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2000
Volume 22, Issue 2
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Introduction

Lung cancer (LC) is considered the leading type of cancer in the world. Similar to other countries, smoking is known as the main reason for this disease. The present study aims to assess the critical factors and risk assessment of LC in Iran.

Materials and Methods

Eligible studies were identified in Web of Science, Google Scholar, GLOBOCAN data base, PubMed, Science Direct, Scopus, ScieLo, and HAL to find the relevant ones published up to September 2024. Then, the relevant studies were analyzed using the keywords such as “risk factor or lung cancer” and “lung cancers or lung tumor”. Finally, the supplementary studies were addressed by the data provided by the Health Department at the Ministry of Health and Medical Education of the Islamic Republic of Iran.

Results

Smoking cigarette increases the cases which are at risk as secondhand smokers. The pattern of smoking in Iran is increasing, especially among women at young ages. There is scattered and vague information about gas, air pollution, nutrition and obesity, genetics, occupational exposure, and lifestyle in LC.

Discussion

Based on peer-reviewed published articles and reports from around the world, including a recent investigation into critical factors and risk assessment of lung cancer, we discuss this issue in more detail in the current manuscript discussion section.

Conclusion

Smoking is regarded as the most vital risk factor for LC. However, other risk factors exist, which should be considered in this disease. This study seeks to present the promise of prevention, as well as providing suggestions to healthcare workers.

© 2026 Bentham Science Publishers
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References

