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2000
Volume 15, Issue 7
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Southern Asia boasts a diverse array of species, renowned for their antimicrobial, antioxidant, and anti-inflammatory properties. These plants, also native to the American tropics, have played a significant role in traditional medicine and culinary practices. Notably, L., L., and L. are recognized for their bioactive compounds, particularly alkaloids, which contribute to their beneficial properties. In recent decades, there has been increased focus on studying these plants for their potential anticancer effects, encompassing both direct cytotoxic effects and indirect modulation of the tumor microenvironment. Major scientific literature databases were consulted using appropriate keywords to present a comprehensive and proportionate analysis of the anticancer potential of the three species, including valuable insights into their therapeutic perspectives, molecular mechanisms, and broader applications in cancer treatment. Numerous pharmacological trials on the bioactive components and extracts have underscored their clinical significance, revealing multifaceted actions such as antiproliferative effects, antiangiogenic properties, immunomodulation, antimetastatic activity, induction of apoptosis, and modulation of various signaling pathways in both malignant and non-malignant disorders. Among the explored compounds, piperine and piperlongumine, prominent alkaloids within the genus, have demonstrated notable efficacy in restricting the growth of cancer cells and tumors. This article emphasizes the biomedical and pharmacological findings related to the anticancer properties of the three species, with a focus on their mechanism of action. These insights could open avenues for future clinical scenarios and therapeutic utilization of bioactive substances and extracts derived from these species.

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2025-12-28

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/content/journals/npj/10.2174/0122103155337404240906071903
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Mechanistic Insight into Anticancer Prowess of Piper Species and their Bioactive Compounds: A Review
Natural Products Journal, The 15, E22103155337404 (2025); https://doi.org/10.2174/0122103155337404240906071903
/content/journals/npj/10.2174/0122103155337404240906071903
/content/journals/npj/10.2174/0122103155337404240906071903
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  • Article Type:     Review Article
Keyword(s): Anticancer; bioactive compounds; molecular mechanism; Piper species; piperine; piperlongumine

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