Google Scholar]
  36. ShammasR.L. MarksC.E. BroadwaterG. LeE. GlenerA.D. SergesketterA.R. CasonR.W. RezakK.M. PhillipsB.T. HollenbeckS.T. The effect of lavender oil on perioperative pain, anxiety, depression, and sleep after microvascular breast reconstruction: A prospective, single-blinded, randomized, controlled trial.J. Reconstr. Microsurg.202137653054010.1055/s‑0041‑172446533548936
    [Google Scholar]
  37. BavarsadN.H. BagheriS. Kourosh-AramiM. KomakiA. Aromatherapy for the brain: Lavender’s healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer’s disease: A review article.Heliyon202398e1849210.1016/j.heliyon.2023.e1849237554839
    [Google Scholar]
  38. WoelkH. SchläfkeS. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder.Phytomedicine2010172949910.1016/j.phymed.2009.10.00619962288
    [Google Scholar]
  39. BartovaL. DoldM. VolzH.P. SeifritzE. MöllerH.J. KasperS. Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders: Randomized, placebo-controlled trials revisited.Eur. Arch. Psychiatry Clin. Neurosci.20232731516310.1007/s00406‑022‑01390‑z35262795
    [Google Scholar]
  40. KasperS. An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: An evidence based review.Int. J. Psychiatry Clin. Pract.201317Suppl. 1152210.3109/13651501.2013.813555
    [Google Scholar]
  41. KasperS. VolzH.P. DienelA. SchläfkeS. Efficacy of Silexan in mixed anxiety–depression – A randomized, placebo-controlled trial.Eur. Neuropsychopharmacol.201626233134010.1016/j.euroneuro.2015.12.00226718792
    [Google Scholar]
  42. KimM. NamE.S. LeeY. KangH.J. Effects of lavender on anxiety, depression, and physiological parameters: systematic review and meta-analysis.Asian Nurs. Res.202115527929010.1016/j.anr.2021.11.00134775136
    [Google Scholar]
  43. FiroozeeiT.S. FeiziA. RezaeizadehH. ZargaranA. RoohafzaH.R. KarimiM. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials.Complement. Ther. Med.20215910267910.1016/j.ctim.2021.10267933549687
    [Google Scholar]
  44. Jafari-KoulaeeA. ElyasiF. TaraghiZ. IlaliE.S. MoosazadehM. A systematic review of the effects of aromatherapy with lavender essential oil on depression.Cent. Asian J. Glob. Health202091e44210.5195/cajgh.2020.44235866093
    [Google Scholar]
  45. OgataK. AtakaK. SuzukiH. YagiT. OkawaA. FukumotoT. ZhangB. NakataM. YadaT. AsakawaA. Lavender oil reduces depressive mood in healthy individuals and enhances the activity of single oxytocin neurons of the hypothalamus isolated from mice: A preliminary study.Evid. Based Complement. Alternat. Med.202020201541858610.1155/2020/541858632733584
    [Google Scholar]
  46. FriedlandK. SilaniG. SchuwaldA. StockburgerC. KochE. NöldnerM. MüllerW.E. Neurotrophic properties of silexan, an essential oil from the flowers of lavender-preclinical evidence for antidepressant-like properties.Pharmacopsychiatry2021541374610.1055/a‑1293‑858533254260
    [Google Scholar]
  47. MarchevskyS. Real-world outcomes of long-term use of silexan in patients with anxiety disorders: A single-centre experience.Int. J. Psychiatry Clin. Pract.20241–41410.1080/13651501.2024.239130139154289
    [Google Scholar]
  48. GaleottiN. Hypericum perforatum (St John’s wort) beyond depression: A therapeutic perspective for pain conditions.J. Ethnopharmacol.201720013614610.1016/j.jep.2017.02.01628216196
    [Google Scholar]