  1. HenryM.M. KwunM.F. Lung cancer screening - Time for an update?Ann. Oncol.200920556563
     [Google Scholar]
  2. LoPiccoloJ. GusevA. ChristianiD.C. JänneP.A. Lung cancer in patients who have never smoked - An emerging disease.Nat. Rev. Clin. Oncol.202421212114610.1038/s41571‑023‑00844‑0 38195910
     [Google Scholar]
  3. GhasemiS. MahakiB. DreassiE. AghamohammadiS. Spatial variation in lung cancer mortality and related men–women disparities in iran from 2011 to 2014.Cancer Manag. Res.2020124615462410.2147/CMAR.S247178 32606954
     [Google Scholar]
  4. CuenotL Valnet-RabierMB BendjamaA AubinF FischerS ViotJ Serious adverse effects with immunotherapies for the treatment of melanoma, non-small cell lung cancer, and renal cell carcinoma: Real-world evidence study. Bull Cancer20249S00074551(24)00332-1
     [Google Scholar]
  5. JiangW WangY ZouJ LiL XuC. UBE2Q1 as a novel cancer biomarker for lung adenocarcinoma.Am J Med Sci20248S0002-9629(24)01481-210.1016/j.amjms.2024.10.002
     [Google Scholar]
  6. TenekeciA.K. UnalA.A. CeylanF. Nahit SendurM.A. An updated overview of K-RAS G12C inhibitors in advanced stage non-small cell lung cancer.Future Oncol.202420373019303810.1080/14796694.2024.2407280 39360933
     [Google Scholar]
  7. De KoningH. Van Der AalstC. ten HaafK. OudkerkM. Effects of volume CT lung cancer screening.19th World Conference on Lung CancerToronto, CanadaSeptember 23–26, 2018
     [Google Scholar]
  8. LagunaJ.C. García-PardoM. AlessiJ. Geographic differences in lung cancer: Focus on carcinogens, genetic predisposition, and molecular epidemiology.Ther. Adv. Med. Oncol.2024161758835924123126010.1177/17588359241231260 38455708
     [Google Scholar]
  9. PelosofL. AhnC. GaoA. Proportion of never-smoker non-small cell lung cancer patients at three diverse institutions.J. Natl. Cancer Inst.20171097djw29510.1093/jnci/djw295
     [Google Scholar]
  10. ThunM.J. HannanL.M. Adams-CampbellL.L. Lung cancer occurrence in never-smokers: An analysis of 13 cohorts and 22 cancer registry studies.PLoS Med.200859e18510.1371/journal.pmed.0050185 18788891
     [Google Scholar]
  11. IslamiF. StoklosaM. DropeJ. JemalA. Global and regional patterns of tobacco smoking and tobacco control policies.Eur. Urol. Focus20151131610.1016/j.euf.2014.10.001 28723352
     [Google Scholar]
  12. HamzehB. FarniaV. MoradinazarM. Pattern of cigarette smoking: Intensity, cessation, and age of beginning: Evidence from a cohort study in West of Iran.Subst. Abuse Treat. Prev. Policy20201518310.1186/s13011‑020‑00324‑z 33109215
     [Google Scholar]
  13. KhodadostM. MaajaniK. NorooziA. Prevalence of cigarette smoking among college students in Iran: An updated systematic review and meta-analysis of observational studies.Med. J. Islam. Repub. Iran20203416510.47176/mjiri.34.165 33816364
     [Google Scholar]
  14. ChaayaM. Mehio-SibaiA. El-ChemalyS. Smoking patterns and predictors of smoking cessation in elderly populations in Lebanon.Int. J. Tuberc. Lung Dis.2006108917923 16898378
     [Google Scholar]
  15. KhuderS.A. Effect of cigarette smoking on major histological types of lung cancer: A meta-analysis.Lung Cancer2001312-313914810.1016/S0169‑5002(00)00181‑1 11165392
     [Google Scholar]
  16. CarterB.D. AbnetC.C. FeskanichD. Smoking and mortality--beyond established causes.N. Engl. J. Med.2015372763164010.1056/NEJMsa1407211 25671255
     [Google Scholar]
  17. LubinJ.H. CaporasoN.E. Cigarette smoking and lung cancer: Modeling total exposure and intensity.Cancer Epidemiol. Biomarkers Prev.200615351752310.1158/1055‑9965.EPI‑05‑0863 16537710
     [Google Scholar]
  18. HammondD. FongG.T. CummingsK.M. HylandA. Smoking topography, brand switching, and nicotine delivery: Results from an in vivo study.Cancer Epidemiol. Biomarkers Prev.20051461370137510.1158/1055‑9965.EPI‑04‑0498 15941943
     [Google Scholar]
  19. CarmellaS.G. ChenM. HanS. Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers.Chem. Res. Toxicol.200922473474110.1021/tx800479s 19317515
     [Google Scholar]
  20. De VitaM.J. MaistoS.A. AnsellE.B. ZaleE.L. Pack-years of tobacco cigarette smoking as a predictor of spontaneous pain reporting and experimental pain reactivity.Exp. Clin. Psychopharmacol.2019276552
     [Google Scholar]
  21. MacRostyC.R. RiveraM.P. Lung cancer in women: A modern epidemic.Clin. Chest Med.2020411536510.1016/j.ccm.2019.10.005 32008629
     [Google Scholar]
  22. CarrerasG. LugoA. GallusS. Burden of disease attributable to second-hand smoke exposure: A systematic review.Prev. Med.201912910583310.1016/j.ypmed.2019.105833 31505203
