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2000
Volume 15, Issue 3
  • ISSN: 2210-6812
  • E-ISSN: 2210-6820

Abstract

Background

Gallic acid (GA) is an important biomarker with significant relevance in the food, pharmaceutical, and environmental industries, requiring highly sensitive and selective detection techniques.

Aim

This study presents the development of a robust electrochemical sensor for GA detection, utilizing a zinc oxide/graphene oxide (ZnO/GO) nanocomposite-modified electrode, with a focus on applications for assessing the impact of GA on oral health.

Methods

GO was synthesized a modified Hummers' method, while ZnO nanoparticles with rod-shaped morphology were prepared hydrothermally. The ZnO/GO composite film was prepared by combining their dispersions and thermal treatment.

Results

UV-visible spectra confirmed the interaction between ZnO and GO through redshift, and FTIR analysis revealed characteristic Zn-O and C-O bonds. Cyclic voltammetry (CV) demonstrated that the ZnO/GO-modified electrode detects GA at a remarkably low potential (0.1 V vs. Ag/AgCl) compared to previously reported GA sensors.

Conclusion

This new sensor exhibited a low detection limit of 31 μM and a wide linear response range from 50 – 300 µM with excellent sensitivity (slope = 0.0537 µA/µM, R2 = 0.9971). In the future, this sensor may find some application in the field of dentistry to monitor the efficacy of the GA for patients undergoing dental treatments like dentin hypersensitivity, proliferation of oral bacteria, oral ulcer, plaque, remineralization, and gingivitis.

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2025-03-21
2025-10-10

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Electrochemical Detection of Gallic Acid using Zinc Oxide/Graphene Oxide Hybrid Nanocomposite-modified Electrode
Nanoscience & Nanotechnology-Asia 15, E22106812375545 (2025); https://doi.org/10.2174/0122106812375545250313081034
/content/journals/nanoasi/10.2174/0122106812375545250313081034
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  • Article Type:     Research Article
Keyword(s): biomarker; electrochemical sensor; Gallic acid sensing; graphene oxide/zinc oxide; modified electrode; nanocomposite-modified

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