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2000
Volume 22, Issue 8
  • ISSN: 1570-193X
  • E-ISSN: 1875-6298

Abstract

Isoquinoline, quinoline, and pyrimidine are heterocyclic compounds with great potential for developing new drugs. When combined in isoquinoline-pyrimidine-inspired hybrids, they demonstrate numerous beneficial biological properties. Recently, many studies have focused on the synthesis and medicinal chemistry applications of pyrimido[4,5-]isoquinoline ring systems (Py-isoQs4,5-c). This review offers a comprehensive overview of the synthesis of Py-isoQs4,5-c using pyrimidine, 6-amino-1,3-dimethyl-pyrimidine-dione, 6-amino-2-thioxopyrimidinone, 5-chloro-dimethylpyrimidin-4-amine, ethyl benzoate, cyclohexane-dione, cyclopentadiene, benzoquinone, naphthalene-dione, dihydronaphthalenone, isophthalonitrile, dihydroxybenzaldehyde, cyclo-heptanone, furan-methanol, dimethyl but-2-ynedioate, and their derivatives. These compounds are synthesized through various chemical reactions, including condensation, cyclocondensation, alkylation, substitution, one-pot three-component, cross-coupling, Vilsmeier, Suzuki–Miyaura, Diels-Alder reactions, and Pictet–Spengler reactions. These synthetic approaches allow for the efficient construction of Py-isoQs4,5-c, facilitating further exploration and investigation of their potential medicinal applications.

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Recent Developments in the Synthesis, Reactions, and Biological Activities of Pyrimido[4,5-c] Isoquinolines from Pyrimidine Derivatives (Part II)
Mini-Reviews in Organic Chemistry 22, 776 (2025); https://doi.org/10.2174/0118756298330051240923103024
/content/journals/mroc/10.2174/0118756298330051240923103024
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  • Article Type:     Review Article
Keyword(s): 1,2,3-triazole pyrimidoquinazolines; 6-aminopyrimidines; 6-chlorouracil; Diels-Alder reactions; isoquinolinoquinazoline; Pyrimido[4,5-c] isoquinolines

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