Adolescent Psychiatry - Online First
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Individual Difference Variables in Adolescent Psychopathology: A Reflection on Cultural Norms, Intervention, and Attribution of Meaning: An Australian Case Study
By Anne BeckerAvailable online: 16 July 2025More LessAdolescents from non-dominant social and cultural backgrounds frequently experience additional compounding factors that impact mental health and social-emotional wellbeing, occasionally necessitating psychiatric intervention. Further, young people from refugee backgrounds face suicide risk factors in addition to those experienced by their peers. At present, culturally transferable, evidence-based interventions for adolescents residing in multicultural populations are not readily available, despite extensive research that demonstrates the positive effects of these interventions. This article aimed to (1) justify the importance of awareness training for mental health professionals working with multicultural adolescent populations, (2) discuss the implications for advancing preventative programs to minimise universal responses to assessment and intervention of adolescents from non-dominant cultures, and (3) examine existing interventions. Six brief case studies in the form of a vignette are presented to highlight some of the challenges that adolescents from different cultural backgrounds face in the Australian context.
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Prediction of Antithrombin Activity and Bioavailability of a Synthetic Peptide Using a Decision Tree Algorithm
Available online: 16 June 2025More LessBackgroundThrombosis is a major cause of mortality from cardiovascular disease (CVD). The use of known antithrombin drugs is limited by the presence of side effects and complications. Peptides may be promising antithrombin agents.
ObjectiveA peptide having the amino acid sequence QLSNGLFLFVDYLWW, designated as QW-13, was designed, synthesized, and used as a research object to evaluate the efficiency of the algorithm.
MethodsThe solid-phase Fmoc (SPPS) method, followed by purification by high-performance liquid chromatography (HPLC) was used for synthesis. The molecular weight distribution of the peptide was estimated by mass spectrometry. Peptide identification was performed using the MALDI-TOF MS Ultraflex method. Mass spectra were analyzed using the Mascot program. To confirm the efficiency of the algorithm, the antithrombin effect of the peptide was studied, which was evaluated by the activated partial thromboplastin time (APTT) of human citrate blood plasma coagulation.
ResultsA decision tree algorithm was developed to predict antithrombin activity and bioavailability of oral peptides. The top-down inductions of decision tree algorithms were used to create the algorithm. The decision tree is pruned if there is a mismatch in the peptide under study. Algorithm criteria or descriptors include amino acid sequence, number of amino acids, molecular weight, clinical potency, body distribution and metabolism index, plasma clearance, and half-life. According to the algorithm, if the result of “Antithrombin Peptide” is positive, it is concluded that it is bioavailable and effective for clinical use. To validate and evaluate the efficiency of the algorithm, a peptide containing antithrombin amino acid sequences was synthesized. The algorithm found the peptide to be antithrombin and bioavailable. The results of the biological activity of the peptide were confirmed in an in vitro experiment.
ConclusionEmploying a decision tree method to assess the antithrombin activity and bioavailability of peptides can facilitate the development of effective oral peptides, hence minimizing the development time and the quantity of in vitro and in vivo studies required to validate efficacy.
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Rates of Trauma Exposure, Posttraumatic Stress Disorder (PTSD), Depression, and Anxiety Symptoms in Primary School Children: Findings from Six Months Before the COVID-19 Pandemic
Authors: Siti Raudzah Ghazali, Chen Yoke Yong, Ask Elklit, Amanda Albert, Sana Rehman and Ang Ai LingAvailable online: 16 June 2025More LessIntroductionStudies on mental health rates among primary school children are still limited, particularly related to psychological trauma and its relationship to other mental health challenges. The objective of this study was to (1) examine the prevalence of PTSD, depression, and anxiety symptoms in primary school children before the Covid-19 pandemic; (2) identify the relationship between PTSD, depression and anxiety symptoms; and (3) investigate potential gender differences in PTSD symptoms.
MethodsThis is the first cross-sectional study examining the rates of trauma exposure, posttraumatic stress disorder (PTSD), depression, and anxiety symptoms in primary school children before the covid-19 pandemic in Malaysia. Two hundred and twenty-one students participated in this study. They were recruited from four primary schools that volunteered to participate in this study. PTSD Checklist for DSM-5 (PCL-5), Child PTSD Symptoms Scale-5 (CPSS-5), The Center for Epidemiologic Studies Depression Scale version (CESD), and the Spence Children's Anxiety Scale (SCAS) were used to survey psychological symptoms.
ResultsMost of the students, or 54.3% of them, have experienced at least one traumatic event. Of 221 students, 39.4% reported having PTSD symptoms, 38% reported having depressive symptoms, and 19% reported having anxiety symptoms. Female students were more likely to report PTSD symptoms compared to male students. The first regression analysis model indicated that depressive symptoms were the only significant predictors of PTSD. In the second model, religion, family income, anxiety, and PTSD symptoms were significant predictors of depressive symptoms. In the third model, depressive symptoms were the sole significant predictors of anxiety.
