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2000
Volume 15, Issue 4
  • ISSN: 2210-3031
  • E-ISSN: 2210-304X

Abstract

Background

The bioavailability of a variety of drugs has been enhanced by the use of self-nanoemulsifying drug delivery systems (SNEDDS). Despite having several pharmacological effects, myricetin has limited bioavailability because of its poor solubility, which limits its use. Self-nanoemulsifying drug delivery systems (SNEDDS) have been developed to solve this issue.

Aim

The study aims to develop and characterize a self-nanoemulsifying drug delivery system (SNEDDS) of myricetin and evaluate its pharmacokinetics, toxicity, and anti-ulcer activity.

Materials and Methods

Myricetin-SNEDDS was formulated by solubility testing of myricetin in excipients, constructing a pseudo-ternary phase diagram and characterized using emulsification time, percent transmittance, thermodynamic stability, droplet size, polydispersity index and morphological characterization (TEM). Further acute oral toxicity study, pharmacokinetic parameters, antiulcer activity and anti-oxidant activity on stomach tissue for Myricetin-SNEDDS were evaluated.

Results

Tween 80 (surfactant), propylene glycol (co-surfactant) and olive oil (oil phase) were used to prepare myricetin-SNEDDS, which was then optimized according to droplet size and emulsification ability. The obtained Myricetin-SNEDDS ME1F2 with droplet size <100 nm and emulsification time 9s. Further evaluations showed that these Myricetin-SNEDDS have no toxicity and the pharmacokinetic study showed improved systemic drug absorption, which increases oral bioavailability. Myricetin-SNEDDS showed significant anti-ulcer activity and anti-oxidant activity on stomach tissue.

Discussion

The developed Myricetin-SNEDDS significantly enhanced solubility and oral bioavailability compared to pure myricetin. Improved pharmacokinetic parameters, absence of toxicity, and notable anti-ulcer as well as antioxidant activity confirm its therapeutic potential. Thus, SNEDDS can be considered an effective strategy for overcoming the limitations of poorly soluble bioactives like myricetin.

Conclusion

Myricetin's gastroprotective properties and anti-oxidative efficacy can be improved by SNEDDS, according to research, and it has a good probability of becoming a bioactive substance used as an anti-ulcer agent.

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2025-12-22

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Evaluation of Pharmacokinetics, Toxicity, and In Vivo Anti-Ulcer Activity of Myricetin-Loaded Self-Nanoemulsifying Drug Delivery Systems
Drug Deliv Lett 15, 481 (2025); https://doi.org/10.2174/0122103031372608250519104757
/content/journals/ddl/10.2174/0122103031372608250519104757
/content/journals/ddl/10.2174/0122103031372608250519104757
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  • Article Type:     Research Article
Keyword(s): anti-oxidant; anti-ulcer; bioactive substance; bioavailability; Myricetin; SNEDDs

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