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image of A Mini Overview of Recent Herbal Medicines Innovations Progress against Benign Prostate Hyperplasia

Abstract

Introduction

Benign Prostatic Hyperplasia (BPH) is a common urological condition affecting aging men, characterized by prostate gland enlargement and lower urinary tract symptoms. This review aims to explore the causes, diagnosis, and treatment strategies for BPH, focusing on both conventional medicine and alternative therapies, particularly those from Ayurveda and Homeopathy.

Methods

A comprehensive literature review was conducted using databases such as PubMed, Google Scholar, and ScienceDirect. The study adopted a multidisciplinary approach to assess genetic, hormonal, and environmental contributors to BPH. Conventional treatment modalities, including pharmacological and surgical interventions, were analysed alongside their limitations. The pharmacological potential of medicinal plants traditionally used in Ayurveda and Homeopathy was examined, focusing on their bioactive compounds and mechanisms of action.

Results

Findings highlight the growing interest in plant-based therapies due to their favorable safety profiles and potential multi-targeted mechanisms. Several medicinal plants, such as Serenoa repens, Withania somnifera, and Urtica dioica, demonstrate anti-inflammatory, anti-androgenic, and antioxidant activities beneficial in BPH management. The review underscores the therapeutic value of integrating phytotherapy with conventional care to enhance treatment efficacy and patient outcomes.

Discussion

Bridging traditional knowledge systems with evidence-based research may offer novel insights into BPH therapy. While challenges persist in standardizing herbal formulations and conducting rigorous clinical trials, preliminary findings are encouraging.

Conclusion

Integrating traditional medicinal knowledge with modern scientific validation may lead to safe, effective, and innovative therapies for BPH, ultimately improving the quality of life for affected individuals.

© 2025 Bentham Science Publishers
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/content/journals/cctr/10.2174/0115733947375503250326074355
2025-04-15
2025-10-21

