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2000
Volume 20, Issue 1
  • ISSN: 2667-3878
  • E-ISSN: 2667-3886

Abstract

Introduction

The objective of the present study was the development and evaluation of Norfloxacin lipid microspheres as topical gels for adjunct therapy to overcome complex clinical challenges presented by moist, thermally coagulated burn wounds.

Methods

Norfloxacin-loaded lipid microspheres were prepared using the melt diffusion technique with Compritol ATO HD5, stearic acid, Tween 20, Span 80, and Transcutol P and incorporated into topical gels formulated with Carbopol 971P NF.

Results

The lipid microspheres exhibited an average size of 65.22+23.39 μm and drug entrapment efficiency of 81.58 ± 0.81%. The scanning electron microscopy confirmed spherical particle morphology, while differential scanning calorimetry indicated the amorphous nature of norfloxacin within the microspheres. studies demonstrated an extended release of norfloxacin, with 72.33 ± 1.46% released from microspheres and 63.18 ± 1.24% from topical gels after 8 hours. studies revealed 28.16 ± 0.63% of norfloxacin permeating through second-degree burnt porcine skin and 21.12 ± 1.38% through intact porcine skin after 8 hours from topical gels. antibacterial studies indicated a lower MIC for the lipid microspheres compared to the pure drug.

Discussion

The melt diffusion technique yielded micron-sized spherical particles with a drug entrapment efficiency exceeding 80%. and studies confirmed the extended release and enhanced permeation of norfloxacin. Furthermore, antibacterial evaluations demonstrated increased effectiveness of the microspheres, attributed to improved solubility and sustained drug release.

Conclusions

The approach shows promise in enhancing Norfloxacin availability for managing burn wound complexities. However, preclinical, clinical, and regulatory evaluations are required to establish the utility of the proposed approach. Further investigations into its application for other types of chronic or infected wounds could broaden its therapeutic potential.

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Lipid Microspheres for Topical Delivery of Norfloxacin: Development and Evaluation
Recent Advances in Drug Delivery and Formulation 20, 66 (2026); https://doi.org/10.2174/0126673878348440250422045340
/content/journals/raddf/10.2174/0126673878348440250422045340
/content/journals/raddf/10.2174/0126673878348440250422045340
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  • Article Type:     Research Article
Keyword(s): broth dilution; burnt porcine skin; extended release; lipid microspheres; Norfloxacin; topical delivery

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