Skip to content
2000
Volume 17, Issue 2
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

The discovery of the immune checkpoint inhibitors such as programed cell death-1 protein/ Programmed death ligand-1 or 2 and (PD-1/PD-L1 or PD-L2) and Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) paved the way for developing novel cancer treatment. The check point inhibitors are found to be very efficient in treating many hot tumors (with immune environment) such as bladder cancer, melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), etc. Numerous clinical trials have been initiated to evaluate the safety and effectiveness of immune checkpoint inhibitors for patients with different cancer types, including hepatocellular carcinoma (HCC), pancreatic and prostate cancer. The results and findings of these trials are highly appreciated. However, the search for check point inhibitors with better efficacy for the treatment of HCC is still going on. The present review focuses on advancement in HCC treatments with respect to various standard therapies and immunotherapy.

Loading

Article metrics loading...

/content/journals/cctr/10.2174/1573394716999200818103724
2021-05-01
2025-09-06
Loading full text...

Full text loading...

/content/journals/cctr/10.2174/1573394716999200818103724
Loading

  • Article Type:
    Review Article
Keyword(s): CTLA-4 inhibitors; GITR; HCC; LAG-3; PD-1 inhibitors; sorafenib; TACE
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test