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References

  1. Yeh H.F. Li T.F. Tsai C.H. Wu P.W. Huang Y.H. Huang W.J. Chen F.J. Hwang S.J. Chen F.P. Wu T.P. The effects of a Chinese herbal medicine (VGHBPH0) on patients with benign prostatic hyperplasia: A pilot study. J. Chin. Med. Assoc. 2020 83 10 967 971 10.1097/JCMA.0000000000000384 32649417
    [Google Scholar]
  2. Brauer M. Roth G.A. Aravkin A.Y. Zheng P. Abate K.H. Abate Y.H. Abbafati C. Abbasgholizadeh R. Abbasi M.A. Abbasian M. Abbasifard M. Abbasi-Kangevari M. Abd ElHafeez S. Abd-Elsalam S. Abdi P. Abdollahi M. Abdoun M. Abdulah D.M. Abdullahi A. Abebe M. Abedi A. Abedi A. Abegaz T.M. Abeldaño Zuñiga R.A. Abiodun O. Abiso T.L. Aboagye R.G. Abolhassani H. Abouzid M. Aboye G.B. Abreu L.G. Abualruz H. Abubakar B. Abu-Gharbieh E. Abukhadijah H.J.J. Aburuz S. Abu-Zaid A. Adane M.M. Addo I.Y. Addolorato G. Adedoyin R.A. Adekanmbi V. Aden B. Adetunji J.B. Adeyeoluwa T.E. Adha R. Adibi A. Adnani Q.E.S. Adzigbli L.A. Afolabi A.A. Afolabi R.F. Afshin A. Afyouni S. Afzal M.S. Afzal S. Agampodi S.B. Agbozo F. Aghamiri S. Agodi A. Agrawal A. Agyemang-Duah W. Ahinkorah B.O. Ahmad A. Ahmad D. Ahmad F. Ahmad N. Ahmad S. Ahmad T. Ahmed A. Ahmed A. Ahmed A. Ahmed L.A. Ahmed M.B. Ahmed S. Ahmed S.A. Ajami M. Akalu G.T. Akara E.M. Akbarialiabad H. Akhlaghi S. Akinosoglou K. Akinyemiju T. Akkaif M.A. Akkala S. Akombi-Inyang B. Al Awaidy S. Al Hasan S.M. Alahdab F. AL-Ahdal T.M.A. Alalalmeh S.O. Alalwan T.A. Al-Aly Z. Alam K. Alam N. Alanezi F.M. Alanzi T.M. Albakri A. AlBataineh M.T. Aldhaleei W.A. Aldridge R.W. Alemayohu M.A. Alemu Y.M. Al-Fatly B. Al-Gheethi A.A.S. Al-Habbal K. Alhabib K.F. Alhassan R.K. Ali A. Ali A. Ali B.A. Ali I. Ali L. Ali M.U. Ali R. Ali S.S.S. Ali W. Alicandro G. Alif S.M. Aljunid S.M. Alla F. Al-Marwani S. Al-Mekhlafi H.M. Almustanyir S. Alomari M.A. Alonso J. Alqahtani J.S. Alqutaibi A.Y. Al-Raddadi R.M. Alrawashdeh A. Al-Rifai R.H. Alrousan S.M. Al-Sabah S.K. Alshahrani N.Z. Altaany Z. Altaf A. Al-Tawfiq J.A. Altirkawi K.A. Aluh D.O. Alvis-Guzman N. Alvis-Zakzuk N.J. Alwafi H. Al-Wardat M.S. Al-Worafi Y.M. Aly H. Aly S. Alzoubi K.H. Al-Zyoud W. Amaechi U.A. Aman Mohammadi M. Amani R. Amiri S. Amirzade-Iranaq M.H. Ammirati E. Amu H. Amugsi D.A. Amusa G.A. Ancuceanu R. Anderlini D. Anderson J.A. Andrade P.P. Andrei C.L. Andrei T. Anenberg S.C. Angappan D. Angus C. Anil A. Anil S. Anjum A. Anoushiravani A. Antonazzo I.C. Antony C.M. Antriyandarti E. Anuoluwa B.S. Anvari D. Anvari S. Anwar S. Anwar S.L. Anwer R. Anyabolo E.E. Anyasodor A.E. Apostol G.L.C. Arabloo J. Arabzadeh Bahri R. Arafat M. Areda D. Aregawi B.B. Aremu A. Armocida B. Arndt M.B. Ärnlöv J. Arooj M. Artamonov A.A. Artanti K.D. Aruleba I.T. Arumugam A. Asbeutah A.M. Asgary S. Asgedom A.A. Ashbaugh C. Ashemo M.Y. Ashraf T. Askarinejad A. Assmus M. Astell-Burt T. Athar M. Athari S.S. Atorkey P. Atreya A. Aujayeb A. Ausloos M. Avila-Burgos L. Awoke A.A. Ayala Quintanilla B.P. Ayatollahi H. Ayestas Portugal C. Ayuso-Mateos J.L. Azadnajafabad S. Azevedo R.M.S. Azhar G.S. Azizi H. Azzam A.Y. Backhaus I.L. Badar M. Badiye A.D. Bagga A. Baghdadi S. Bagheri N. Bagherieh S. Bahrami Taghanaki P. Bai R. Baig A.A. Baker J.L. Bakkannavar S.M. Balasubramanian M. Baltatu O.C. Bam K. Bandyopadhyay S. Banik B. Banik P.C. Banke-Thomas A. Bansal H. Barchitta M. Bardhan M. Bardideh E. Barker-Collo S.L. Bärnighausen T.W. Barone-Adesi F. Barqawi H.J. Barrero L.H. Barrow A. Barteit S. Basharat Z. Basiru A. Basso J.D. Bastan M-M. Basu S. Batchu S. Batra K. Batra R. Baune B.T. Bayati M. Bayileyegn N.S. Beaney T. Behnoush A.H. Beiranvand M. Béjot Y. Bekele A. Belgaumi U.I. Bell A.W. Bell M.L. Bello M.B. Bello O.O. Belo L. Beloukas A. Bendak S. Bennett D.A. Bennitt F.B. Bensenor I.M. Benzian H. Beran A. Berezvai Z. Bernabe E. Bernstein R.S. Bettencourt P.J.G. Bhagavathula A.S. Bhala N. Bhandari D. Bhardwaj N. Bhardwaj P. Bhaskar S. Bhat A.N. Bhat V. Bhatti G.K. Bhatti J.S. Bhatti M.S. Bhatti R. Bhuiyan M.A. Bhutta Z.A. Bikbov B. Bishai J.D. Bisignano C. Biswas A. Biswas B. Biswas R.K. Bjørge T. Boachie M.K. Boakye H. Bockarie M.J. Bodolica V. Bodunrin A.O. Bogale E.K. Bolla S.R. Boloor A. Bonakdar Hashemi M. Boppana S.H. Bora Basara B. Borhany H. Botero Carvajal A. Bouaoud S. Boufous S. Bourne R. Boxe C. Braithwaite D. Brant L.C. Brar A. Breitborde N.J.K. Breitner S. Brenner H. Briko A.N. Britton G. Brown C.S. Browne A.J. Brunoni A.R. Bryazka D. Bulamu N.B. Bulto L.N. Buonsenso D. Burkart K. Burns R.A. Busse R. Bustanji Y. Butt N.S. Butt Z.A. Caetano dos Santos F.L. Cagney J. Cahuana-Hurtado L. Calina D. Cámera L.A. Campos L.A. Campos-Nonato I.R. Cao C. Cao F. Cao Y. Capodici A. Cárdenas R. Carr S. Carreras G. Carrero J.J. Carugno A. Carvalho F. Carvalho M. Castaldelli-Maia J.M. Castañeda-Orjuela C.A. Castelpietra G. Catalá-López F. Catapano A.L. Cattaruzza M.S. Caye A. Cederroth C.R. Cegolon L. Cenderadewi M. Cercy K.M. Cerin E. Chadwick J. Chakraborty C. Chakraborty P.A. Chakraborty S. Chan J.S.K. Chan R.N.C. Chandan J.S. Chandika R.M. Chaturvedi P. Chen A-T. Chen C.S. Chen H. Chen M.X. Chen M. Chen S. Cheng C-Y. Cheng E.T.W. Cherbuin N. Chi G. Chichagi F. Chimed-Ochir O. Chimoriya R. Ching P.R. Chirinos-Caceres J.L. Chitheer A. Cho W.C.S. Chong B. Chopra H. Chowdhury R. Christopher D.J. Chu D-T. Chukwu I.S. Chung E. Chung S-C. Chutiyami M. Cioffi I. Cogen R.M. Cohen A.J. Columbus A. Conde J. Corlateanu A. Cortese S. Cortesi P.A. Costa V.M. Costanzo S. Criqui M.H. Cruz J.A. Cruz-Martins N. Culbreth G.T. da Silva A.G. Dadras O. Dai X. Dai Z. Daikwo P.U. Dalli L.L. Damiani G. D’Amico E. D’Anna L. Darwesh A.M. Das J.K. Das S. Dash N.R. Dashti M. Dávila-Cervantes C.A. Davis Weaver N. Davitoiu D.V. De la Hoz F.P. de la Torre-Luque A. De Leo D. Debopadhaya S. Degenhardt L. Del Bo’ C. Delgado-Enciso I. Delgado-Saborit J.M. Demoze C.K. Denova-Gutiérrez E. Dervenis N. Dervišević E. Desai H.D. Desai R. Devanbu V.G.C. Dewan S.M.R. Dhali A. Dhama K. Dhane A.S. Dhimal M.L. Dhimal M. Dhingra S. Dhulipala V.R. Dhungana R.R. Dias da Silva D. Diaz D. Diaz L.A. Diaz M.J. Dima A. Ding D.D. Dinu M. Djalalinia S. Do T.C. Do T.H.P. do Prado C.B. Dodangeh M. Dohare S. Dokova K.G. Dong W. Dongarwar D. D’Oria M. Dorostkar F. Dorsey E.R. Doshi R. Doshmangir L. Dowou R.K. Driscoll T.R. Dsouza A.C. Dsouza H.L. Dumith S.C. Duncan B.B. Duraes A.R. Duraisamy S. Dushpanova A. Dzianach P.A. Dziedzic A.M. Ebrahimi A. Echieh C.P. Ed-Dra A. Edinur H.A. Edvardsson D. Edvardsson K. Efendi F. Eftekharimehrabad A. Eini E. Ekholuenetale M. Ekundayo T.C. El Arab R.A. El Sayed Zaki M. El-Dahiyat F. Elemam N.M. Elgar F.J. ElGohary G.M.T. Elhabashy H.R. Elhadi M. Elmehrath A.O. Elmeligy O.A.A. Elshaer M. Elsohaby I. Emeto T.I. Esfandiari N. Eshrati B. Eslami M. Esmaeili S.V. Estep K. Etaee F. Fabin N. Fagbamigbe A.F. Fagbule O.F. Fahimi S. Falzone L. Fareed M. Farinha C.S.S. Faris M.A.I.E.M. Faris P.S. Faro A. Fasina F.O. Fatehizadeh A. Fauk N.K. Fazylov T. Feigin V.L. Feng X. Fereshtehnejad S-M. Feroze A.H. Ferrara P. Ferrari A.J. Ferreira N. Fetensa G. Feyisa B.R. Filip I. Fischer F. Fitriana I. Flavel J. Flohr C. Flood D. Flor L.S. Foigt N.A. Folayan M.O. Force L.M. Fortuna D. Foschi M. Franklin R.C. Freitas A. Friedman S.D. Fux B. G S. Gaal P.A. Gaihre S. Gajdács M. Galali Y. Gallus S. Gandhi A.P. Ganesan B. Ganiyani M.A. Garcia V. Gardner W.M. Garg R.K. Gautam R.K. Gebi T.G. Gebregergis M.W. Gebrehiwot M. Gebremariam T.B.B. Gebremeskel T.G. Gerema U. Getacher L. Getahun G.K. Getie M. Ghadirian F. Ghafarian S. Ghaffari Jolfayi A. Ghailan K.Y. Ghajar A. Ghasemi M.R. Ghasempour Dabaghi G. Ghasemzadeh A. Ghassemi F. Ghazy R.M. Gholami A. Gholamrezanezhad A. Gholizadeh N. Ghorbani M. Gil A.U. Gil G.F. Gilbertson N.M. Gill P.S. Gill T.K. Gindaba E.Z. Girmay A. Glasbey J.C. Gnedovskaya E.V. Göbölös L. Godinho M.A. Goel A. Golechha M. Goleij P. Golinelli D. Gomes N.G.M. Gopalani S.V. Gorini G. Goudarzi H. Goulart A.C. Gouravani M. Goyal A. Graham S.M. Grivna M. Grosso G. Guan S-Y. Guarducci G. Gubari M.I.M. Guha A. Guicciardi S. Gulati S. Gulisashvili D. Gunawardane D.A. Guo C. Gupta A.K. Gupta B. Gupta M. Gupta R. Gupta R.D. Gupta R. Gupta S. Gupta V.B. Gupta V.K. Gupta V.K. Habibzadeh F. Habibzadeh P. Hadaro T.S. Hadian Z. Haep N. Haghi-Aminjan H. Haghmorad D. Hagins H. Haile D. Hailu A. Hajj