  49. RicciutiS. della FarmaciaA. R. Hypericum Perforatum L.
    [Google Scholar]
  50. PatočkaJ. The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L.J. Appl. Biomed.200312617010.32725/jab.2003.010
    [Google Scholar]
  51. SchulzH.U. SchürerM. BässlerD. WeiserD. Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.Arzneimittelforschung2011551152210.1055/s‑0031‑129682015727160
    [Google Scholar]
  52. NicolussiS. DreweJ. ButterweckV. Meyer zu SchwabedissenH.E. Clinical relevance of St. John’s wort drug interactions revisited.Br. J. Pharmacol.202017761212122610.1111/bph.1493631742659
    [Google Scholar]
  53. BennettD.A.Jr PhunL. PolkJ.F. VoglinoS.A. ZlotnikV. RaffaR.B. Neuropharmacology of St. John’s Wort (Hypericum).Ann. Pharmacother.199832111201120810.1345/aph.180269825087
    [Google Scholar]
  54. CzigleS. NagyM. MladěnkaP. TóthJ. Pharmacokinetic and pharmacodynamic herb-drug interactions—part I. Herbal medicines of the central nervous system.PeerJ202311e1614910.7717/peerj.1614938025741
    [Google Scholar]
  55. Canenguez BenitezJ.S. HernandezT.E. SundararajanR. SarwarS. ArriagaA.J. KhanA.T. MatayoshiA. QuintanillaH.A. KochharH. AlamM. MagoA. HansA. BenitezG.A. Advantages and disadvantages of using St. John’s Wort as a treatment for depression.Cureus2022149e2946810.7759/cureus.2946836299970
    [Google Scholar]
  56. BeijaminiV. AndreatiniR. Effects of Hypericum perforatum and paroxetine on rat performance in the elevated T-maze.Pharmacol. Res.200348219920710.1016/S1043‑6618(03)00097‑512798673
    [Google Scholar]
  57. BukhariI.A. DarA. Behavioral profile of Hypericum perforatum (St. John’s Wort) extract. A comparison with standard antidepressants in animal models of depression.Eur. Rev. Med. Pharmacol. Sci.201317810821089[PMID: 23661522
    [Google Scholar]
  58. CanÖ. ÖztürkY. ÖzkayÜ. Effects of insulin and St. John’s Wort treatments on anxiety, locomotory activity, depression, and active learning parameters of streptozotocin-diabetic rats.Planta Med.201177181970197610.1055/s‑0031‑128012921858758
    [Google Scholar]
  59. FiebichB.L. KnörleR. AppelK. KammlerT. WeissG. Pharmacological studies in an herbal drug combination of St. John’s Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.Fitoterapia201182347448010.1016/j.fitote.2010.12.00621185920
    [Google Scholar]
  60. FlausinoO.A.Jr ZangrossiH.Jr SalgadoJ.V. VianaM.B. Effects of acute and chronic treatment with Hypericum perforatum L. (LI 160) on different anxiety-related responses in rats.Pharmacol. Biochem. Behav.2002711-225125710.1016/S0091‑3057(01)00665‑711812530
    [Google Scholar]
  61. HusainG.M. ChatterjeeS.S. SinghP.N. KumarV. Beneficial effect of Hypericum perforatum on depression and anxiety in a type 2 diabetic rat model.Acta Pol. Pharm.2011686913918[PMID: 22125957
    [Google Scholar]
  62. KhalilH.M.A. MahmoudD.B. El-ShiekhR.A. BakrA.F. BoseilaA.A. MehannaS. NaggarR.A. EliwaH.A. Antidepressant and cardioprotective effects of self-nanoemulsifying self-nanosuspension loaded with Hypericum Perforatum on post-myocardial infarction depression in rats.AAPS PharmSciTech202223724310.1208/s12249‑022‑02387‑636028598
    [Google Scholar]
  63. Sevastre-BerghianA.C. TomaV.A. SevastreB. HanganuD. VlaseL. BenedecD. OnigaI. BaldeaI. OlteanuD. MoldovanR. DeceaN. FilipG.A. ClichiciS.V. Characterization and biological effects of Hypericum extracts on experimentally-induced - Anxiety, oxidative stress and inflammation in rats.J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc.201869510.26402/jpp.2018.5.1330683830
