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2000
Volume 25, Issue 6
  • ISSN: 1566-5240
  • E-ISSN: 1875-5666

Abstract

Interferon epsilon (IFN-ε) belongs to the type I IFN group and exhibits various biological properties. IFN-ε exhibits different regulation mechanisms and expression other type I IFNs. Its hormonal regulation suggests that this INF can have different functions and pathways from other type I IFNs. Although IFN-ε exhibits lower antiproliferative, anti-tumor, and antiviral activities compared to IFN-α, it has been identified to contribute to mucosal immunity, combat bacterial infections, and aid in the prevention of specific sexually transmitted diseases, such as HIV, Zika virus, . IFN-α and IFN-β with their well-established properties have been a research hotspot for many years; nevertheless, IFN-ε, whose unique roles are only now beginning to emerge, may be an intriguing subject for future study. This review focuses on the known activity of IFN-ε in certain cancers, pregnancy, autoimmune diseases, bacterial infections, and viruses. The aim of this paper is to enhance the understanding of the potential efficacy of IFN-ε treatment in the future.

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Interferon Epsilon: Properties and Functions
Current Molecular Medicine 25, 723 (2025); https://doi.org/10.2174/0115665240309075240603062703
/content/journals/cmm/10.2174/0115665240309075240603062703
/content/journals/cmm/10.2174/0115665240309075240603062703
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  • Article Type:     Review Article
Keyword(s): anti-tumor; antiviral; autoimmune diseases; IFN-α; Interferon epsilon; PRP

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