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2000
Volume 21, Issue 7
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Cancer is a life-threatening disease, and there are very few options to treat it almost completely, with a high percentage of success rates. Proton therapy is a very unique and one of the latest techniques to treat cancer with a very promising percentage of success rate. In this therapy, a proton particle with high velocity is used, and it is superior to conventional photon or radiotherapy. In this review, we have discussed the theoretical aspects of this technique and the latest variant of this therapy called pencil beam proton therapy, which is a cutting-edge technique to treat cancer. We have also tried to discuss the applications of proton therapy for different types of cancers.

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2024-05-27
2025-12-05

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References

  1. MukherjeeS. GiriS. MaityS. GhoshB. A brief review on therapeutic potential of nanocarrier systems against breast cancer.J. Biomol. Res. Ther.20198174
     [Google Scholar]
  2. KaratiD. MukherjeeS. RoyS. An explicative review on the current advancement in schiff base-metal complexes as anticancer agents evolved in the past decade: Medicinal chemistry aspects.Med. Chem.2023191096098510.2174/1573406419666230707105221 37424341
     [Google Scholar]
  3. KaratiD. MukherjeeS. RoyS. Deciphering the molecular mechanistic paths describing the chemotherapeutic potential and epigenetic regulation of curcumin in lung cancer: A mini review.Naunyn Schmiedebergs Arch. Pharmacol.20231110.1007/s00210‑023‑02838‑2 37982888
     [Google Scholar]
  4. TianX. LiuK. HouY. ChengJ. ZhangJ. The evolution of proton beam therapy: Current and future status.Mol. Clin. Oncol.2018811521 29399346
     [Google Scholar]
  5. WilsonR.R. Radiological use of fast protons.Radiology194647548749110.1148/47.5.487 20274616
     [Google Scholar]
  6. HuM. JiangL. CuiX. ZhangJ. YuJ. Proton beam therapy for cancer in the era of precision medicine.J. Hematol. Oncol.201811113610.1186/s13045‑018‑0683‑4 30541578
     [Google Scholar]
  7. MohanR. GrosshansD. Proton therapy – Present and future.Adv. Drug Deliv. Rev.2017109264410.1016/j.addr.2016.11.006 27919760
     [Google Scholar]
  8. DeLaneyT.F. Proton therapy in the clinic.Front. Radiat. Ther. Oncol.20114346548510.1159/000322511 21625169
     [Google Scholar]
  9. PaganettiH. NiemierkoA. AncukiewiczM. Relative biological effectiveness (RBE) values for proton beam therapy.Int. J. Radiat. Oncol. Biol. Phys.200253240742110.1016/S0360‑3016(02)02754‑2 12023146
     [Google Scholar]
  10. BraggW.H. KleemanR. XXXIX. On the α particles of radium, and their loss of range in passing through various atoms and molecules.Lond. Edinb. Dublin Philos. Mag. J. Sci.1905105731834010.1080/14786440509463378
     [Google Scholar]
  11. KjellbergR.N. KoehlerA.M. PrestonW.M. SweetW.H. Stereotaxic instrument for use with the Bragg peak of a proton beam.Stereotact. Funct. Neurosurg.1962223-518318910.1159/000104360 14033248
     [Google Scholar]
  12. PhanJ. SioT.T. NguyenT.P. Reirradiation of head and neck cancers with proton therapy: Outcomes and analyses.Int. J. Radiat. Oncol. Biol. Phys.2016961304110.1016/j.ijrobp.2016.03.053 27325480
     [Google Scholar]
  13. HoJ.C. NguyenQ.N. LiH. Reirradiation of thoracic cancers with intensity modulated proton therapy.Pract. Radiat. Oncol.201881586510.1016/j.prro.2017.07.002 28867546
     [Google Scholar]
  14. SlaterJ.M. SchwartzM.S. ThorntonA. Proton therapy: Expanding the role in cancer treatment.Cancer J Clin Publication1995455365383
     [Google Scholar]
  15. WeberD.C. SchaffnerB. BöhlenT. EpelbaumA.P.M. Development of particle therapy at the paul scherrer institute: A historic overview.Strahlentherapie und Onkologie Publication20191959771778
     [Google Scholar]
  16. ClementM. Particle therapy for cancer: Briefing material for the standing committee on health.In: Canadian Association of Provincial Cancer Agencies.CAPCA2006