     [Google Scholar]
  23. HirayamaT. Non-smoking wives of heavy smokers have a higher risk of lung cancer: A study from Japan.BMJ1981282625918318510.1136/bmj.282.6259.183 6779940
     [Google Scholar]
  24. XuZ.Y. BlotW.J. XiaoH.P. Smoking, air pollution, and the high rates of lung cancer in Shenyang, China.J. Natl. Cancer Inst.198981231800180610.1093/jnci/81.23.1800 2555531
     [Google Scholar]
  25. Hashemi-AghdamM.R. ShafieeG. EbrahimiM. Trend of passive smoking and associated factors in Iranian children and adolescents: The CASPIAN studies.BMC Public Health202222160310.1186/s12889‑022‑13045‑8 35351076
     [Google Scholar]
  26. KashaniH. NakhjirganP. HassanvandM.S. Subnational exposure to secondhand smoke in Iran from 1990 to 2013: A systematic review.Environ. Sci. Pollut. Res. Int.20212832608262510.1007/s11356‑020‑11199‑9 33140301
     [Google Scholar]
  27. Abbasi-KangevariM. MasinaeiM. FattahiN. Current inequities in smoking prevalence on district level in Iran: A systematic analysis on the STEPS survey.J. Res. Health Sci.2021221e0054010.34172/jrhs.2022.75 36511256
     [Google Scholar]
  28. LiuY. XuY. XuW. HeZ. FuC. DuF. Radon and lung cancer: Current status and future prospects.Crit. Rev. Oncol. Hematol.202419810436310.1016/j.critrevonc.2024.104363 38657702
     [Google Scholar]
  29. Shahbazi-GahroueiD. GholamiM. SetayandehS. A review on natural background radiation.Adv. Biomed. Res.2013216510.4103/2277‑9175.115821 24223380
     [Google Scholar]
  30. ChengE.S. EggerS. HughesS. Systematic review and meta-analysis of residential radon and lung cancer in never-smokers.Eur. Respir. Rev.20213015920023010.1183/16000617.0230‑2020 33536262
     [Google Scholar]
  31. AppletonJ.D. JonesD.G. MilesJ.C. ScivyerC. Radon gas hazard.Geol Soc London Eng Geol Spec Publ2020291433456
     [Google Scholar]
  32. Shahbazi SehraniM. BoudaqpoorS. MirmohammadiM. Measurement of indoor radon gas concentration and assessment of health risk in Tehran, Iran.Int. J. Environ. Sci. Technol.20191662619262610.1007/s13762‑018‑1715‑x
     [Google Scholar]
  33. SherafatS. Nemati MansourS. MosaferiM. AminisaniN. YousefiZ. MalekiS. First indoor radon mapping and assessment excess lifetime cancer risk in Iran.MethodsX201962205221610.1016/j.mex.2019.09.028 31667121
     [Google Scholar]
  34. SongY. WangR. WangJ. TanX. MaJ. Global burden of lung cancer in women of childbearing age attributable to ambient particulate matter pollution: 1990–2021.Cancer Med.20241318e7024110.1002/cam4.70241 39315583
     [Google Scholar]
  35. MøllerP. JacobsenN.R. FolkmannJ.K. Role of oxidative damage in toxicity of particulates.Free Radic. Res.201044114610.3109/10715760903300691 19886744
     [Google Scholar]
  36. PershagenG. Air pollution and cancer.IARC Sci Publ19901104240251 2228122
     [Google Scholar]
  37. ShariepourZ. Aliakbari BidokhtiA. An Investigation on the status of troposphere NO2 over Iran during 2004 to 2012.J. Environ. Stud.20144016578
     [Google Scholar]
  38. RaispourK. Sulfur dioxide (SO2) monitoring based on metop-a/gome-2 sensor observations in the troposphere of Iran.J. Environ. Stud.2021472103120
     [Google Scholar]
  39. TaghvaeeS. SowlatM.H. HassanvandM.S. YunesianM. NaddafiK. SioutasC. Source-specific lung cancer risk assessment of ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in central Tehran.Environ. Int.201812032133210.1016/j.envint.2018.08.003 30107293
     [Google Scholar]
  40. KhorramiZ. PourkhosravaniM. RezapourM. Multiple air pollutant exposure and lung cancer in Tehran, Iran.Sci. Rep.2021111923910.1038/s41598‑021‑88643‑4 33927268
     [Google Scholar]
  41. BrownT. DarntonA. FortunatoL. RushtonL. Occupational cancer in Britain.Br. J. Cancer2012107S1Suppl. 1S56S7010.1038/bjc.2012.119 22710680
     [Google Scholar]
  42. HodgsonJ. DarntonA. The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure.Ann. Occup. Hyg.200044856560110.1016/S0003‑4878(00)00045‑4 11108782
     [Google Scholar]
  43. LubinJ.H. MooreL.E. FraumeniJ.F.Jr CantorK.P. Respiratory cancer and inhaled inorganic arsenic in copper smelters workers: A linear relationship with cumulative exposure that increases with concentration.Environ. Health Perspect.2008116121661166510.1289/ehp.11515 19079717
     [Google Scholar]
  44. DehghaniZ. RanjbarS. ShahabinezhadF. SabouriP. MohammadiA. A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human.Toxicol. Res.2024245tfae151
     [Google Scholar]