Ali A. Halboub E.S. Halimi A. Hall B.J. Haller S. Halwani R. Hamadeh R.R. Hamdy N.M. Hameed S. Hamidi S. Hammoud A. Hanif A. Hanifi N. Haq Z.A. Haque M.R. Harapan H. Hargono A. Haro J.M. Hasaballah A.I. Hasan I. Hasan M.J. Hasan S.M.M. Hasani H. Hasanian M. Hashmeh N. Hasnain M.S. Hassan A. Hassan I. Hassan Zadeh Tabatabaei M.S. Hassani S. Hassanipour S. Hassankhani H. Haubold J. Havmoeller R.J. Hay S.I. Hebert J.J. Hegazi O.E. Hegena T.Y. Heidari G. Heidari M. Helfer B. Hemmati M. Henson C.A. Herbert M.E. Herteliu C. Heuer A. Hezam K. Hinneh T.K. Hiraike Y. Hoan N.Q. Holla R. Hon J. Hoque M.E. Horita N. Hossain S. Hosseini S.E. Hosseinzadeh H. Hosseinzadeh M. Hostiuc M. Hostiuc S. Hoven H. Hsairi M. Hsu J.M. Hu C. Huang J. Huda M.N. Hulland E.N. Hultström M. Hushmandi K. Hussain J. Hussein N.R. Huynh C.K. Huynh H-H. Ibitoye S.E. Idowu O.O. Ihler A.L. Ikeda N. Ikuta K.S. Ilesanmi O.S. Ilic I.M. Ilic M.D. Imam M.T. Immurana M. Inbaraj L.R. Irham L.M. Isa M.A. Islam M.R. Ismail F. Ismail N.E. Iso H. Isola G. Iwagami M. Iwu C.C.D. Iwu-Jaja C.J. J V. Jaafari J. Jacob L. Jacobsen K.H. Jadidi-Niaragh F. Jahankhani K. Jahanmehr N. Jahrami H. Jain A. Jain N. Jairoun A.A. Jaiswal A. Jakovljevic M. Jalilzadeh Yengejeh R. Jamora R.D.G. Jatau A.I. Javadov S. Javaheri T. Jayaram S. Jeganathan J. Jeswani B.M. Jiang H. Johnson C.O. Jokar M. Jomehzadeh N. Jonas J.B. Joo T. Joseph A. Joseph N. Joshi V. Joshua C.E. Jozwiak J.J. Jürisson M. Kaambwa B. Kabir A. Kabir Z. Kadashetti V. Kahn E.M. Kalani R. Kaliyadan F. Kalra S. Kamath R. Kanagasabai T. Kanchan T. Kandel H. Kanmiki E.W. Kanmodi K.K. Kansal S.K. Kapner D.J. Kapoor N. Karagiannidis E. Karajizadeh M. Karakasis P. Karanth S.D. Karaye I.M. Karch A. Karim A. Karimi H. Karmakar S. Kashoo F.Z. Kasraei H. Kassahun W.D. Kassebaum N.J. Kassel M.B. Katikireddi S.V. Kauppila J.H. Kawakami N. Kaydi N. Kayode G.A. Kazemi F. Keiyoro P.N. Kemmer L. Kempen J.H. Kerr J.A. Kesse-Guyot E. Khader Y.S. Khafaie M.A. Khajuria H. Khalaji A. Khalil M. Khalilian A. Khamesipour F. Khan A. Khan M.N. Khan M. Khan M.J. Khan M.A.B. Khanmohammadi S. Khatab K. Khatatbeh H. Khatatbeh M.M. Khatib M.N. Khavandegar A. Khayat Kashani H.R. Khidri F.F. Khodadoust E. Khormali M. Khorrami Z. Khosla A.A. Khosrowjerdi M. Khreis H. Khusun H. Kifle Z.D. Kim K. Kim M.S. Kim Y.J. Kimokoti R.W. Kisa A. Kisa S. Knibbs L.D. Knudsen A.K.S. Koh D.S.Q. Kolahi A-A. Kompani F. Kong J. Koren G. Korja M. Korshunov V.A. Korzh O. Kosen S. Kothari N. Koul P.A. Koulmane Laxminarayana S.L. Krishan K. Krishnamoorthy V. Krishnamoorthy Y. Krishnan B. Krohn K.J. Kuate Defo B. Kucuk Bicer B. Kuddus M.A. Kuddus M. Kugbey N. Kuitunen I. Kulimbet M. Kulkarni V. Kumar A. Kumar N. Kumar V. Kundu S. Kurmi O.P. Kusnali A. Kusuma D. Kutluk T. La Vecchia C. Ladan M.A. Laflamme L. Lahariya C. Lai D.T.C. Lal D.K. Lallukka T. Lám J. Lan Q. Lan T. Landires I. Lanfranchi F. Langguth B. Lansingh V.C. Laplante-Lévesque A. Larijani B. Larsson A.O. Lasrado S. Lauriola P. Le H-H. Le L.K.D. Le N.H.H. Le T.T.T. Leasher J.L. Ledda C. Lee M. Lee P.H. Lee S.W. Lee S.W.H. Lee Y.H. LeGrand K.E. Leigh J. Leong E. Lerango T.L. Lescinsky H. Leung J. Li M-C. Li W-Z. Li W. Li Y. Li Z. Ligade V.S. Lim L-L. Lim S.S. Lin R-T. Lin S. Liu C. Liu G. Liu J. Liu J. Liu R.T. Liu S. Liu W. Liu X. Liu X. Livingstone K.M. Llanaj E. Lohiya A. López-Bueno R. Lopukhov P.D. Lorkowski S. Lotufo P.A. Lozano R. Lubinda J. Lucchetti G. Luo L. lv H. M Amin H.I. Ma Z.F. Maass K.L. Mabrok M. Machairas N. Machoy M. Mafhoumi A. Magdy Abd El Razek M. Maghazachi A.A. Mahadeshwara Prasad D.R. Maharaj S.B. Mahmoud M.A. Mahmoudi E. Majeed A. Makram O.M. Makris K.C. Malasala S. Maled V. Malhotra K. Malik A.A. Malik I. Malinga L.A. Malta D.C. Mamun A.A. Manda A.L. Manla Y. Mansour A. Mansouri B. Mansouri P. Mansourian M. Mansournia M.A. Mantovani L.G. Manu E. Marateb H.R. Maravilla J.C. Marsh E. Martinez G. Martinez-Piedra R. Martini S. Martins-Melo F.R. Martorell M. Marx W. Maryam S. Mathangasinghe Y. Mathioudakis A.G. Matozinhos F.P. Mattumpuram J. Maugeri A. Maulik P.K. Mayeli M. Mazidi M. Mazzotti A. McGrath J.J. McKee M. McKowen A.L.W. McLaughlin S.A. McPhail M.A. McPhail S.M. Mechili E.A. Mehmood A. Mehmood K. Mehrabani-Zeinabad K. Mehrabi Nasab E. Meier T. Mejia-Rodriguez F. Mekene Meto T. Mekonnen B.D. Menezes R.G. Mengist B. Mensah G.A. Mensah L.G. Mentis A-F.A. Meo S.A. Meretoja A. Meretoja T.J. Mersha A.M. Mesfin B.A. Mestrovic T. Mettananda K.C.D. Mettananda S. Miazgowski T. Micha G. Michalek I.M. Micheletti Gomide Nogueira de Sá A.C. Miller T.R. Mirarefin M. Mirghafourvand M. Mirica A. Mirijello A. Mirrakhimov E.M. Mirshahi A. Mirzaei M. Mishra A.K. Mishra V. Mitchell P.B. Mithra P. Mittal C. Moazen B. Moberg M.E. Mocciaro G. Mohamadkhani A. Mohamed A.Z. Mohamed A.I. Mohamed J. Mohamed M.F.H. Mohamed N.S. Mohammadi E. Mohammadi S. Mohammadian-Hafshejani A. Mohammadifard N. Mohammed H. Mohammed M. Mohammed S. Mohammed S. Mokdad A.H. Monasta L. Mondello S. Moni M.A. Moodi Ghalibaf A.A. Moore C.E. Moradi M. Moradi Y. Moraga P. Morawska L. Moreira R.S. Morovatdar N. Morrison S.D. Morze J. Mosaddeghi Heris R. Mossialos E. Motappa R. Mougin V. Mousavi P. Msherghi A. Mubarik S. Muccioli L. Mueller U.O. Mulita F. Mullany E.C. Munjal K. Murillo-Zamora E. Murlimanju B.V. Musina A-M. Mustafa G. Muthu S. Muthupandian S. Muthusamy R. Muzaffar M. Myung W. Nafei A. Nagarajan A.J. Nagaraju S.P. Nagel G. Naghavi M. Naghavi P. Naik G.R. Naik G. Nainu F. Nair T.S. Najdaghi S. Nakhostin Ansari N. Nanavaty D.P. Nangia V. Narasimha Swamy S. Narimani Davani D. Nascimento B.R. Nascimento G.G. Nashwan A.J. Natto Z.S. Nauman J. Navaratna S.N.K. Naveed M. Nayak B.P. Nayak V.C. Ndejjo R. Nduaguba S.O. Negash H. Negoi I. Negoi R.I. Nejadghaderi S.A. Nejjari C. Nematollahi M.H. Nepal S. Neupane S. Ng M. Nguefack-Tsague G. Ngunjiri J.W. Nguyen D.H. Nguyen N.N.Y. Nguyen P.T. Nguyen P.T. Nguyen V.T. Nguyen Tran Minh D. Niazi R.K. Nicholson S.I. Nie J. Nikoobar A. Nikpoor A.R. Ningrum D.N.A. Nnaji C.A. Noman E.A. Nomura S. Noroozi N. Norrving B. Noubiap J.J. Nri-Ezedi C.A. Ntaios G. Ntsekhe M. Nunemo M.H. Nurrika D. Nutor J.J. Oancea B. O’Connell E.M. Odetokun I.A. O’Donnell M.J. Oduro M.S. Ogunfowokan A.A. Ogunkoya A. Oh I-H. Okati-Aliabad H. Okeke S.R. Okekunle A.P. Okonji O.C. Olagunju A.T. Olasupo O.O. Olatubi M.I. Oliveira A.B. Oliveira G.M.M. Olorukooba A.A. Olufadewa I.I. Olusanya B.O. Olusanya J.O. Oluwafemi Y.D. Omar H.A. Omar Bali A. Omer G.L. Ong K.L. Ong S. Onwujekwe O.E. Onyedibe K.I. Oppong A.F. Ordak M. Orish V.N. Ornello R. Orpana H.M. Ortiz A. Ortiz-Prado E. Osman W.M.S. Ostroff S.M. Osuagwu U.L. Otoiu A. Otstavnov N. Otstavnov S.S. Ouyahia A. Owolabi M.O. Oyeyemi I.T. Oyeyemi O.T. P A M.P. Pacheco-Barrios K. Padron-Monedero A. Padubidri J.R. Pal P.K. Palicz T. Pan F. Pan H-F. Pana A. Panda S.K. Panda-Jonas S. Pandey A. Pandi-Perumal S.R. Pangaribuan H.U. Pantazopoulos I. Pantea Stoian A.M. Papadopoulou P. Parent M.C. Parija P.P. Parikh R.R. Park S. Park S. Parsons N. Pashaei A. Pasovic M. Passera R. Patil S. Patoulias D. Patthipati V.S. Paudel U. Pawar S. Pazoki Toroudi H. Peden A.E. Pedersini P. Peng M. Pensato U. Pepito V.C.F. Peprah E.K. Peprah P. Peres M.F.P. Perianayagam A. Perico N. Perna S. Pesudovs K. Petcu I-R. Petermann-Rocha F.E. Pham H.T. Philip A.K. Phillips M.R. Pickering B.V. Pierannunzio D. Pigeolet M. Pigott D.M. Piracha Z.Z. Piradov M.A. Pisoni E. Piyasena M.P. Plass D. Plotnikov E. Poddighe D. Polkinghorne K.R. Poluru R. Pond C.D. Popovic D.S. Porru F. Postma M.J. Poudel G.R. Pour-Rashidi A. Pourshams A. Pourtaheri N. Prabhu D. Prada S.I. Pradhan J. Pradhan P.M.S. Prasad M. Prates E.J.S. Purnobasuki H. Purohit B.M. Puvvula J. Qasim N.H. Qattea I. Qazi A.S. Qian G. Qiu S. Rabiee Rad M. Radfar A. Radhakrishnan R.A. Radhakrishnan V. Raeisi Shahraki H. Rafferty Q. Rafiei A. Raggi A. Raghav P.R. Raheem N. Rahim F. Rahim M.J. Rahimifard M. Rahimi-Movaghar V. Rahman M.O. Rahman M.A. Rahmani A.M. Rahmani B. Rahmanian M. Rahmanian N. Rahmanian V. Rahmati M. Rahmawaty S. Raimondo D. Rajaa S. Rajendran V. Rajput P. Ramadan M.M. Ramasamy S.K. Ramasubramani P. Ramazanu S. Ramteke P.W. Rana J. Rana K. Ranabhat C.L. Rane A. Rani U. Ranta A. Rao C.R. Rao M. Rao P.C. Rao S.J. Rasella D. Rashedi S. Rashedi V. Rashidi M. Rashidi M-M. Rasouli-Saravani A. Ratan