Current Indian Science - Volume 1, Issue 1, 2023

The purpose of the study was to investigate the role of the endocannabinoid system and the therapeutic potential benefits of cannabinoids in Alzheimer’s disease. The most frequent form of dementia in older individuals is Alzheimer's disease (AD), a progressive neurological ailment that gradually deprives people of their memory, cognitive abilities, and, ultimately, their ability to perform daily tasks. Alzheimer's disease is Read More

Concerning the past few years in terms of health and nature, the globe has witnessed an upsurge in the use of nutraceuticals and nutritional and natural products in therapeutics. The major reason for this step is the conventional pharmacological treatment using synthetic drugs that do not meet the status of health and therapeutic requirements for various pathological conditions. Nutraceuticals promise prominent health an Read More

Background Traditional approach to shelf-life prediction claims a substantial amount of product development time, leading to significant delays. Objective The capability of the unconventional Accelerated Stability Assessment Program (ASAP) to decode chemical stability and expedite shelf-life prediction is discussed in the manuscript. Methods As per the ASAP approach, shelf-life limiting attributes for two APIs’ and a formulation Read More

Background Diabetes, high cholesterol, and high blood pressure all considerably raise the risk of cardiovascular disease. When all three of these characteristics occur at once, a metabolic problem is postulated. A combination of antihypertensive, hypolipidemic, and anti-diabetic medications is frequently utilised to treat cardiovascular diseases. While statins (fluvastatin, simvastatin, etc.) are used to lower cholesterol levels, calci Read More

Naringin is a naturally obtained chemical from plants that is formed as a secondary metabolite in them. It possesses significant properties that are useful to humans. The primary sources of naringin extract include fruits of the citrus family which are Citrus reticulata, Citrus bergamia, Citrus aurantium, and Citrus paradisi. It belongs to a class of alcohols primarily consisting of a fused ring system which is responsible for its diff Read More

Arthritis is one of the major inflammatory diseases and is a global issue. Arthritis is currently an utmost public health problem and it severely affects impact the life of the geriatric population. There are several types of arthritis such as Rheumatoid arthritis, Osteoarthritis, Gout, and Fibromyalgia, which limit the mobility of the patient. In most cases, the reason for the disease is not known clearly and available treatment can reduce Read More

Background Vidangalilouham (VDL) is an Ayurveda classical Indian herbomineral preparation prescribed for its effective antidiabetic activity. Among the official formulations of Ayurveda, five different compositions are available by the same name. The particular composition used in this study is only marketed but has yet to be evaluated. Aim and Objective The study aimed to assess and validate the antihyperglycemic activity of Read More

Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the most contagious and fatal human pathogens which necessitates the development of modified existing drugs or derivatives with action against novel targets. Aims and Objectives In the present work, we have explored a few, 2-(5-(substituted)-4H-1,2,4-triazole-2-ylthio)-N-(substituted) phenyl acetamide (5A-5E) derivatives as anti-TB. M Read More

Convolvulus prostratus, also known as sankhapushpi, is a very adaptable plant frequently used as a nervine tonic, nootropic, and rejuvenator in cases of insanity and epilepsy and has a broad spectrum of beneficial properties. Several medicinal qualities, including anxiety, neuroprotective, antioxidant, analgesic, immunomodulatory, antibacterial, antidiabetic, and cardioprotective effects, have been related to this herb in an Read More

Around 2.5% of persons will experience obsessive-compulsive disorder (OCD), which has a significant morbidity. About 70% of individuals might have significant symptom relief with the correct medicine. Pharmacological therapy is based on a class of drugs called selective serotonin reuptake inhibitors (SSRIs). They are frequently given in higher doses and for longer durations compared to depression. Unfortunately, remission i Read More

Despite the evident success of antiretroviral therapy in recent years, many patients undergoing intense treatment still struggle to find a cure for their disease due to drug resistance or treatment failure. To solve this problem, new antiretroviral drug alternatives are required. The HIV-1 antiretroviral drug fostemsavir (GSK3684394, previously BMS-663068) is a first-in-class HIV-1 attachment inhibitor with a novel mechani Read More

Background Cancer is caused by dysregulation of the cell cycle, which results in abnormal proliferation and the inability of cells to differentiate or die. Cyclins and cyclin-dependent kinases (CDK4) inhibitors are drugs that target a specific enzyme, CDK4 that controls cell cycle progression in cancer. Aim & Objective The aim of this study is to obtain an optimized pharmacophore of pyrrolo[2,3-d] pyrimidine as a CDK4 inhibitor Read More

This article aims to highlight the most recent information on the “tomato flu” epidemic in India. A new disease has sprung out in several areas of India. The illness had a rash that was predominantly seen in children under the age of five and was highly infectious. It was known as “tomato flu” because the rash was excruciatingly painful, and the blisters were the size of tiny tomatoes. None of the afflicted children experienced p Read More

Background Diabetes is one of the most escalating endocrine disorders around the global countries. Researchers are paying more attention towards herbal drugs for treating these chronic ailments. As per the statistics, the incidence of diabetes is increasing not only in adults but also in neonates. Herbal plants like Okra and Neem have been used in India since the ages to treat various kinds of ailments. Methods The met Read More

Background & Objective The treatment of diseases and good health maintenance are the common fundamental aims of ayurvedic and allopathic medical systems. Limited information is available in the public domain for the concept of symbiohealth, i.e., the symbiotic interaction of ayurveda and allopathy, that needs to be explored for an efficient and robust health system. Therefore, an attempt has been made to reduce the Read More

Background A plant from the Acanthaceae family, Hygrophila spinosa T. Ander is geographically distributed throughout Asia and is noted for its diuretic and aphrodisiac properties in Ayurvedic literature. In the last four decades, various research teams have conducted experiments with the plant Hygrophila spinosa to screen the plant for hepatoprotective, anti-urolithiasis, diuretic, anti-hypertensive, anti-diabetic, chemoprote Read More

Background Colorectal cancer is still challenging for scientists and healthcare professionals. Conventional treatment methods are associated with various limitations at a clinical bed and patient’s compliance. Novel nanocarrier based approaches opened a new window for improved therapy and new future perspective. Introduction Cancer is the deadliest disease globally and is challenging to healthcare systems. Colorectal cancer Read More

Background Wound healing is a dynamic process that is affected by various processes. Medications involved in wound healing can interfere with clot formation, inflammation reduction, and cell proliferation. Collagen is the natural existing compound that has the ability to enhance tissue regeneration. Various drugs used for healing have cons like inhibiting DNA, RNA, or protein synthesis, resulting in decreased fibroplasias Read More

Purpose of the study In our present work, we have considered a simple parametric form of the Hubble parameter (H) for a canonical scalar field model described within a spatially flat FRW spacetime framework. Here we have considered a well-behaved parametrization scheme of the normalized Hubble parameter to explain the expansion history of the universe. Methods Under this scenario, we have obtained the anal Read More

Background Developmental toxicology deals with the effects of compounds on fertility and with birth defects that could occur at any stage of the reproductive cycle. In this study, we evaluated the teratogenic effects of Lablab purpureus (L.) Sweet beans on zebrafish embryo. Objectives The developmental toxicity study was carried out to evaluate the toxicity induced by Lablab purpureus (L.) Sweet beans on zebrafish embryo Read More