DiscussionThis pre-pandemic timeframe study offers crucial baseline information for understanding mental health conditions and ensures accurate assessment of how the pandemic may have influenced rates of anxiety, depression, and PTSD.
ConclusionThe study reveals that primary school children experience high levels of trauma, PTSD, depression, and anxiety, especially before the COVID-19 pandemic. During the early phases of the pandemic, these mental health issues have been largely neglected in Malaysia, with limited preventative and therapeutic interventions available. Future research should focus on documenting the prevalence of these issues in relation to the COVID-19 pandemic.
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The Association between Game Addiction and Feelings of Loneliness and Depression in Adolescents
Available online: 15 May 2025More LessIntroductionAdolescence is a critical period during which loneliness can have profound negative effects, often leading individuals to turn to modern media such as video games and social networks. As these media increasingly replace face-to-face interactions, concerns arise about their potential to exacerbate loneliness and contribute to depression. This study aimed to explore the relationship between loneliness, depression, and game addiction in adolescents.
MethodsThis cross-sectional analytical study was conducted on 327 students aged 15 to 19, selected through multi-stage cluster sampling. Data were collected using demographic questionnaires, the UCLA Loneliness Scale, Depression Anxiety Stress Scales (DASS-21), and the Game Addiction Scale. Statistical analysis was performed using SPSS and AMOS software.
ResultsThe average loneliness score among students was moderate (47.2 ± 9.6). Depression, anxiety, and stress levels were generally low; however, 17.7% of students exhibited game addiction, 29.26% experienced severe or very severe depression, 31.37% had severe or very severe anxiety, and 76.13% reported severe stress. A significant correlation was observed between loneliness, depression, anxiety, stress, and game addiction (P < 0.001). Loneliness, as an exogenous variable, was found to influence depression both directly and indirectly through game addiction.
DiscussionGame addiction is higher in boys and linked to loneliness, depression, and anxiety. Family and educational environments play key preventive roles. Cultural and methodological differences affect study results.
ConclusionGame addiction is an emerging concern, particularly among adolescents. School officials and educators must address this phenomenon seriously to mitigate its negative psychological impacts and promote healthy development.
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The Relationship Between BPD, Thwarted Belongingness, Perceived Burdensomeness, and Suicidality in an Adolescent DBT Partial Hospital Program
Available online: 06 March 2025More LessBackgroundPeople diagnosed with Borderline Personality Disorder (BPD) often endorse suicidality. One of the leading theories on the causes of suicidality, the interpersonal-psychological theory of suicide (IPTS), argues that this suicidal desire is driven by perceived burdensomeness (PB), the belief that others are better off without the individual, and thwarted belongingness (TB), the unmet need for social connection. Given that a distinguishing characteristic of BPD is the prevalence of interpersonal difficulties and negative cognitions, the IPTS is an important framework to use when looking at the link between BPD and suicidality. The relationship between BPD, PB, TB, and suicidality has been researched in the past, but this relationship within the context of a dialectical behavior therapy (DBT) partial hospital program (PHP) has yet to be analyzed.
ObjectiveThis study examined the relationship between these measures in a DBT PHP for adolescents/young adults.
MethodOne hundred seventy-six adolescents/young adults in a comprehensive DBT PHP completed surveys measuring suicidality, TB, PB, and BPD symptoms upon intake and discharge.
ResultsAnalyses found that all outcome measures significantly improved from admission to discharge and that most variables were positively correlated. Results also showed that PB and depression scores emerged as unique predictors of suicidality at discharge.
ConclusionAn adherent DBT PHP can be an effective treatment option for adolescents/young adults endorsing BPD symptoms, TB, PB, and suicidality. Future studies should examine the specific aspects of DBT that are most important in decreasing these symptoms.
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The Moderated Mediation Relationship Between Trait Impulsivity, Emotional Regulation, ADHD Hyperactivity/Impulsivity, and Oppositional Defiant Disorder Symptoms in Emerging Adults
Authors: Rapson Gomez, Taylor Brown and Shaun WatsonAvailable online: 04 February 2025More LessIntroduction/ObjectiveThe present study explored a moderated mediation model within a cohort of emerging adults, examining the interplay between Trait Impulsivity (TI), Emotional Regulation (ER), and symptoms of ADHD Hyperactivity/Impulsivity (HI) and Oppositional Defiant Disorder (ODD).
MethodsUtilizing a convenience sample of 210 emerging adults (men = 49, women = 161; mean age 21.17 years; SD = 2.20 years), the study employed standardized measures to analyze the relationships between TI, HI, ODD, and ER, using Hayes’s macro for SPSS Process model 14.
ResultsThe findings showed that HI mediated the association between TI and ODD and that ER moderated the association between HI and ODD, such that lower levels of ER increased the association.