Z.A. Rathnaiah Babu G. Rauniyar S.K. Rautalin I. Rawaf D.L. Rawaf S. Rawassizadeh R. Razo C. Reda Z.F.F. Reddy M.M.R.K. Redwan E.M.M. Reifels L. Reitsma M.B. Remuzzi G. Reshmi B. Resnikoff S. Restaino S. Reyes L.F. Rezaei M. Rezaei N. Rezaei N. Rezaeian M. Rhee T.G. Riaz M.A. Ribeiro A.L.P. Rickard J. Robinson-Oden H.E. Rodrigues C.F. Rodrigues M. Rodriguez J.A.B. Roever L. Romadlon D.S. Ronfani L. Rosauer J.J. Roshandel G. Rostamian M. Rotimi K. Rout H.S. Roy B. Roy N. Rubagotti E. Ruela G.A. Rumisha S.F. Runghien T. Russo M. Ruzzante S.W. S N C. Saad A.M.A. Saber K. Saber-Ayad M.M. Sabour S. Sacco S. Sachdev P.S. Sachdeva R. Saddik B. Saddler A. Sadee B.A. Sadeghi E. Sadeghi M. Sadeghi Majd E. Saeb M.R. Saeed U. Safari M. Safi S. Safi S.Z. Sagar R. Sagoe D. Saheb Sharif-Askari F. Saheb Sharif-Askari N. Sahebkar A. Sahoo S.S. Sahu M. Saif Z. Sajid M.R. Sakshaug J.W. Salam N. Salamati P. Salami A.A. Salaroli L.B. Salehi L. Salehi S. Salem M.R. Salem M.Z.Y. Salihu D. Salimi S. Salum G.A. Samadi Kafil H. Samadzadeh S. Samodra Y.L. Samuel V.P. Samy A.M. Sanabria J. Sanjeev R.K. Sanna F. Santomauro D.F. Santric-Milicevic M.M. Sarasmita M.A. Saraswathy S.Y.I. Saravanan A. Saravi B. Sarikhani Y. Sarmiento-Suárez R. Sarode G.S. Sarode S.C. Sartorius B. Sarveazad A. Sathian B. Sattin D. Sawhney M. Saya G.K. Sayeed A. Sayeed M.A. Sayyah M. Schinckus C. Schmidt M.I. Schuermans A. Schumacher A.E. Schutte A.E. Schwarzinger M. Schwebel D.C. Schwendicke F. Selvaraj S. Semreen M.H. Senthilkumaran S. Serban D. Serre M.L. Sethi Y. Shafie M. Shah H. Shah N.S. Shah P.A. Shah S.M. Shahbandi A. Shaheen A.A. Shahid S. Shahid W. Shahsavari H.R. Shahwan M.J. Shaikh M.A. Shaikh S.Z. Shalash A.S. Sham S. Shamim M.A. Shams-Beyranvand M. Shamshirgaran M.A. Shamsi M.A. Shanawaz M. Shankar A. Sharfaei S. Sharifan A. Sharifi-Rad J. Sharma M. Sharma U. Sharma V. Shastry R.P. Shavandi A. Shehabeldine A.M.E. Shehzadi S. Sheikh A. Shen J. Shetty A. Shetty B.S.K. Shetty P.H. Shiani A. Shiferaw D. Shigematsu M. Shin M-J. Shiri R. Shittu A. Shiue I. Shivakumar K.M. Shivarov V. Shool S. Shorofi S.A. Shrestha R. Shrestha S. Shuja K.H. Shuval K. Si Y. Siddig E.E. Silva D.A.S. Silva L.M.L.R. Silva S. Silva T.P.R. Simpson C.R. Singh A. Singh B.B. Singh B. Singh G. Singh H. Singh J.A. Singh M. Singh N.P. Singh P. Singh S. Sinto R. Sivakumar S. Siwal S.S. Skhvitaridze N. Skou S.T. Sleet D.A. Sobia F. Soboka M. Socea B. Solaimanian S. Solanki R. Solanki S. Soliman S.S.M. Somayaji R. Song Y. Sorensen R.J.D. Soriano J.B. Soyiri I.N. Spartalis M. Spearman S. Spencer C.N. Sreeramareddy C.T. Stachteas P. Stafford L.K. Stanaway J.D. Stanikzai M.H. Stein C. Stein D.J. Steinbeis F. Steiner C. Steinke S. Steiropoulos P. Stockfelt L. Stokes M.A. Straif K. Stranges S. Subedi N. Subramaniyan V. Suleman M. Suliankatchi Abdulkader R. Sundström J. Sunkersing D. Sunnerhagen K.S. Suresh V. Swain C.K. Szarpak L. Szeto M.D. Tabaee Damavandi P. Tabarés-Seisdedos R. Tabatabaei S.M. Tabatabaei Malazy O. Tabatabaeizadeh S-A. Tabatabai S. Tabche C. Tabish M. Tadakamadla S.K. Taheri Abkenar Y. Taheri Soodejani M. Taherkhani A. Taiba J. Takahashi K. Talaat I.M. Tamuzi J.L. Tan K-K. Tang H. Tat N.Y. Taveira N. Tefera Y.M. Tehrani-Banihashemi A. Temesgen W.A. Temsah M-H. Teramoto M. Terefa D.R. Teye-Kwadjo E. Thakur R. Thangaraju P. Thankappan K.R. Thapar R. Thayakaran R. Thirunavukkarasu S. Thomas N. Thomas N.K. Tian J. Tichopad A. Ticoalu J.H.V. Tiruye T.Y. Tobe-Gai R. Tolani M.A. Tolossa T. Tonelli M. Topor-Madry R. Topouzis F. Touvier M. Tovani-Palone M.R. Trabelsi K. Tran J.T. Tran M.T.N. Tran N.M. Trico D. Trihandini I. Troeger C.E. Tromans S.J. Truyen T.T.T.T. Tsatsakis A. Tsermpini E.E. Tumurkhuu M. Udoakang A.J. Udoh A. Ullah A. Ullah S. Ullah S. Umair M. Umakanthan S. Unim B. Unnikrishnan B. Upadhyay E. Urso D. Usman J.S. Vaithinathan A.G. Vakili O. Valenti M. Valizadeh R. Van den Eynde J. van Donkelaar A. Varga O. Vart P. Varthya S.B. Vasankari T.J. Vasic M. Vaziri S. Venketasubramanian N. Verghese N.A. Verma M. Veroux M. Verras G-I. Vervoort D. Villafañe J.H. Villalobos-Daniel V.E. Villani L. Villanueva G.I. Vinayak M. Violante F.S. Vlassov V. Vo B. Vollset S.E. Volovat S.R. Vos T. Vujcic I.S. Waheed Y. Wang C. Wang F. Wang S. Wang Y. Wang Y-P. Wanjau M.N. Waqas M. Ward P. Waris A. Wassie E.G. Weerakoon K.G. Weintraub R.G. Weiss D.J. Weiss E.J. Weldetinsaa H.L.L. Wells K.M. Wen Y.F. Wiangkham T. Wickramasinghe N.D. Wilkerson C. Willeit P. Wilson S. Wong Y.J. Wongsin U. Wozniak S. Wu C. Wu D. Wu F. Wu Z. Xia J. Xiao H. Xu S. Xu X. Xu Y.Y. Yadav M.K. Yaghoubi S. Yamagishi K. Yang L. Yano Y. Yaribeygi H. Yasufuku Y. Ye P. Yesodharan R. Yesuf S.A. Yezli S. Yi S. Yiğit A. Yigzaw Z.A. Yin D. Yip P. Yismaw M.B. Yon D.K. Yonemoto N. You Y. Younis M.Z. Yousefi Z. Yu C. Yu Y. Zadey S. Zadnik V. Zakham F. Zaki N. Zakzuk J. Zamagni G. Zaman S.B. Zandieh G.G.Z. Zanghì A. Zar H.J. Zare I. Zarimeidani F. Zastrozhin M.S. Zeng Y. Zhai C. Zhang A.L. Zhang H. Zhang L. Zhang M. Zhang Y. Zhang Z. Zhang Z-J. Zhao H. Zhao J.T. Zhao X-J.G. Zhao Y. Zhao Y. Zhong C. Zhou J. Zhou J. Zhou S. Zhu B. Zhu L. Zhu Z. Ziaeian B. Ziafati M. Zielińska M. Zimsen S.R.M. Zoghi G. Zoller T. Zumla A. Zyoud S.H. Zyoud S.H. Murray C.J.L. Gakidou E. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: A systematic analysis for the global burden of disease study 2021. Lancet 2024 403 10440 2162 2203 10.1016/S0140‑6736(24)00933‑4 38762324
    [Google Scholar]
  3. Nadeem H.M.R. Mohiuddin E. UdDin S. Daniyal M. Usmanghani K. Comparison of anti BPH capsule (herbal) and Terazosin HCl in the treatment of benign prostate hyperplasia. Pak. J. Pharm. Sci. 2017 30 1 Suppl. 289 293 28625956
    [Google Scholar]
  4. Kyei M.Y. Mensah J.E. Morton B. Gepi-Attee S. Klufio G.O. Yeboah E.D. Surgical management of BPH in Ghana: A need to improve access to transurethral resection of the prostate. East Afr. Med. J. 2012 89 7 241 245 26845803
    [Google Scholar]
  5. Kyei M.Y. Klufio G.O. Ayamba A. Mohammed S. Traditional medicines and alternative practice in the management of prostate diseases in southern Ghana. Ghana Med. J. 2017 51 3 128 137 10.4314/gmj.v51i3.6 29622824
    [Google Scholar]
  6. Azzouni F. Godoy A. Li Y. Mohler J. The 5 alpha-reductase isozyme family: A review of basic biology and their role in human diseases. Adv. Urol. 2012 2012 1 1 18 10.1155/2012/530121 22235201
    [Google Scholar]
  7. Chughtai B. Forde J.C. Thomas D.D.M. Laor L. Hossack T. Woo H.H. Te A.E. Kaplan S.A. Benign prostatic hyperplasia. Nat. Rev. Dis. Primers 2016 2 1 16031 10.1038/nrdp.2016.31 27147135
    [Google Scholar]
  8. Foo K.T. What is a disease? What is the disease clinical benign prostatic hyperplasia (BPH)? World J. Urol. 2019 37 7 1293 1296 10.1007/s00345‑019‑02691‑0 30805683
    [Google Scholar]
  9. Gandhi J. Weissbart S.J. Smith N.L. Kaplan S.A. Dagur G. Zumbo A. Joshi G. Khan S.A. The impact and management of sexual dysfunction secondary to pharmacological therapy of benign prostatic hyperplasia. Transl. Androl. Urol. 2017 6 2 295 304 10.21037/tau.2017.03.57 28540239
    [Google Scholar]
  10. Liu F.C. Hua K.C. Lin J.R. Pang S.T. Yu H.P. Prostate resected weight and postoperative prostate cancer incidence after transurethral resection of the prostate. Medicine 2019 98 3 e13897 10.1097/MD.0000000000013897 30653095
    [Google Scholar]
  11. Nickel J.C. Chughtai B. De Nunzio C. Brahmbhatt J. Shore N. Te A.E. Djavan B. Rethinking the role of saw palmetto extract for men with lower urinary tract symptoms in North America. Uro 2022 2 3 137 150 10.3390/uro2030017
    [Google Scholar]
  12. Lowe F.C. Ku J.C. Phytotherapy in treatment of benign prostatic hyperplasia: A critical review. Urology 1996 48 1 12 20 10.1016/S0090‑4295(96)00077‑5 8693632
    [Google Scholar]
  13. Antoniou V. Gauhar V. Modi S. Somani B.K. Role of phytotherapy in the management of BPH: A summary of the literature. J. Clin. Med. 2023 12 5 1899 10.3390/jcm12051899 36902686
    [Google Scholar]
  14. Roehrborn C.G. Schwinn D.A. α1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. J. Urol. 2004 171 3 1029 1035 10.1097/01.ju.0000097026.43866.cc 14767264
    [Google Scholar]
  15. Zaman Huri H. Hui Xin C. Sulaiman C.Z. Drug-related problems in patients with benign prostatic hyperplasia: A cross sectional retrospective study. PLoS One 2014 9 1 e86215 10.1371/journal.pone.0086215 24475089