  45. ShankarA. DubeyA. SainiD. Environmental and occupational determinants of lung cancer.Transl. Lung Cancer Res.20198S1Suppl. 1S31S4910.21037/tlcr.2019.03.05 31211104
     [Google Scholar]
  46. SivulkaD.J. SeilkopS.K. Reconstruction of historical exposures in the US nickel alloy industry and the implications for carcinogenic hazard and risk assessments.Regul. Toxicol. Pharmacol.200953317418510.1016/j.yrtph.2009.01.006 19545511
     [Google Scholar]
  47. ColeP. RoduB. Epidemiologic studies of chrome and cancer mortality: A series of meta-analyses.Regul. Toxicol. Pharmacol.200543322523110.1016/j.yrtph.2005.06.009 16099572
     [Google Scholar]
  48. RahmanN.A.A.A. Ma’Radzi AH, Zakaria A. Fabrication of quartz crystal microbalance with pegylated lipopolymer for detection of non-invasive lung cancer biomarker.Mater. Today Proc.2019763263710.1016/j.matpr.2018.12.054
     [Google Scholar]
  49. LacasseY. MartinS. GagnéD. LakhalL. Dose–response meta-analysis of silica and lung cancer.Cancer Causes Control200920692593310.1007/s10552‑009‑9296‑0 19184475
     [Google Scholar]
  50. SpyratosD ZarogoulidisP PorpodisK Occupational exposure and lung cancer. J Thorac Dis20135(Suppl 4)(Suppl. 4):S440-524102018
     [Google Scholar]
  51. HosseiniB. HallA.L. ZendehdelK. Occupational exposure to carcinogens and occupational epidemiological cancer studies in Iran: A review.Cancers20211314358110.3390/cancers13143581 34298794
     [Google Scholar]
  52. Mosavi-JarrahiA. MohagheghiM. KalaghchiB. Mousavi-JarrahiY. NooriM.K. Estimating the incidence of lung cancer attributable to occupational exposure in Iran.Popul. Health Metr.200971710.1186/1478‑7954‑7‑7 19435522
     [Google Scholar]
  53. BenetouV. OrfanosP. LagiouP. TrichopoulosD. BoffettaP. TrichopoulouA. Vegetables and fruits in relation to cancer risk: Evidence from the Greek EPIC cohort study.Cancer Epidemiol. Biomarkers Prev.200817238739210.1158/1055‑9965.EPI‑07‑2665 18268122
     [Google Scholar]
  54. WangJ. GaoJ. XuH. Citrus fruit intake and lung cancer risk: A meta-analysis of observational studies.Pharmacol. Res.202116610543010.1016/j.phrs.2021.105430 33529754
     [Google Scholar]
  55. ChristensenK.Y. NaiduA. ParentM.É. The risk of lung cancer related to dietary intake of flavonoids.Nutr. Cancer201264796497410.1080/01635581.2012.717677 23061904
     [Google Scholar]
  56. AdeyeyeS.A.O. AshaoluT.J. Heterocyclic amine formation and mitigation in processed meat and meat products: A mini-review.J. Food Prot.202184111868187710.4315/JFP‑20‑471 33956955
     [Google Scholar]
  57. YangW.S. VaP. WongM.Y. ZhangH.L. XiangY.B. Soy intake is associated with lower lung cancer risk: Results from a meta-analysis of epidemiologic studies.Am. J. Clin. Nutr.20119461575158310.3945/ajcn.111.020966 22071712
     [Google Scholar]
  58. Smith-WarnerS.A. RitzJ. HunterD.J. Dietary fat and risk of lung cancer in a pooled analysis of prospective studies.Cancer Epidemiol. Biomarkers Prev.20021110 Pt 1987992 12376497
     [Google Scholar]
  59. SatiaJ.A. LittmanA. SlatoreC.G. GalankoJ.A. WhiteE. Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: Results from the VITamins And Lifestyle (VITAL) study.Am. J. Epidemiol.2009169781582810.1093/aje/kwn409 19208726
     [Google Scholar]
  60. AlsharairiN.A. The effects of dietary supplements on asthma and lung cancer risk in smokers and non-smokers: A review of the literature.Nutrients201911472510.3390/nu11040725 30925812
     [Google Scholar]
  61. AzadnajafabadS. MohammadiE. AminorroayaA. Non-communicable diseases’ risk factors in Iran; A review of the present status and action plans.J. Diabetes Metab. Disord.2021221910.1007/s40200‑020‑00709‑8 33500879
     [Google Scholar]
  62. HosseiniM. NaghanP.A. JafariA.M. Nutrition and lung cancer: A case control study in Iran.BMC Cancer201414186010.1186/1471‑2407‑14‑860 25416035
     [Google Scholar]
  63. SadeghiA. ParastoueiK. SeifiS. Inflammatory potential of diet and odds of lung cancer: A case-control study.Nutr. Cancer20227482859286710.1080/01635581.2022.2036770 35132900
     [Google Scholar]
  64. WangP. SunS. LamS. LockwoodW.W. New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment.J. Transl. Med.202321158510.1186/s12967‑023‑04430‑x 37653450
     [Google Scholar]
  65. TianX. LiuZ. Single nucleotide variants in lung cancer.Chin Med J Pulm Crit Care Med202422889410.1016/j.pccm.2024.04.004 39169933
     [Google Scholar]
  66. FongK.M. SekidoY. MinnaJ.D. The molecular basis of lung carcinogenesis.The molecular basis of human cancer.Totowa, NJHumana Press200237940510.1007/978‑1‑59259‑125‑1_17
