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2000
Volume 15, Issue 6
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

Secondary metabolites from the mangrove-derived fungi have great potential to produce natural products with novel structures and significant biological activities.

Objective

The objective of this study was to isolate and identify the secondary metabolites from the mangrove-derived fungus sp. WHUF0342, and evaluate their antibacterial activities.

Methods

The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel chromatography, and semi-preparative high-performance liquid chromatography (HPLC). Their structures were elucidated by comparing the NMR and MS spectroscopic data with those of literature. The antibacterial activity were evaluated by modified broth microdilution assay.

Results

Eight compounds were isolated from the fermented extracts of the fungus sp. WHUF0342 and identified as chaxine B (), nafuredin (), dichlorodiaportin (), ferulaic acid (), bis(2-ethylhexyl) benzene-1,2-dicarboxylate (), methyl 4-hydroxyphenylacetate (), 4-hydroxyphenyl acetate (), and 4-hydroxyphenylethyl acetate (). Chaxine B () showed antibacterial activity against the phytopathogenic bacterium with a minimum inhibitory concentration (MIC) value of 16 μg/mL. The antibacterial activity against plant pathogen of compound was reported for the first time in this study.

Conclusion

This study not only enriched the secondary metabolites of mangrove-derived fungi but also provided a valuable resource for the prevention of agricultural pathogen infections.

© 2025 Bentham Science Publishers
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2024-05-27
2025-12-13

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Secondary Metabolites from the Mangrove-derived Fungus Trichoderma sp.
Natural Products Journal, The 15, E270524230347 (2025); https://doi.org/10.2174/0122103155311374240517062929
/content/journals/npj/10.2174/0122103155311374240517062929
/content/journals/npj/10.2174/0122103155311374240517062929
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Supplements

The NMR spectra of the compounds are available as supplementary material on the publisher's website along with the published article.

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  • Article Type:     Research Article
Keyword(s): antibacterial steroids; antiphytopathogenic activity; Mangrove-derived fungi; marine natural products; secondary metabolites; Trichoderma sp.

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