    [Google Scholar]
  16. Shao W.H. Zheng C.F. Ge Y.C. Chen X.R. Zhang B.W. Wang G.L. Zhang W.D. Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older. Asian J. Androl. 2023 25 1 132 136 10.4103/aja202223 35532557
    [Google Scholar]
  17. Abdelmoteleb H. Jefferies E.R. Drake M.J. Assessment and management of male lower urinary tract symptoms (LUTS). Int. J. Surg. 2016 25 164 171 10.1016/j.ijsu.2015.11.043 26654899
    [Google Scholar]
  18. Gacci M. Corona G. Vignozzi L. Salvi M. Serni S. De Nunzio C. Tubaro A. Oelke M. Carini M. Maggi M. Metabolic syndrome and benign prostatic enlargement: A systematic review and meta-analysis. BJU Int. 2015 115 1 24 31 10.1111/bju.12728 24602293
    [Google Scholar]
  19. Andriole G.L. Roehrborn C. Schulman C. Slawin K.M. Somerville M. Rittmaster R.S. Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia. Urology 2004 64 3 537 541 10.1016/j.urology.2004.04.084 15351586
    [Google Scholar]
  20. Mirgh D. Sonar S. Ghosh S. Adhikari M.D. Subramaniyan V. Gorai S. Anand K. Landscape of exosomes to modified exosomes: A state of the art in cancer therapy. RSC Advances 2024 14 42 30807 30829 10.1039/D4RA04512B 39328877
    [Google Scholar]
  21. Bhat A.A. Afzal M. Moglad E. Thapa R. Ali H. Almalki W.H. Kazmi I. Alzarea S.I. Gupta G. Subramaniyan V. lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer. Clin. Exp. Med. 2024 24 1 226 10.1007/s10238‑024‑01491‑0 39325172
    [Google Scholar]
  22. Krishnamoorthi R. Ganapathy A A. Hari Priya V.M. Kumaran A. Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia. J. Ethnopharmacol. 2024 330 118207 10.1016/j.jep.2024.118207 38636573
    [Google Scholar]
  23. Bartsch G. Rittmaster R.S. Klocker H. Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia. Eur. Urol. 2000 37 4 367 380 10.1159/000020181 10765065
    [Google Scholar]
  24. Lee C.L. Kuo H.C. Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: Current concepts. Tzu-Chi Med. J. 2017 29 2 79 83 10.4103/tcmj.tcmj_20_17 28757771
    [Google Scholar]
  25. Briganti A. Capitanio U. Suardi N. Gallina A. Salonia A. Bianchi M. Tutolo M. Di Girolamo V. Guazzoni G. Rigatti P. Montorsi F. Benign prostatic hyperplasia and its aetiologies. Eur. Urol. Suppl. 2009 8 13 865 871 10.1016/j.eursup.2009.11.002
    [Google Scholar]
  26. Krušlin B. Tomas D. Džombeta T. Milković-Periša M. Ulamec M. Inflammation in prostatic hyperplasia and carcinoma—basic scientific approach. Front. Oncol. 2017 7 77 10.3389/fonc.2017.00077 28487844
    [Google Scholar]
  27. Yassin A. Nettleship J.E. Talib R.A. Almehmadi Y. Doros G. Effects of testosterone replacement therapy withdrawal and re-treatment in hypogonadal elderly men upon obesity, voiding function and prostate safety parameters. Aging Male 2016 19 1 64 69 10.3109/13685538.2015.1126573 26742589
    [Google Scholar]
  28. Kelly D.M. Jones T.H. Testosterone and obesity. Obes. Rev. 2015 16 7 581 606 10.1111/obr.12282 25982085
    [Google Scholar]
  29. De Nunzio C. Kramer G. Marberger M. Montironi R. Nelson W. Schröder F. Sciarra A. Tubaro A. The controversial relationship between benign prostatic hyperplasia and prostate cancer: The role of inflammation. Eur. Urol. 2011 60 1 106 117 10.1016/j.eururo.2011.03.055 21497433
    [Google Scholar]
  30. Qi J. Huang H-F. Wu Y. Pan H. Wang W-M. Xu D. Zhang L. Gu Z-Q. Bai Q. A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection. Asian J. Androl. 2017 19 2 230 233 10.4103/1008‑682X.171575 26763548
    [Google Scholar]
  31. Wang Z. Olumi A.F. Diabetes, growth hormone-insulin-like growth factor pathways and association to benign prostatic hyperplasia. Differentiation 2011 82 4-5 261 271 10.1016/j.diff.2011.04.004 21536370
    [Google Scholar]
  32. Minutoli L. Rinaldi M. Marini H. Irrera N. Crea G. Lorenzini C. Puzzolo D. Valenti A. Pisani A. Adamo E. Altavilla D. Squadrito F. Micali A. Apoptotic pathways linked to endocrine system as potential therapeutic targets for benign prostatic hyperplasia. Int. J. Mol. Sci. 2016 17 8 1311 10.3390/ijms17081311 27529214
    [Google Scholar]
  33. Boyle P. Lawrence Gould A. Roehrborn C.G. Prostate volume predicts outcome of treatment of benign prostatic hyperplasia with finasteride: Meta-analysis of randomized clinical trials. Urology 1996 48 3 398 405 10.1016/S0090‑4295(96)00353‑6 8804493
    [Google Scholar]
  34. Hennenberg M. Schreiber A. Ciotkowska A. Rutz B. Waidelich R. Strittmatter F. Stief C.G. Gratzke C. Cooperative effects of EGF, FGF, and TGF-β1 in prostate stromal cells are different from responses to single growth factors. Life Sci. 2015 123 18 24 10.1016/j.lfs.2014.12.006 25529149
    [Google Scholar]
  35. Dinçel Ç. Çaşkurlu T. Taşçi A.I. Çek M. Sevin G. Fazlioğlu A. Prospective evaluation of prostate specific antigen (PSA), PSA density, free-to-total PSA ratio and a new formula (prostate malignancy index) for detecting prostate cancer and preventing negative biopsies in patients with normal rectal examinations and intermediate PSA levels. Int. Urol. Nephrol. 1999 31 4 497 509 10.1023/A:1007167328877 10668945
    [Google Scholar]
  36. Carter H.B. Pearson J.D. PSA velocity for the diagnosis of early prostate cancer. A new concept. Urol. Clin. North Am. 1993 20 4 665 670 10.1016/S0094‑0143(21)00919‑8 7505974
    [Google Scholar]
  37. Catalona W.J. Partin A.W. Slawin K.M. Brawer M.K. Flanigan R.C. Patel A. Richie J.P. deKernion J.B. Walsh P.C. Scardino P.T. Lange P.H. Subong E.N.P. Parson R.E. Gasior G.H. Loveland K.G. Southwick P.C. Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: A prospective multicenter clinical trial. JAMA 1998 279 19 1542 1547 10.1001/jama.279.19.1542 9605898
    [Google Scholar]
  38. Draisma G. Boer R. Otto S.J. van der Cruijsen I.W. Damhuis R.A.M. Schröder F.H. de Koning H.J. Lead times and overdetection due to prostate-specific antigen screening: Estimates from the european randomized study of screening for prostate cancer. J. Natl. Cancer Inst. 2003 95 12 868 878 10.1093/jnci/95.12.868 12813170
    [Google Scholar]
  39. Partin A.W. Catalona W.J. Southwick P.C. Subong E.N.P. Gasior G.H. Chan D.W. Analysis of percent free prostate-specific antigen (PSA) for prostate cancer detection: Influence of total psa, prostate volume, and age. Urology 1996 48 6 Suppl. 55 61 10.1016/S0090‑4295(96)00611‑5 8973701
    [Google Scholar]
  40. Sokoll L.J. Sanda M.G. Feng Z. Kagan J. Mizrahi I.A. Broyles D.L. Partin A.W. Srivastava S. Thompson I.M. Wei J.T. Zhang Z. Chan D.W. A prospective, multicenter, national cancer institute early detection research network study of [-2]proPSA: Improving prostate cancer detection and correlating with cancer aggressiveness. Cancer Epidemiol. Biomarkers Prev. 2010 19 5 1193 1200 10.1158/1055‑9965.EPI‑10‑0007 20447916
    [Google Scholar]
  41. Alberts A.R. Schoots I.G. Roobol M.J. Prostate‐specific antigen‐based prostate cancer screening: Past and future. Int. J. Urol. 2015 22 6 524 532 10.1111/iju.12750 25847604
    [Google Scholar]
  42. Williamson D.A. Barrett L.K. Rogers B.A. Freeman J.T. Hadway P. Paterson D.L. Infectious complications following transrectal ultrasound-guided prostate biopsy: New challenges in the era of multidrug-resistant Escherichia coli. Clin. Infect. Dis. 2013 57 2 267 274 10.1093/cid/cit193 23532481
    [Google Scholar]
  43. Philip J. McCabe J. Dutta Roy S. Samsudin A. Campbell I.M. Javlé P. Site of local anaesthesia in transrectal ultrasonography‐guided 12‐core prostate biopsy: Does it make a difference? BJU Int. 2006 97 2 263 265 10.1111/j.1464‑410X.2006.05957.x 16430625
    [Google Scholar]
  44. Nazir B. Pain during transrectal ultrasound-guided prostate biopsy and the role of periprostatic nerve block: What radiologists should know. Korean J. Radiol. 2014 15 5 543 553 10.3348/kjr.2014.15.5.543 25246816
    [Google Scholar]
  45. Lawrence E.M. Gallagher F.A. Barrett T. Warren A.Y. Priest A.N. Goldman D.A. Sala E. Gnanapragasam V.J. Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer. AJR Am. J. Roentgenol. 2014 203 3 W280 W286 10.2214/AJR.13.11754 25148185
    [Google Scholar]
  46. Hoeks C.M.A. Barentsz J.O. Hambrock T. Yakar D. Somford D.M. Heijmink S.W.T.P.J. Scheenen T.W.J. Vos P.C. Huisman H. van Oort I.M. Witjes J.A. Heerschap A. Fütterer J.J. Prostate cancer: Multiparametric MR imaging for detection, localization, and staging. Radiology 2011 261 1 46 66 10.1148/radiol.11091822 21931141