     [Google Scholar]
  17. RichterS. First Helmholtz proton therapy center opens in Heidelberg.Phys. J.2009847
     [Google Scholar]
  18. DebusJ. BüchlerM.W. ParodiK. The new heidelberg ion-beam therapy center (HIT): Status and perspectives.Int. J. Radiat. Oncol. Biol. Phys.2004582616621
     [Google Scholar]
  19. SubramanianS. Proton therapy: The Indian scenario.Indian J. Cancer2017542321322
     [Google Scholar]
  20. GordonK. GulidovI. SemenovA. Proton re-irradiation of unresectable recurrent head and neck cancers.Rep. Pract. Oncol. Radiother.202126220321010.5603/RPOR.a2021.0029 34211770
     [Google Scholar]
  21. First patients treated in dimitrovgrad proton therapy center, Russia.Available from: https://www.iba-worldwide.com/first-patients-treated-dimitrovgrad-proton-therapy-center-russia
  22. What is proton therapy?Available from: https://protherapy.ru/en/what-is-proton-therapy
  23. XuN. HoM.W. LiZ. MorrisC.G. MendenhallN.P. Can proton therapy improve the therapeutic ratio in breast cancer patients at risk for nodal disease?Am. J. Clin. Oncol.201437656857410.1097/COC.0b013e318280d614 23466577
     [Google Scholar]
  24. MehrotraR. YadavK. Breast cancer in India: Present scenario and the challenges ahead.World J. Clin. Oncol.202213320921810.5306/wjco.v13.i3.209 35433294
     [Google Scholar]
  25. MooT.A. SanfordR. DangC. MorrowM. Overview of breast cancer therapy.PET Clin.201813333935410.1016/j.cpet.2018.02.006 30100074
     [Google Scholar]
  26. RutenbergM.S. FlampouriS. HoppeB.S. Proton therapy for Hodgkin lymphoma.Curr. Hematol. Malig. Rep.20149320321110.1007/s11899‑014‑0212‑7 24842407
     [Google Scholar]
  27. RosenbergS.A. KaplanH.S. The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984.Int. J. Radiat. Oncol. Biol. Phys.198511152210.1016/0360‑3016(85)90357‑8 3881376
     [Google Scholar]
  28. EngertA. HaverkampH. KobeC. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin’s lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.Lancet201237998281791179910.1016/S0140‑6736(11)61940‑5 22480758
     [Google Scholar]
  29. HoltzmanA. FlampouriS. LiZ. MendenhallN.P. HoppeB.S. Proton therapy in a pediatric patient with stage III Hodgkin lymphoma.Acta Oncol.201352359259410.3109/0284186X.2013.765966 23477362
     [Google Scholar]
  30. HodgsonD.C. GilbertE.S. DoresG.M. Long-term solid cancer risk among 5-year survivors of Hodgkin’s lymphoma.J. Clin. Oncol.200725121489149710.1200/JCO.2006.09.0936 17372278
     [Google Scholar]
  31. JemalA. SiegelR. WardE. Cancer Statistics, 2008.CA Cancer J. Clin.2008582719610.3322/CA.2007.0010 18287387
     [Google Scholar]
  32. OnoT. WadaH. IshikawaH. TamamuraH. TokumaruS. Clinical results of proton beam therapy for esophageal cancer: Multicenter retrospective study in Japan.Cancers201911799310.3390/cancers11070993 31315281
     [Google Scholar]
  33. MukherjeeS. GiriS. Cytosponge: A breakthrough in detection of barrett’s esophagus. CANCER THERAPY.USAMedDocs Publishers201917
     [Google Scholar]
  34. VyfhuisM.A.L. OnyeukuN. DiwanjiT. Advances in proton therapy in lung cancer.Ther. Adv. Respir. Dis.20181210.1177/1753466618783878 30014783
     [Google Scholar]
  35. GillinM.T. SahooN. BuesM. Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas M.D. Anderson cancer center, proton therapy center, Houston.Med. Phys.201037115416310.1118/1.3259742 20175477
     [Google Scholar]
/content/journals/cctr/10.2174/0115733947304796240520043832
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Proton Therapy: A Ray of Hope for the Cancer Patients
Curr Cancer Ther Rev 21, 905 (2025); https://doi.org/10.2174/0115733947304796240520043832
/content/journals/cctr/10.2174/0115733947304796240520043832
/content/journals/cctr/10.2174/0115733947304796240520043832
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  • Article Type:     Review Article
Keyword(s): Cancer; disease; pencil beam; proton therapy; radiation therapy; velocity

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