    [Google Scholar]
  64. MurckH. Atypical depression and related illnesses--neurobiological principles for their treatment with Hypericum extract.Wien. Med. Wochenschr.200215215-1639840310.1046/j.1563‑258X.2002.02061.x
    [Google Scholar]
  65. LindeK. BernerM.M. KristonL. St John’s wort for major depression.Cochrane Libr.200820084CD00044810.1002/14651858.CD000448.pub318843608
    [Google Scholar]
  66. RT DavidsonJonathan. Effect of Hypericum perforatum (St John’s Wort) in major depressive disorder: A randomized controlled trial.JAMA2002287141807181410.1001/jama.287.14.1807
    [Google Scholar]
  67. SarrisJ. KavanaghD.J. Kava and St. John’s Wort: Current evidence for use in mood and anxiety disorders.J. Altern. Complement. Med.200915882783610.1089/acm.2009.006619614563
    [Google Scholar]
  68. SchraderE. MeierB. BrattströmA. Hypericum treatment of mild–moderate depression in a placebo–controlled study. A prospective, double–blind, randomized, placebo–controlled, multicentre study.Hum. Psychopharmacol. Clin. Exp.199813316316910.1002/(SICI)1099‑1077(199804)13:3<163:AID‑HUP5>3.0.CO;2‑I
    [Google Scholar]
  69. VolzH.-P. Controlled clinical trials of Hypericum extracts in depressed patients - An overview.Pharmacopsychiatry199730(S2)727610.1055/s‑2007‑979522
    [Google Scholar]
  70. WallingA.D. Hypericum in the treatment of patients with depression.Am. Fam. Physician2000611031033104
    [Google Scholar]
  71. WhiskeyE. WernekeU. TaylorD. A systematic review and meta-analysis of Hypericum perforatum in depression: A comprehensive clinical review.Int. Clin. Psychopharmacol.200116523925210.1097/00004850‑200109000‑0000111552767
    [Google Scholar]
  72. BehnkeK. JensenG.S. GraubaumH.J. GruenwaldJ. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression.Adv. Ther.2002191435210.1007/BF0285001712008860
    [Google Scholar]
  73. NgQ.X. VenkatanarayananN. HoC.Y.X. Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis.J. Affect. Disord.201721021122110.1016/j.jad.2016.12.04828064110
    [Google Scholar]
  74. BiliaA.R. GalloriS. VincieriF.F.St. John’s wort and depression.Life Sci.200270263077309610.1016/S0024‑3205(02)01566‑712008092
    [Google Scholar]
  75. BrennerR. AzbelV. MadhusoodananS. PawlowskaM. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: A double-blind, randomized pilot study.Clin. Ther.200022441141910.1016/S0149‑2918(00)89010‑410823363
    [Google Scholar]
  76. ZhengY. CuiY. A meta-analysis on the efficacy and safety of St John’s wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.Neuropsychiatr. Dis. Treat.2016121715172310.2147/NDT.S10675227468236
    [Google Scholar]
  77. KholghiG. Arjmandi-RadS. ZarrindastM.R. VaseghiS.St. Johnʼs wort (Hypericum perforatum) and depression: What happens to the neurotransmitter systems?Naunyn Schmiedebergs Arch. Pharmacol.2022395662964210.1007/s00210‑022‑02229‑z35294606
    [Google Scholar]
  78. ZirakN. ShafieeM. SoltaniG. MirzaeiM. SahebkarA. Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action.J. Cell. Physiol.201923468496850810.1002/jcp.2778130461013
    [Google Scholar]
  79. AyatiZ. SarrisJ. ChangD. EmamiS.A. RahimiR. Herbal medicines and phytochemicals for obsessive–compulsive disorder.Phytother. Res.20203481889190110.1002/ptr.665632124509
    [Google Scholar]
