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image of Isolation, Pharmacological Properties, Chemical Syntheses, and Biosynthesis of Isobavachalcone (IBC): A Historical Perspective for the Future Direction

Abstract

Isobavachalcone (IBC) is a prenylated flavonoid, originally isolated from , a legume used for centuries in traditional Chinese and Indian medicine to treat various health issues. Known for its diverse biological activities-including antibacterial, anti-inflammatory, anti-tumor, antiviral, neuroprotective, and bone-protective effects-IBC has become a focus of scientific study. This mini-review encompasses key studies of IBC, covering its isolation, pharmacological properties, chemical synthesis, and biosynthesis to benefit both chemists and biologists. The unique chalcone structure and prenyl group on the aromatic ring make IBC particularly intriguing for its wide-ranging bioactivities, synthetic approaches, structural variations, and biosynthetic insights that could aid future drug development and clinical applications.

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2025-04-22
2025-09-13

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Isolation, Pharmacological Properties, Chemical Syntheses, and Biosynthesis of Isobavachalcone (IBC): A Historical Perspective for the Future Direction
Bentham Science Publishers ; https://doi.org/10.2174/0118756298360122250320053005
/content/journals/mroc/10.2174/0118756298360122250320053005
/content/journals/mroc/10.2174/0118756298360122250320053005
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  • Article Type:     Review Article
Keywords: structural diversity ; flavonoid biosynthetic ; prenylated flavonoid ; isobavachalcone ; Natural product ; privilege chalcone scaffold

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