    [Google Scholar]
  47. Heidenreich A. Consensus criteria for the use of magnetic resonance imaging in the diagnosis and staging of prostate cancer: not ready for routine use. Eur Urol. 2011 59 4 495 497 10.1016/j.eururo.2011.01.013
    [Google Scholar]
  48. Mathey LIP Benign prostatic hyperplasia: Epidemiology, pathophysiology, and clinical manifestations. Molecular Mechanisms in Cancer IntechOpen 2022
    [Google Scholar]
  49. Carrero-López V.M. Cózar-Olmo J.M. Miñana-López B. Benign prostatic hyperplasia and lower urinary tract symptoms. A review of current evidence. Actas Urol. Esp. 2016 40 5 288 294 10.1016/j.acuro.2015.12.008 26823069
    [Google Scholar]
  50. De Monte C. Carradori S. Granese A. Di Pierro G.B. Leonardo C. De Nunzio C. Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptoms. BMC Urol. 2014 14 1 63 10.1186/1471‑2490‑14‑63 25112532
    [Google Scholar]
  51. Csikós E. Horváth A. Ács K. Papp N. Balázs V.L. Dolenc M.S. Kenda M. Kočevar Glavač N. Nagy M. Protti M. Mercolini L. Horváth G. Farkas Á. Treatment of benign prostatic hyperplasia by natural drugs. Molecules 2021 26 23 7141 10.3390/molecules26237141 34885733
    [Google Scholar]
  52. Lerner L.B. McVary K.T. Barry M.J. Bixler B.R. Dahm P. Das A.K. Gandhi M.C. Kaplan S.A. Kohler T.S. Martin L. Parsons J.K. Roehrborn C.G. Stoffel J.T. Welliver C. Wilt T.J. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA guideline part I—initial work-up and medical management. J. Urol. 2021 206 4 806 817 10.1097/JU.0000000000002183 34384237
    [Google Scholar]
  53. Haile E.S. Sotimehin A.E. Gill B.C. Medical management of benign prostatic hyperplasia. Cleve. Clin. J. Med. 2024 91 3 163 170 10.3949/ccjm.91a.23027 38429006
    [Google Scholar]
  54. Lepor H. Medical treatment of benign prostatic hyperplasia. Rev. Urol. 2011 13 1 20 33 21826125
    [Google Scholar]
  55. Mysore V. Shashikumar B.M. Guidelines on the use of finasteride in androgenetic alopecia. Indian J. Dermatol. Venereol. Leprol. 2016 82 2 128 134 10.4103/0378‑6323.177432 26924401
    [Google Scholar]
  56. Rittmaster R.S. 5α-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction. Best Pract. Res. Clin. Endocrinol. Metab. 2008 22 2 389 402 10.1016/j.beem.2008.01.016 18471794
    [Google Scholar]
  57. McConnell J.D. Roehrborn C.G. Bautista O.M. Andriole G.L. Jr Dixon C.M. Kusek J.W. Lepor H. McVary K.T. Nyberg L.M. Jr Clarke H.S. Crawford E.D. Diokno A. Foley J.P. Foster H.E. Jacobs S.C. Kaplan S.A. Kreder K.J. Lieber M.M. Lucia M.S. Miller G.J. Menon M. Milam D.F. Ramsdell J.W. Schenkman N.S. Slawin K.M. Smith J.A. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N. Engl. J. Med. 2003 349 25 2387 2398 10.1056/NEJMoa030656 14681504
    [Google Scholar]
  58. Wei J.T. Calhoun E. Jacobsen S.J. Urologic diseases in America project: Benign prostatic hyperplasia. J. Urol. 2005 173 4 1256 1261 10.1097/01.ju.0000155709.37840.fe 15758764
    [Google Scholar]
  59. Pirozzi L. Sountoulides P. Castellan P. Presicce F. Lombardo R. Romero M. Nunzio C. Tubaro A. Schips L. Cindolo L. Current pharmacological treatment for male LUTS due to BPH: Dutasteride or finasteride? Curr. Drug Targets 2015 16 11 1165 1171 10.2174/1389450116666150518101617 25981606
    [Google Scholar]
  60. Ahn H.S. Kim S.J. Choi J.B. Choo S.H. Shim K.H. Kim S.I. Long‐term cost comparison between surgical and medical therapy for benign prostatic hyperplasia: A study using hospital billing data. BJU Int. 2019 123 5A E79 E85 10.1111/bju.14584 30303597
    [Google Scholar]
  61. Reich O. Gratzke C. Stief C.G. Techniques and long-term results of surgical procedures for BPH. Eur. Urol. 2006 49 6 970 978 10.1016/j.eururo.2005.12.072 16481092
    [Google Scholar]
  62. Hueber P.A. Al-Asker A. Zorn K.C. Monopolar vs. bipolar TURP: Assessing their clinical advantages. Can. Urol. Assoc. J. 2011 5 6 390 391 10.5489/cuaj.11263 22154631
    [Google Scholar]
  63. Karadeniz M.S. Bayazit E. Aksoy O. Salviz E.A. Tefik T. Sanli O. Sungur M.O. Tugrul K.M. Bipolar versus monopolar resection of benign prostate hyperplasia: A comparison of plasma electrolytes, hemoglobin and TUR syndrome. Springerplus 2016 5 1 1739 10.1186/s40064‑016‑3407‑7 27777873
    [Google Scholar]
  64. Mamoulakis C. Ubbink D.T. de la Rosette J.J.M.C.H. Bipolar versus monopolar transurethral resection of the prostate: A systematic review and meta-analysis of randomized controlled trials. Eur. Urol. 2009 56 5 798 809 10.1016/j.eururo.2009.06.037 19595501
    [Google Scholar]
  65. Méndez-Probst C.E. Nott L. Pautler S.E. Razvi H. A multicentre single-blind randomized controlled trial comparing bipolar and monopolar transurethral resection of the prostate. Can. Urol. Assoc. J. 2011 5 6 385 389 10.5489/cuaj.10199 22154630
    [Google Scholar]
  66. Pavone C. Abbadessa D. Scaduto G. Caruana G. Scalici Gesolfo C. Fontana D. Vaccarella L. Sexual dysfunctions after transurethral resection of the prostate (TURP): Evidence from a retrospective study on 264 patients. Arch. Ital. Urol. Androl. 2015 87 1 8 13 10.4081/aiua.2015.1.8 25847889
    [Google Scholar]
  67. Rocco B. Albo G. Ferreira R.C. Spinelli M. Cozzi G. Dell’Orto P. Patel V. Rocco F. Recent advances in the surgical treatment of benign prostatic hyperplasia. Ther. Adv. Urol. 2011 3 6 263 272 10.1177/1756287211426301 22164196
    [Google Scholar]
  68. Braeckman J. Denis L. Management of BPH then 2000 and now 2016 – From BPH to BPO. Asian J. Urol. 2017 4 3 138 147 10.1016/j.ajur.2017.02.002 29264222
    [Google Scholar]
  69. Bhat S.A. Rather S.A. Islam N. An overview of benign prostatic hyperplasia and its appreciation in Greco-Arab (Unani) system of medicine. Asian J. Urol. 2022 9 2 109 118 10.1016/j.ajur.2021.05.008 35509487
    [Google Scholar]
  70. Shrivastava A. Gupta V. Various treatment options for benign prostatic hyperplasia: A current update. J Midlife Health 2012 3 1 10 19 10.4103/0976‑7800.98811 22923974
    [Google Scholar]
  71. Cicero A.F.G. Allkanjari O. Busetto G.M. Cai T. Larganà G. Magri V. Perletti G. Robustelli Della Cuna F.S. Russo G.I. Stamatiou K. Trinchieri A. Vitalone A. Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer. Arch. Ital. Urol. Androl. 2019 91 3 139 152 10.4081/aiua.2019.3.139 31577095
    [Google Scholar]
  72. Collins J.J. Phytotherapeutic management of endocrine dysfunctions. Nutrinews. 2006 8 1 1 8
    [Google Scholar]
  73. Edouard M.J. Miao L. Fan G.W. Ojong B.B.O. Zhen H. Zhang J. Gao X.M. Zhu Y. Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity. Chin. J. Nat. Med. 2014 12 5 321 334 10.1016/S1875‑5364(14)60040‑6 24856755
    [Google Scholar]
  74. Miernik A. Gratzke C. Current treatment for benign prostatic hyperplasia. Dtsch. Arztebl. Int. 2020 117 49 843 854 33593479
    [Google Scholar]
  75. Wu Y. Wichai N. Yang X. Ma Y. Suo T. Miao L. The role of phytoandrogens for benign prostatic hyperplasia treatment. Acupuncture and Herbal Medicine 2023 3 1 28 37 10.1097/HM9.0000000000000055
    [Google Scholar]
  76. Ong V.Y.C. Tan B.K.H. Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides. BMC Complement. Altern. Med. 2007 7 1 3 10.1186/1472‑6882‑7‑3 17261169
    [Google Scholar]
  77. Han Y. Huang W. Liu J. Liu D. Cui Y. Huang R. Yan J. Lei M. Triptolide inhibits the AR signaling pathway to suppress the proliferation of enzalutamide resistant prostate cancer cells. Theranostics 2017 7 7 1914 1927 10.7150/thno.17852 28638477
    [Google Scholar]
  78. Fujita R. Liu J. Shimizu K. Konishi F. Noda K. Kumamoto S. Ueda C. Tajiri H. Kaneko S. Suimi Y. Kondo R. Anti-androgenic activities of Ganoderma lucidum. J. Ethnopharmacol. 2005 102 1 107 112 10.1016/j.jep.2005.05.041 16029938
    [Google Scholar]
  79. Verma S. Singh S. Current and future status of herbal medicines. Vet. World 2008 2 2 347 10.5455/vetworld.2008.347‑350
    [Google Scholar]
  80. Dedhia R.C. McVary K.T. Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. J. Urol. 2008 179 6 2119 2125 10.1016/j.juro.2008.01.094 18423748
    [Google Scholar]
  81. Allkanjari O. Vitalone A. What do we know about phytotherapy of benign prostatic hyperplasia? Life Sci. 2015 126 42 56 10.1016/j.lfs.2015.01.023 25703069
