Current Organocatalysis - Current Issue

IntroductionA novel immobilized imidazolium type ionic liquid was synthesized using poly(ethylene glycol) (PEG) functionalized magnetic multi-walled carbon nanotubes. This immobilized ionic liquid (MMWCNTs-PEG-IL) was characterized by FT-IR, VSM, XRD, FE-SEM and EDX analysis.MethodsThen, it was used as a magnetic catalyst in a three-component reaction to yield tetrahydrobenzo[b]pyran derivatives. Fi Read More

Backgroundβ-lactams have been primarily utilized as a leading class of effective antibiotics. They have been found to show activity against various diseases, prompting the scientific community to prioritise innovative protocols for their synthesis. The general and well-known synthetic strategy involves the classical Staudinger reaction exhibiting [2+2] cycloaddition reaction. However, the protocol utilizes stoichiometric excess of Read More

IntroductionThe Developed CuO-ZnO nanocomposite has been demonstrated as a new and environmentally friendly catalyst for one-pot multicomponent reaction between aldehydes, 2-naphthol and amides in the synthesis of 1-amidoalkyl-2-naphthols.MethodsThe new catalyst was synthesized by a ball-milling method by mixing a mixture of CuO and ZnO powder in various proportions and characterized by different s Read More

IntroductionIn this study, three amine-tethered DMAP cation bromide catalysts were prepared using two different mole ratios of 4-dimethylpyridine (DMAP) and 3-bromopropylamine hydrobromide (BPA·HBr) in two different solvents, namely, acetonitrile and ethanol. Then, prepared catalysts were employed for CO2 cycloaddition with styrene and propylene epoxides under metal- and solvent-free conditions.MethodsThe impac Read More

BackgroundHydrazide derivatives were synthesized using an organocatalyst, offering an environmentally friendly approach characterized by shorter reaction times, mild conditions, and the use of green solvents.ObjectiveThe objective was to evaluate the synthesized compounds for their anti-tubercular activity against Mycobacterium tuberculosis (Mtb) and to assess the cytotoxicity of active compounds using the MTT assa Read More

BackgroundMono- and bis-(1,4-disubstituted-1,2,3-triazoles) were synthesized via a laccase-catalyzed reaction using Trametes versicolor. This methodology offers a convenient and efficient approach to triazole synthesis under mild conditions, achieving modest to good yields. Additionally, molecular docking studies were performed using PDB IDs 2W9S (antibacterial) and 3KHM (antifungal) to evaluate biological activities. Th Read More

IntroductionThe synthesis of bisindolylalkanes has been carried out for more than two decades using several catalysts.MethodsIn the present study, naturally available orange juice has been demonstrated to be an efficient green catalyst for the synthesis of bisindolylalkanes from the reaction of indoles with different carbonyl compounds.ResultsIn this one-step process, the products were obtained with excellent yield and in a short Read More