  80. CamfieldD.A. SarrisJ. BerkM. Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence.Prog. Neuropsychopharmacol. Biol. Psychiatry201135488789510.1016/j.pnpbp.2011.02.01121352883
    [Google Scholar]
  81. KobakK.A. TaylorL.V.H. BystritskyA. KohlenbergC.J. GreistJ.H. TuckerP. WarnerG. FuttererR. VapnikT. St John’s wort versus placebo in obsessive-compulsive disorder: Results from a double-blind study.Int. Clin. Psychopharmacol.200520629930410.1097/00004850‑200511000‑0000316192837
    [Google Scholar]
  82. TaylorL.H. KobakK.A. An open-label trial of St. John’s Wort (Hypericum perforatum) in obsessive-compulsive disorder.J. Clin. Psychiatry200061857557810.4088/JCP.v61n080610982200
    [Google Scholar]
  83. KasperS. AnghelescuI-G. SzegediA. DienelA. KieserM. Placebo controlled continuation treatment with Hypericum Extract WS 5570 after recovery from a mild or moderate depressive episode.Wien. Med. Wochenschr.200715713–1436236610.1007/s10354‑007‑0441‑7
    [Google Scholar]
  84. MartinezB. KasperS. RuhrmannS. MöllerH.J. Hypericum in the treatment of seasonal affective disorders.J. Geriatr. Psychiatry Neurol19947(1_suppl)(Suppl. 1)293310.1177/089198879400701s097857504
    [Google Scholar]
  85. WanH. ChenY. Effects of antidepressive treatment of Saint John’s wort extract related to autonomic nervous function in women with irritable bowel syndrome.Int. J. Psychiatry Med.2010401455610.2190/PM.40.1.d20565044
    [Google Scholar]
  86. PetersonB. NguyenH.St. John’s Wort.StatPearls.Treasure Island, FLStatPearls Publishing2024
    [Google Scholar]
  87. ErnstE. PittlerM.H. Alternative therapy bias.Nature1997385661648048010.1038/385480c09020351
    [Google Scholar]
  88. SinghS. ErnstE. Trick or Treatment: the undeniable facts about alternative medicine.New York, United StatesW. W. Norton Company2008
    [Google Scholar]
  89. PurohitM.P. ZafonteR.D. ShermanL.M. DavisR.B. GiwercM.Y. ShentonM.E. YehG.Y. Neuropsychiatric symptoms and expenditure on complementary and alternative medicine.J. Clin. Psychiatry2015767e870e87610.4088/JCP.13m0868226231014
    [Google Scholar]
  90. GorskiD.H. NovellaS.P. Clinical trials of integrative medicine: Testing whether magic works?Trends Mol. Med.201420947347610.1016/j.molmed.2014.06.00725150944
    [Google Scholar]
  91. RavindranA.V. BalneavesL.G. FaulknerG. OrtizA. McIntoshD. MorehouseR.L. RavindranL. YathamL.N. KennedyS.H. LamR.W. MacQueenG.M. MilevR.V. ParikhS.V. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the management of adults with major depressive disorder: Section 5. Complementary and alternative medicine treatments.Can. J. Psychiatry201661957658710.1177/070674371666029027486153
    [Google Scholar]
  92. SarrisJ. RavindranA. YathamL.N. MarxW. RucklidgeJ.J. McIntyreR.S. AkhondzadehS. BenedettiF. CaneoC. CramerH. CribbL. de ManincorM. DeanO. DeslandesA.C. FreemanM.P. GangadharB. HarveyB.H. KasperS. LakeJ. LoprestiA. LuL. MetriN.J. MischoulonD. NgC.H. NishiD. RahimiR. SeedatS. SinclairJ. SuK.P. ZhangZ.J. BerkM. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The world federation of societies of biological psychiatry (WFSBP) and Canadian network for mood and anxiety treatments (canmat) taskforce.World J. Biol. Psychiatry202223642445510.1080/15622975.2021.201304135311615
    [Google Scholar]
/content/journals/npj/10.2174/0122103155330395241119082537
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test