    [Google Scholar]
  82. Azimi H Khakshur A-A Aghdasi I Fallah-Tafti M Abdollahi M A review of animal and human studies for management of benign prostatic hyperplasia with natural products: Perspective of new pharmacological agents. Inflamm Allergy Drug Targets. 2012 11 3 207 221 10.2174/187152812800392715
    [Google Scholar]
  83. Hostanska K. Suter A. Melzer J. Saller R. Evaluation of cell death caused by an ethanolic extract of Serenoae repentis fructus (Prostasan) on human carcinoma cell lines. Anticancer Res. 2007 27 2 873 881 17465214
    [Google Scholar]
  84. Sun H. Li T.J. Sun L.N. Qiu Y. Huang B.B. Yi B. Chen W.S. Inhibitory effect of traditional Chinese medicine Zi-Shen Pill on benign prostatic hyperplasia in rats. J. Ethnopharmacol. 2008 115 2 203 208 10.1016/j.jep.2007.09.026 18024035
    [Google Scholar]
  85. Park H.S. Seo C.S. Wijerathne C.U.B. Jeong H.Y. Moon O.S. Seo Y.W. Won Y.S. Son H.Y. Lim J.H. Kwun H.J. Effect of Veratrum maackii on testosterone propionate-induced benign prostatic hyperplasia in rats. Biol. Pharm. Bull. 2019 42 1 1 9 10.1248/bpb.b18‑00313 30381617
    [Google Scholar]
  86. Rho J. Seo C.S. Park H.S. Wijerathne C.U.B. Jeong H.Y. Moon O.S. Seo Y.W. Son H.Y. Won Y.S. Kwun H.J. Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis. J. Ethnopharmacol. 2019 233 115 122 10.1016/j.jep.2018.11.042 30508623
    [Google Scholar]
  87. Tao R. Miao L. Yu X. Orgah J.O. Barnabas O. Chang Y. Liu E. Fan G. Gao X. Cynomorium songaricum Rupr demonstrates phytoestrogenic or phytoandrogenic like activities that attenuates benign prostatic hyperplasia via regulating steroid 5-α-reductase. J. Ethnopharmacol. 2019 235 65 74 10.1016/j.jep.2019.01.038 30708032
    [Google Scholar]
  88. Masrudin SS Athirah Razwan NI Mat Taib CN Mohd Nor NH Mohd Asri SF Alias Z Inhibitory effects of Pueraria mirifica Aqueous extracts on 5α-reductase and prostate histomorphometry in testosterone-induced benign prostatic hyperplasia sprague dawley rats. Malays J Med Health Sci. 2023 19 Supp 9 230 239 10.47836/mjmhs.19.s9.32
    [Google Scholar]
  89. Sarbishegi M. Khani M. Salimi S. Valizadeh M. Sargolzaei Aval F. Antiproliferative and antioxidant effects of withania coagulans extract on benign prostatic hyperplasia in rats. Nephrourol. Mon. 2016 8 1 e33180 10.5812/numonthly.33180 26981498
    [Google Scholar]
  90. Sasidharan S. Kp S. Bhaumik A. Kanti Das S. Nair J H. Administration of Caesalpinia bonduc seed extracts ameliorates testosterone-induced benign prostatic hyperplasia (BPH) in male wistar rats. Res. Rep. Urol. 2022 14 225 239 10.2147/RRU.S365598 35651598
    [Google Scholar]
  91. Mbaka GO Ogbonnia SO Olarewaju OT Duru FI The effects of ethanol seed extract of Raphia hookeri (Palmaceae) on exogenous testosterone and estradiol induced benign prostatic hyperplasia in adult male rats. J Morphol Sci. 2017 30 4 235 243
    [Google Scholar]
  92. Rajasree R.S. Ittiyavirah S.P. Poonkuzhi Naseef P. Saheer Kuruniyan M. Elayadeth-Meethal M. Sankar S. The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats. Saudi J. Biol. Sci. 2022 29 9 103396 10.1016/j.sjbs.2022.103396 35942162
    [Google Scholar]
  93. Usoh I.F. Akpan E.J. Etim E.O. Farombi E.O. Antioxidant actions of dried flower extracts of Hibiscus sabdariffa L. on sodium arsenite-induced oxidative stress in rats. Pak. J. Nutr. 2005 4 3 135 141 10.3923/pjn.2005.135.141
    [Google Scholar]
  94. Bm O-O. Fc A. Kr A. Em U. Ameliorating Potential of Annona muricata on Testosterone Propionate-Induced benign Prostatic Hyperplasia in Male Wistar Rats. Sch Int J Biochem 2022 5 2 28 36 10.36348/sijb.2022.v05i02.001
    [Google Scholar]
  95. Park J. Youn D.H. Um J.Y. Aconiti Lateralis radix Preparata, the dried root of Aconitum carmichaelii Debx., improves benign prostatic hyperplasia via suppressing 5‐alpha reductase and inducing prostate cell apoptosis. Evid. Based Complement. Alternat. Med. 2019 2019 1 1 10 10.1155/2019/6369132 31467577
    [Google Scholar]
  96. Blankstein U. Van Asseldonk B. Elterman D.S. BPH update: Medical versus interventional management. Can. J. Urol. 2016 23 Suppl. 1 10 15 26924590
    [Google Scholar]
  97. Pawlicki B Zieliński H Dabrowski M Role of apoptosis and chronic prostatitis in the pathogenesis of benign prostatic hyperplasia. Pol Merkur Lekarski 2004 17 100 307 310 26924590
    [Google Scholar]
  98. William F.P. Russa D.A. Prunus africanus herbal extracts reverse and ameliorate the histological and histomorphometric changes in testosterone-induced benign prostate hyperplasia rat models. Tanzan. J. Sci. 2021 47 3 1184 1194 10.4314/tjs.v47i3.27
    [Google Scholar]
  99. Dhanotia R. Chauhan N.S. Saraf D.K. Dixit V.K. Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Nat. Prod. Res. 2011 25 15 1432 1443 10.1080/14786410802632820 19764005
    [Google Scholar]
  100. Leibbrand M. Siefer S. Schön C. Perrinjaquet-Moccetti T. Kompek A. Csernich A. Bucar F. Kreuter M.H. Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: A pilot study in humans. J. Med. Food 2019 22 6 551 559 10.1089/jmf.2018.0106 31017505
    [Google Scholar]
  101. Andriole G. Bruchovsky N. Chung L.W.K. Matsumoto A.M. Rittmaster R. Roehrborn C. Russell D. Tindall D. Dihydrotestosterone and the prostate: The scientific rationale for 5α-reductase inhibitors in the treatment of benign prostatic hyperplasia. J. Urol. 2004 172 4 Pt 1 1399 1403 10.1097/01.ju.0000139539.94828.29 15371854
    [Google Scholar]
  102. Kang J.S. Zhao X.Y. Lee J.H. Lee J.S. Keum Y.S. Ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects. J. Cancer Prev. 2022 27 1 42 49 10.15430/JCP.2022.27.1.42 35419308
    [Google Scholar]
  103. Garcês H.M.P. Champagne C.E.M. Townsley B.T. Park S. Malhó R. Pedroso M.C. Harada J.J. Sinha N.R. Evolution of asexual reproduction in leaves of the genus Kalanchoë. Proc. Natl. Acad. Sci. USA 2007 104 39 15578 15583 10.1073/pnas.0704105104 17893341
    [Google Scholar]
  104. Palumbo A. Casanova L.M. Corrêa M.F.P. Da Costa N.M. Nasciutti L.E. Costa S.S. Potential therapeutic effects of underground parts of Kalanchoe gastonis-bonnieri on benign prostatic hyperplasia. Evid. Based Complement. Alternat. Med. 2019 2019 1 6340757 30719063
    [Google Scholar]
  105. Sim H.G. Cheng C.W.S. Changing demography of prostate cancer in Asia. Eur. J. Cancer 2005 41 6 834 845 10.1016/j.ejca.2004.12.033 15808953
    [Google Scholar]
  106. Summart R. Chewonarin T. Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial β-glucuronidase. Asian Pac. J. Cancer Prev. 2014 15 2 749 755 10.7314/APJCP.2014.15.2.749 24568490
    [Google Scholar]
  107. Kiriya C. Yeewa R. Khanaree C. Chewonarin T. Purple rice extract inhibits testosterone‐induced rat prostatic hyperplasia and growth of human prostate cancer cell line by reduction of androgen receptor activation. J. Food Biochem. 2019 43 9 e12987 10.1111/jfbc.12987 31489669
    [Google Scholar]
  108. Zhong W. Peng J. He H. Wu D. Han Z. Bi X. Dai Q. Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin. Invest. Med. 2008 31 1 8 10.25011/cim.v31i1.3136 18312749
    [Google Scholar]
  109. Strzalka W. Ziemienowicz A. Proliferating cell nuclear antigen (PCNA): A key factor in DNA replication and cell cycle regulation. Ann. Bot. 2011 107 7 1127 1140 10.1093/aob/mcq243 21169293
    [Google Scholar]
  110. Song K.H. Seo C.S. Yang W.K. Gu H.O. Kim K.J. Kim S.H. Extracts of Phyllostachys pubescens leaves represses human steroid 5-alpha reductase type 2 promoter activity in BHP-1 cells and ameliorates testosterone-induced benign prostatic hyperplasia in rat model. Nutrients 2021 13 3 884 10.3390/nu13030884 33803357
    [Google Scholar]
  111. Uroko R.I. Uche M.E. Nweje-Anyalowu P.C. Obiwuru I. Aguwamba C. Aaron C.F. Combined Anthocleista vogelii and Alstonia boonei Stem barks extract alleviates hyperlipidaemia and renal malfunctions in benign prostatic hyperplasia-induced rats. Biol. Med. Nat. Prod. Chem. 2023 12 1 69 78
    [Google Scholar]
  112. Uchenna E. Obinna A. e N.I. Effects of methanol extract of Allium sativa (MEAS) on hepatic and renal function biomarkers and Lipid profile of Testosterone propionate induced Benign Prostatic Hyperplasia male Rats. Saudi J. Med. Pharm. Sci. 2023 9 5 287 296 10.36348/sjmps.2023.v09i05.003
    [Google Scholar]
