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- ISSN: 2210-3031
- E-ISSN: 2210-304X
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Development and In Vitro Assessment of a Pluronic-coconut Oil-lecithin Organogel for Topical Delivery of Lornoxicam in Managing Cervical Spondylosis
- Source: Drug Delivery Letters, Volume 15, Issue 4, Dec 2025, p. 501 - 510
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- 01 Jan 2025
- 22 Apr 2025
- 11 Jul 2025
Abstract
Introduction
Topical delivery via organogels offers a promising method to deliver Lornoxicam directly to the target site with improved bioavailability, avoiding the issues associated with systemic administration.
Methods
In this study, lecithin organogels containing Lornoxicam were developed using the microemulsion technique. First, pure soya lecithin was dispersed in coconut oil, which acted as both the dispersant and emulsifier, at room temperature to form the oily phase. By the following day, the lecithin had wholly dissolved in the mixture. Sorbic acid was added as a preservative. At the same time, Pluronic F-127 was mixed with cold water to form the aqueous phase. Lornoxicam, the active ingredient, was dissolved in polyethylene glycol-400 and combined with the lecithin-coconut oil mixture. The aqueous phase was slowly added to the oily phase while stirring with a homogenizer at 10,000 rpm.
Results and Discussion
The formulated lornoxicam organogel was assessed based on its physical appearance, organoleptic properties such as appearance, color, homogeneity, consistency and texture. Developed formulations were also evaluated for viscosity, spreadability, pH, drug content, and in vitro release characteristics. Formulations F3 and F6 were selected for kinetic studies due to their satisfactory physical properties and maximum drug release.
Conclusion
The transdermal organogel formulation of Lornoxicam was an effective method for topical drug delivery. When applied to the skin, it showed anti-inflammatory and anti-rheumatic effects, making it a viable option for targeted drug delivery for cervical spondylosis.
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