     [Google Scholar]
  67. NadjiS.A. MahmoodiM. ZiaeeA.A. An increased lung cancer risk associated with codon 72 polymorphism in the TP53 gene and human papillomavirus infection in Mazandaran province, Iran.Lung Cancer200756214515110.1016/j.lungcan.2006.12.006 17208332
     [Google Scholar]
  68. JafariH. Genotyping of human papillomavirus and TP53 mutations at exons 5 to 7 in lung cancer patients from Iran. BI201333135
     [Google Scholar]
  69. PotterJ.D. McMichaelA.J. Alcohol, beer and lung cancer--a meaningful relationship?Int. J. Epidemiol.198413224024210.1093/ije/13.2.240 6376387
     [Google Scholar]
  70. FreudenheimJ.L. RitzJ. Smith-WarnerS.A. Alcohol consumption and risk of lung cancer: A pooled analysis of cohort studies.Am. J. Clin. Nutr.200582365766710.1093/ajcn/82.3.657 16155281
     [Google Scholar]
  71. KaurG. KumarB.V.S. SinghB. SethiR.S. Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway.J. Occup. Med. Toxicol.2021161142710.1186/s12995‑021‑00304‑4
     [Google Scholar]
  72. BanderaE.V. FreudenheimJ.L. VenaJ.E. Alcohol consumption and lung cancer: A review of the epidemiologic evidence.Cancer Epidemiol. Biomarkers Prev.2001108813821 11489747
     [Google Scholar]
  73. SaracciR. The interactions of tobacco smoking and other agents in cancer etiology.Epidemiol. Rev.19879117519310.1093/oxfordjournals.epirev.a036301 3315716
     [Google Scholar]
  74. ChegeniM. KhodabandehA.K. KaramouzianM. Alcohol consumption in Iran: A systematic review and meta‐analysis of the literature.Drug Alcohol Rev.202039552553810.1111/dar.13093 32441436
     [Google Scholar]
  75. SamadiS. BaneshiM.R. HaghdoostA.A. Pattern of alcohol consumption among men consumers in Kerman, Iran.Addict. Health201793139145 29657694
     [Google Scholar]
  76. SchwartzA.G. RuckdeschelJ.C. Familial lung cancer: Genetic susceptibility and relationship to chronic obstructive pulmonary disease.Am. J. Respir. Crit. Care Med.20061731162210.1164/rccm.200502‑235PP 16141445
     [Google Scholar]
  77. BrownS.A.W. PadillaM. MhangoG. Interstitial lung abnormalities and lung cancer risk in the national lung screening trial.Chest201915661195120310.1016/j.chest.2019.06.041 31404527
     [Google Scholar]
  78. ArtinianV. KvaleP.A. Cancer and interstitial lung disease.Curr. Opin. Pulm. Med.200410542543410.1097/00063198‑200409000‑00017 15316443
     [Google Scholar]
  79. Le JeuneI. GribbinJ. WestJ. SmithC. CullinanP. HubbardR. The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK.Respir. Med.2007101122534254010.1016/j.rmed.2007.07.012 17870458
     [Google Scholar]
  80. NishinoM. CardarellaS. DahlbergS.E. Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival.Eur. J. Radiol.2015845998100410.1016/j.ejrad.2015.01.021 25726730
     [Google Scholar]
  81. RenehanAG TysonM EggerM HellerRF ZwahlenM Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies.Lancet200837196125697810.1016/S0140‑6736(08)60269‑X 18280327
     [Google Scholar]
  82. ShepshelovichD. XuW. LuL. Body mass index (BMI), BMI change, and overall survival in patients with SCLC and NSCLC: A pooled analysis of the international lung cancer consortium.J. Thorac. Oncol.20191491594160710.1016/j.jtho.2019.05.031 31163278
     [Google Scholar]
  83. GallagherE.J. LeRoithD. Hyperinsulinaemia in cancer.Nat. Rev. Cancer2020201162964410.1038/s41568‑020‑0295‑5 32908223
     [Google Scholar]
  84. ChanY.X. AlfonsoH. ChubbS.A.P. Higher dihydrotestosterone is associated with the incidence of lung cancer in older men.Horm. Cancer20178211912610.1007/s12672‑017‑0287‑4 28233278
     [Google Scholar]
  85. VelchetiV. GovindanR. Insulin-like growth factor and lung cancer.J. Thorac. Oncol.200617607610 17409926
     [Google Scholar]
  86. FergusonR.D. GallagherE.J. CohenD. Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer.Endocr. Relat. Cancer201320339140110.1530/ERC‑12‑0333 23572162
     [Google Scholar]
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Monitoring based on Risk Assessment Effects on Lung Cancer in Iran
Curr Cancer Ther Rev 22, 200 (2026); https://doi.org/10.2174/0115733947343796250109051943
/content/journals/cctr/10.2174/0115733947343796250109051943
/content/journals/cctr/10.2174/0115733947343796250109051943
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  • Article Type:     Research Article
Keyword(s): assessment; health changes; incidence; lifetime; Lung cancer; risk factors

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