ConclusionsThese findings align with the Trait Impulsivity Hypothesis (TIH), extending its application by integrating temperament literature on ADHD. This study contributes to the theoretical and practical understanding of impulsivity's role in externalizing disorders, highlighting the importance of ER in this dynamic.
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The Role of Social Media in Shaping Adolescent Mental Well-being: A Comprehensive Review on Its Pros and Cons
Available online: 15 January 2025More LessObjectiveThe objective of this review is to explore the impact of social media use on the mental health of teenagers, considering both advantages and disadvantages through a Narrative evaluation of recent studies.
MethodsA Narrative review of current literature was conducted to assess the effects of social media on adolescent mental health. The findings were categorized into seven areas: general mental health effects, specific issues such as anxiety and depression, behavioral impacts like addiction and self-regulation, effects on vulnerable populations, the influence of COVID-19, digital mental health services, ethical considerations with AI, and implications for academic achievement and public health.
ResultsSocial media use has both positive and negative effects on adolescent mental health. It is associated with an increase in behavioral issues such as addiction and mental health problems like anxiety and depression. Vulnerable groups, including LGBTQ+ youth and victims of cyberbullying, face heightened risks. The COVID-19 pandemic exacerbated these mental health challenges, though social media provided essential support networks. Digital mental health services were beneficial but raised ethical concerns, particularly regarding privacy and the need for culturally sensitive interventions.
ConclusionThe review underscores the need for balanced strategies to mitigate the negative impacts of social media on adolescent mental health. Comprehensive digital literacy programs, culturally relevant interventions, and ethical considerations in digital mental health services are crucial to supporting adolescent well-being in the digital age.
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Digital Screen Time and Associated Health Factors: A Bibliometric Study on Global Research Trends Between 2012-2023
Authors: Arti Singh, P Padma Sri Lekha, Bhoomika N Jadhav and E.P. Abdul AzeezAvailable online: 14 January 2025More LessBackgroundScreen time has become an inevitable aspect of daily life due to increased technological access and changes in the social and economic landscapes. The increase in screen time is associated with the development of various health conditions. Contextually, research on screen time and its health impact has been studied widely. Therefore, the present study tried to understand the trends and themes in the global research on screen time and its associated health aspects.
MethodWe adopted a bibliometric review, and the data were extracted from the SCOPUS database, limiting it to 2012-2023 (n =4077). The final number of studies considered for the analysis was 2919 after applying the inclusion and exclusion criteria.
ResultsScientific production has increased over the years on this topic, with few consistent contributors (Tremblay MS, Chaput JP, and Carson V) and sources from Western countries leading the production in this domain. In addition, from the results of thematic network mapping, we identified the basic yet underdeveloped topics in screen time and health research, namely obesity, risk factors to health, and mental health. A good proportion of the studies involve children and adolescents as participants, indicating the growing trend of studying screen time risk factors for these age groups' health.
ConclusionIt was evident from the result that the earlier works have focused on screen time as a risk to health and well-being. However, its role in specific health conditions is underdeveloped. Further, the case of adolescents and children being a widely studied age group suggests the implications for their health and mental health.
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A Narrative Review on Aggression in Children and Adolescents: Anthropology, Developmental Phenomenology, Transdiagnostic Trajectories, Contextual Nosology, and Strategic Pathways for Interventions
Authors: Mayank Gupta and Nihit GuptaAvailable online: 02 January 2025More LessIntroduction/ObjectiveThe transdiagnostic construct of aggression in children and adolescents is often characterized by distinct mental phenomena, such as irritability, emotional dysregulation (ED), anger, and outbursts. However, these terms are frequently interchanged in clinical settings despite their distinct semantic nuances. Therefore, it is critical to delve into the complex dynamics of aggression, irritability, and emotional dysregulation in the child and adolescent population.
MethodsAn extensive search was conducted across diverse databases using the keywords “Aggression,” “Violence,” “Irritability,” and “Emotional dysregulation.” This search encompassed articles on childhood aggression, covering its prevalence, risk factors, clinical manifestations, assessment methods, treatment modalities, and prognostic indicators. Initial screening identified 261 articles, with 40 selected for the initial draft and an additional 15 included later, either manually or via reverse citations.
ResultsThe appraisal of aggression is challenging due to its terminology and diagnostic complexities, especially in distinguishing normative behavior from psychopathological impairments. There is a significant lack of empirical evidence, like systematic reviews concerning the heterogenous dimensional understanding of aggression, including its social determinants, comorbidities, and targeted interventions. Likewise, there is a crucial need to assess comorbid conditions like ADHD, DMDD, and ODD to gain deeper insights into their developmental, social, and biological determinants. Emphasizing comorbidity assessment and age of onset during initial diagnostic evaluations is vital, followed by a structured approach to interventions encompassing behavioral and pharmacological strategies.
ConclusionThere is a need for a stepwise multidimensional assessment towards contextual understanding of aggression and sequencing the treatment of aggression in children and adolescents. It is paramount to incorporate tailored interventions with shared decision-making.
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