  113. Ekeyi Y. Uchendu N.O. Anaduaka E.G. Ezeanyika L.U.S. Ethanol extract of Cassia sieberiana leaves ameliorates deviances associated with benign prostatic hyperplasia in rats. All Life 2021 14 1 473 483 10.1080/26895293.2021.1927857
    [Google Scholar]
  114. Palomino-De-La-Gala R. Justil-Guerrero H. Arroyo-Acevedo J. Rojas-Armas J. Aguilar-Carranza C. Martínez-Heredia J. Cieza-Macedo E. Garcia-Bustamante C. Herrera-Calderon O. Enciso-Roca E. Chavez-Asmat R. Dominguez-Huarcaya L. Protective effect of the ethanolic extracts of leaves of Chuquiraga spinosa Less and Baccharis genistelloides on benign prostatic hyperplasia in rats. Pharmacogn. J. 2019 11 5 858 865 10.5530/pj.2019.11.138
    [Google Scholar]
  115. John JI Uchendu NO Chukwuma IF Obinna M Chemotherapeutic evaluation of ethanol extract of chromolaena odorata on biochemical aberrations associated with experimentally-induced benign prostatic hyperplasia in male rats. Biointerface Res Appl Chem. 2022 12 6 8426 8440 10.33263/briac126.84268440
    [Google Scholar]
  116. Oberai P. Roja V. Ramesh D. Arya D. Reddy G. Sharma S. Nayak C. Singh V. Singh H. Homoeopathic medicines in the management of benign prostatic hyperplasia: A multicentric prospective observational study. Indian J. Res. Homoeopathy 2012 6 3 16 25 10.53945/2320‑7094.1694
    [Google Scholar]
  117. Nayak C. Hati A.K. Dash S.K. Paital B. Benign prostatic hyperplasia and homoeopathic treatment: Case study of a 64 years old patient. Indo Am. J. Pharm. Sci. 2017 4 12 4695
    [Google Scholar]
  118. Gupta G. Kumar A. Sexena R. Nayak C. Homoeopathic treatment of benign prostatic hyperplasia: A case series. Homoeopath. Links 2018 31 3 209 219 10.1055/s‑0038‑1673648
    [Google Scholar]
  119. Mehra P. Roja V. Sharma B. Oberai P. Reddy G.R.C. Arya D.D. Raja Kumar B.S.J. Mohanan P.G. Prusty A.K. Padmanabhan M. Manchanda R.K. Homoeopathic treatment for lower urinary tract symptoms in men with benign prostatic hyperplasia: An open label randomised multicentric placebo-controlled clinical trial. Indian J. Res. Homoeopathy 2018 12 3 113 124 10.4103/ijrh.ijrh_36_18
    [Google Scholar]
  120. Ezz El Din K. Koch W.F.R.M. de Wildt M.J.A.M. Kiemeney L.A.L.M. Debruyne F.M.J. de la Rosette J.J.M.C.H. Reliability of the international prostate symptom score in the assessment of patients with lower urinary tract symptoms and/or benign prostatic hyperplasia. J. Urol. 1996 155 6 1959 1964 10.1016/S0022‑5347(01)66061‑0 8618297
    [Google Scholar]
  121. Biswas B Mandal S Abbas J Benign prostatic hyperplasia treated with individualised homoeopathic medicines: An evidence-based case series. J Integr Stand Homoeopathy 2022 5 4 100
    [Google Scholar]
  122. Lokeshwar S.D. Harper B.T. Webb E. Jordan A. Dykes T.A. Neal D.E. Jr Terris M.K. Klaassen Z. Epidemiology and treatment modalities for the management of benign prostatic hyperplasia. Transl. Androl. Urol. 2019 8 5 529 539 10.21037/tau.2019.10.01 31807429
    [Google Scholar]
  123. Yadav AK Yadav R Das AK Saini D Mishra M Individualized homoeopathic treatment for benign prostatic hyperplasia: A holistic approach to prostate health: A case report. Int J Homoeopath Sci 2024 8 2 341 345 10.33545/26164485.2024.v8.i2e.1156
    [Google Scholar]
  124. Patel G. Shah P. Individualized homeopathy as an adjunct in the treatment of benign hypertrophy of prostate (BHP): A randomized controlled trial. Natl. J. Integr. Res. Med. 2018 9 6
    [Google Scholar]
  125. Macoska J.A. The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia. Am. J. Clin. Exp. Urol. 2023 11 6 467 480 38148931
    [Google Scholar]
  126. Choi Y.J. Fan M. Wedamulla N.E. Tang Y. Bae S.M. Hwang J.Y. Kim E.K. Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways. Food Funct. 2022 13 19 10235 10247 10.1039/D2FO00841F 36124918
    [Google Scholar]
  127. Wang S. He W. Li W. Zhou J.R. Du Z. Combination of lycopene and curcumin synergistically alleviates testosterone-propionate-induced benign prostatic hyperplasia in sprague dawley rats via modulating inflammation and proliferation. Molecules 2023 28 13 4900 10.3390/molecules28134900 37446563
    [Google Scholar]
  128. Wang Y.Y. Zhu G.Q. Xia K. Zeng H.B. He Y.H. Xie H. Wang Z.X. Xu R. Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation. Mol. Med. 2024 30 1 41 10.1186/s10020‑024‑00805‑y 38519941
    [Google Scholar]
  129. Jeon E. Chung K.S. An H.J. Anti-proliferation effects of Cistanches salsa on the progression of benign prostatic hyperplasia. Can. J. Physiol. Pharmacol. 2016 94 1 104 111 10.1139/cjpp‑2015‑0112 27123496
    [Google Scholar]
  130. Rehman T. Ahmad S. Abbasi W. Homoeopathic approach for the treatment of cancer. Indian J. Res. Homoeopathy 2018 12 3 157 163 10.4103/ijrh.ijrh_61_17
    [Google Scholar]
  131. Karso L. A multidisciplinary management framework for the treatment of benign prostatic hyperplasia with focus on homoeopathy: A review. Homoeopath. Links 2020 10.1055/s‑0040‑1715106
    [Google Scholar]
  132. Sharma AK Mandal B Madan S Rajput SK Challenges and opportunities in standardization of homeopathic drugs and dilutions. Herbal Medicine in India: Indigenous Knowledge, Practice, Innovation and its Value. Springer Singapore 2020 591 598 10.1007/978‑981‑13‑7248‑3_36
    [Google Scholar]
  133. Satti J. Homeopathic drug standardization. Semin. Integr. Med. 2005 3 4 113 122
    [Google Scholar]
  134. Stub T. Musial F. Kristoffersen A.A. Alræk T. Liu J. Adverse effects of homeopathy, what do we know? A systematic review and meta-analysis of randomized controlled trials. Complement. Ther. Med. 2016 26 146 163 10.1016/j.ctim.2016.03.013 27261996
    [Google Scholar]
  135. Wagenknecht A. Dörfler J. Freuding M. Josfeld L. Huebner J. Homeopathy effects in patients during oncological treatment: A systematic review. J. Cancer Res. Clin. Oncol. 2023 149 5 1785 1810 10.1007/s00432‑022‑04054‑6 35731274
    [Google Scholar]
  136. Sudeep H.V. Thomas J.V. Shyamprasad K. A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency. BMC Urol. 2020 20 1 86 10.1186/s12894‑020‑00648‑9 32620155
    [Google Scholar]
  137. Tran D.N.H. Yeh H.F. Huang W.J. Wu P.W. Liao Y.J. Hwang S.J. Kung Y.Y. Yang J.L. Wu T.P. Hsu C.H. Chen F.P. Efficacy evaluation of Chinese herbal medicine, VGH-BPH1, for patients with benign prostatic hyperplasia: A randomized, double-blind, placebo-controlled, and crossover study. J. Chin. Med. Assoc. 2022 85 5 639 646 10.1097/JCMA.0000000000000717 35385425
    [Google Scholar]
  138. Ma C.H. Lin W.L. Lui S.L. Cai X.Y. Wong V.T. Ziea E. Zhang Z.J. Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: Systematic review of randomized controlled trials. Asian J. Androl. 2013 15 4 471 482 10.1038/aja.2012.173 23728585
    [Google Scholar]
  139. Vela-Navarrete R. Alcaraz A. Rodríguez-Antolín A. Miñana López B. Fernández-Gómez J.M. Angulo J.C. Castro Díaz D. Romero-Otero J. Brenes F.J. Carballido J. Molero García J.M. Fernández-Pro Ledesma A. Cózar Olmos J.M. Manasanch Dalmau J. Subirana Cachinero I. Herdman M. Ficarra V. Efficacy and safety of a hexanic extract of Serenoa repens (Permixon ® ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia ( LUTS / BPH ): Systematic review and meta‐analysis of randomised controlled trials and observational studies. BJU Int. 2018 122 6 1049 1065 10.1111/bju.14362 29694707
    [Google Scholar]
  140. Russo A. Capogrosso P. La Croce G. Ventimiglia E. Boeri L. Briganti A. Damiano R. Montorsi F. Salonia A. Serenoa repens, selenium and lycopene to manage lower urinary tract symptoms suggestive for benign prostatic hyperplasia. Expert Opin. Drug Saf. 2016 15 12 1661 1670 10.1080/14740338.2016.1190830 27232207
    [Google Scholar]
/content/journals/cctr/10.2174/0115733947375503250326074355
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A Mini Overview of Recent Herbal Medicines Innovations Progress against Benign Prostate Hyperplasia
Bentham Science Publishers ; https://doi.org/10.2174/0115733947375503250326074355
/content/journals/cctr/10.2174/0115733947375503250326074355
/content/journals/cctr/10.2174/0115733947375503250326074355
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  • Article Type:     Review Article
Keywords: phytotherapy ; medicinal plants ; folk medicine ; Benign prostatic hyperplasia ; clinical data ; etiology

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